Assessment of Structural Intolerance and Durability
General Structure Information 3ghg FGB crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ghg FGA crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c29 VWF crystal structure of high-affinity von willebrand factor a1 domain with disulfide mutation 2.2Å AUTH M.A.BLENNER,X.DONG,T.A.SPRINGERTITL TOWARDS THE STRUCTURAL BASIS OF REGULATION OF VONTITL 2 WILLEBRAND FACTOR BINDING TO GLYCOPROTEIN IBREF J.BIOL.CHEM. V. 289 5565 2014REFN ISSN 0021-9258PMID 24391089DOI 10.1074/JBC.M113.511220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jvq SERPINC1 crystal structure at 2.6a of the ternary complex between antithrombin, a p14-p8 reactive loop peptide, and an exogenous tetrapeptide 2.6Å AUTH A.ZHOU,P.E.STEIN,J.A.HUNTINGTON,P.SIVASOTHY,D.A.LOMAS,AUTH 2 R.W.CARRELLTITL HOW SMALL PEPTIDES BLOCK AND REVERSE SERPIN POLYMERISATIONREF J.MOL.BIOL. V. 342 931 2004REFN ISSN 0022-2836PMID 15342247DOI 10.1016/J.JMB.2004.07.078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2wpi F9 factor ixa superactive double mutant 1.99Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2anw KLKB1 expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: implications for structure-based design of protease inhibitors 1.85Å AUTH J.TANG,C.L.YU,S.R.WILLIAMS,E.SPRINGMAN,D.JEFFERY,AUTH 2 P.A.SPRENGELER,A.ESTEVEZ,J.SAMPANG,W.SHRADER,AUTH 3 J.SPENCER,W.YOUNG,M.MCGRATH,B.A.KATZTITL EXPRESSION, CRYSTALLIZATION, AND THREE-DIMENSIONALTITL 2 STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMATITL 3 KALLIKREIN.REF J.BIOL.CHEM. V. 280 41077 2005REFN ISSN 0021-9258PMID 16199530DOI […]
General Structure Information 1f9p PPBP crystal structure of connective tissue activating peptide- iii(ctap-iii) complexed with polyvinylsulfonic acid 1.93Å AUTH J.YANG,T.FAULK,R.ASTER,G.VISENTIN,B.EDWARDS,AUTH 2 C.CASTORTITL STRUCTURE OF THE CXC CHEMOKINE, CONNECTIVE TISSUETITL 2 ACTIVATING PEPTIDE-III, COMPLEXED WITH THE HEPARINTITL 3 ANALOGUE, POLYVINYLSULFONIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants