4G34.A | EIF2AK3

General Structure Information 4g34 EIF2AK3 crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution 2.7Å AUTH J.M.AXTEN,J.R.MEDINA,Y.FENG,A.SHU,S.P.ROMERIL,S.W.GRANT,AUTH 2 W.H.LI,D.A.HEERDING,E.MINTHORN,T.MENCKEN,C.ATKINS,Q.LIU,AUTH 3 S.RABINDRAN,R.KUMAR,X.HONG,A.GOETZ,T.STANLEY,J.D.TAYLOR,AUTH 4 S.D.SIGETHY,G.H.TOMBERLIN,A.M.HASSELL,K.M.KAHLER,AUTH 5 L.M.SHEWCHUK,R.T.GAMPETITL DISCOVERY OFTITL 2 7-METHYL-5-(1-{[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}-2,3-TITL 3 DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINETITL 4 (GSK2606414), A POTENT AND SELECTIVE FIRST-IN-CLASSTITL 5 INHIBITOR OF PROTEIN KINASE R (PKR)-LIKE ENDOPLASMICTITL 6 RETICULUM KINASE […]

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3KJD.A | PARP2

General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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3OTE.B | THG1L

General Structure Information 3ote THG1L crystal structure of human trnahis guanylyltransferase (thg1)- native i 2.56Å AUTH S.J.HYDE,B.E.ECKENROTH,B.A.SMITH,W.A.EBERLEY,N.H.HEINTZ,AUTH 2 J.E.JACKMAN,S.DOUBLIETITL TRNAHIS GUANYLYLTRANSFERASE (THG1), A UNIQUE 3-5TITL 2 NUCLEOTIDYL TRANSFERASE, SHARES UNEXPECTED STRUCTURALTITL 3 HOMOLOGY WITH CANONICAL 5-3 DNA POLYMERASES.REF PROC.NATL.ACAD.SCI.USA V. 107 20305 2010REFN ISSN 0027-8424PMID 21059936DOI 10.1073/PNAS.1010436107 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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3OP5.C | VRK1

General Structure Information 3op5 VRK1 human vaccinia-related kinase 1 2.4Å AUTH C.K.ALLERSTON,S.UTTARKAR,P.SAVITSKY,J.M.ELKINS,AUTH 2 P.FILIPPAKOPOULOS,T.KROJER,P.RELLOS,O.FEDOROV,J.ESWARAN,AUTH 3 B.BRENNER,T.KEATES,S.DAS,O.KING,R.CHALK,G.BERRIDGE,AUTH 4 F.VON DELFT,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 5 C.BOUNTRA,S.KNAPPTITL HUMAN VACCINIA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants

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2PQF.B | PARP12

General Structure Information 2pqf PARP12 human poly(adp-ribose) polymerase 12, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant […]

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3TUG.A | ITCH

General Structure Information 3tug ITCH crystal structure of the hect domain of itch e3 ubiquitin ligase 2.27Å AUTH E.DOBROVETSKY,A.DONG,S.XUE,C.BUTLER,A.WERNIMONT,J.R.WALKER,AUTH 2 W.TEMPEL,S.DHE-PAGANON,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 Y.TONGTITL CRYSTAL STRUCTURE OF THE HECT DOMAIN OF ITCH E3 UBIQUITINTITL 2 LIGASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4E36.A | ERAP2

General Structure Information 4e36 ERAP2 crystal structure of the human endoplasmic reticulum aminopeptidase 2 variant n392k 3.22Å AUTH I.EVNOUCHIDOU,J.BIRTLEY,S.SEREGIN,A.PAPAKYRIAKOU,E.ZERVOUDI,AUTH 2 M.SAMIOTAKI,G.PANAYOTOU,P.GIASTAS,O.PETRAKIS,D.GEORGIADIS,AUTH 3 A.AMALFITANO,E.SARIDAKIS,I.M.MAVRIDIS,E.STRATIKOSTITL A COMMON SINGLE NUCLEOTIDE POLYMORPHISM IN ENDOPLASMICTITL 2 RETICULUM AMINOPEPTIDASE 2 INDUCES A SPECIFICITY SWITCH THATTITL 3 LEADS TO ALTERED ANTIGEN PROCESSING.REF J.IMMUNOL. V. 189 2383 2012REFN ISSN 0022-1767PMID 22837489DOI 10.4049/JIMMUNOL.1200918 Variant […]

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2HDH.B | HADH

General Structure Information 2hdh HADH biochemical characterization and structure determination of human heart short chain l-3-hydroxyacyl coa dehydrogenase provide insight into catalytic mechanism 2.2Å AUTH J.J.BARYCKI,L.K.OBRIEN,J.M.BRATT,R.ZHANG,R.SANISHVILI,AUTH 2 A.W.STRAUSS,L.J.BANASZAKTITL BIOCHEMICAL CHARACTERIZATION AND CRYSTAL STRUCTURETITL 2 DETERMINATION OF HUMAN HEART SHORT CHAIN L-3-HYDROXYACYL-COATITL 3 DEHYDROGENASE PROVIDE INSIGHTS INTO CATALYTIC MECHANISM.REF BIOCHEMISTRY V. 38 5786 1999REFN ISSN 0006-2960PMID […]

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1M3G.A | DUSP2

General Structure Information 1m3g DUSP2 solution structure of the catalytic domain of mapk phosphatase pac-1: insights into substrate-induced enzymatic activation -1.0Å AUTH A.FAROOQ,O.PLOTNIKOVA,G.CHATURVEDI,S.YAN,L.ZENG,AUTH 2 Q.ZHANG,M.-M.ZHOUTITL SOLUTION STRUCTURE OF THE MAPK PHOSPHATASE PAC-1TITL 2 CATALYTIC DOMAIN INSIGHTS INTO SUBSTRATE-INDUCEDTITL 3 ENZYMATIC ACTIVATION OF MKPREF STRUCTURE V. 11 155 2003REFN ISSN 0969-2126PMID 12575935DOI 10.1016/S0969-2126(02)00943-7 Variant Set Distributions […]

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1N3L.A | YARS

General Structure Information 1n3l YARS crystal structure of a human aminoacyl-trna synthetase cytokine 1.18Å AUTH X.-L.YANG,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASETITL 2 CYTOKINEREF PROC.NATL.ACAD.SCI.USA V. 99 15369 2002REFN ISSN 0027-8424PMID 12427973DOI 10.1073/PNAS.242611799 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants

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