Assessment of Structural Intolerance and Durability
General Structure Information 2jc2 SRI the crystal structure of the natural f112l human sorcin mutant 2.5Å AUTH S.FRANCESCHINI,A.ILARI,D.VERZILI,C.ZAMPARELLI,AUTH 2 A.ANTARAMIAN,A.RUEDA,H.H.VALDIVIA,E.CHIANCONE,AUTH 3 G.COLOTTITITL MOLECULAR BASIS FOR THE IMPAIRED FUNCTION OF THETITL 2 NATURAL F112L SORCIN MUTANT: X-RAY CRYSTALTITL 3 STRUCTURE, CALCIUM AFFINITY, AND INTERACTION WITHTITL 4 ANNEXIN VII AND THE RYANODINE RECEPTOR.REF FASEB J. V. 22 […]
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3dpe MMP8 crystal structure of the complex between mmp-8 and a non- zinc chelating inhibitor 1.6Å AUTH G.POCHETTI,R.MONTANARI,C.GEGE,C.CHEVRIER,AUTH 2 A.G.TAVERAS,F.MAZZATITL EXTRA BINDING REGION INDUCED BY NON-ZINC CHELATINGTITL 2 INHIBITORS INTO THE S(1) SUBSITE OF MATRIXTITL 3 METALLOPROTEINASE 8 (MMP-8)REF J.MED.CHEM. V. 52 1040 2009REFN ISSN 0022-2623PMID 19173605DOI 10.1021/JM801166J Variant Set Distributions Ripley’s […]
General Structure Information 2k8o ITGAL solution structure of integrin alpha l -1.0Å AUTH A.BHUNIA,X.-Y.TANG,H.MOHANRAM,S.-M.TAN,AUTH 2 S.BHATTACHARJYATITL NMR SOLUTION CONFORMATIONS AND INTERACTIONS OFTITL 2 INTEGRIN {ALPHA}L{BETA}2 CYTOPLASMIC TAILSREF J.BIOL.CHEM. V. 284 3873 2009REFN ISSN 0021-9258PMID 19073598DOI 10.1074/JBC.M807236200 Variant Set Distributions Mapped Variants
General Structure Information 3ebm TPT1 crystal structure of human translationally controlled tumour associated protein (htctp) mutant e12v 2.6Å AUTH X.DONG,B.YANG,Y.LI,C.ZHONG,J.DINGTITL MOLECULAR BASIS OF THE ACCELERATION OF THE GDP-GTPTITL 2 EXCHANGE OF HUMAN RAS HOMOLOG ENRICHED IN BRAIN BYTITL 3 HUMAN TRANSLATIONALLY CONTROLLED TUMOR PROTEIN.REF J.BIOL.CHEM. V. 284 23754 2009REFN ISSN 0021-9258PMID 19570981DOI 10.1074/JBC.M109.012823 Variant Set […]
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1rk9 PVALB solution structure of human alpha-parvalbumin (minimized average structure) -1.0Å AUTH I.BAIG,I.BERTINI,C.DEL BIANCO,Y.K.GUPTA,Y.-M.LEE,AUTH 2 C.LUCHINAT,A.QUATTRONETITL PARAMAGNETISM-BASED REFINEMENT STRATEGY FOR THETITL 2 SOLUTION STRUCTURE OF HUMAN ALPHA-PARVALBUMINREF BIOCHEMISTRY V. 43 5562 2004REFN ISSN 0006-2960PMID 15122922DOI 10.1021/BI035879K Variant Set Distributions Mapped Variants
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants