Assessment of Structural Intolerance and Durability
General Structure Information 3pmi MUM1 pwwp domain of human mutated melanoma-associated antigen 1 2.82Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants
General Structure Information 3e9l PRPF8 crystal structure of human prp8, residues 1755-2016 1.95Å AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hsa IL17A structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 1r79 DGKD solution structure of the c1 domain of the human diacylglycerol kinase delta -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C1 DOMAIN OF THE HUMANTITL 2 DIACYLGLYCEROL KINASE DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2rn9 COX17 solution structure of human apocox17 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,A.JANICKA,AUTH 2 M.MARTINELLI,H.KOZLOWSKI,P.PALUMAATITL A STRUCTURAL-DYNAMICAL CHARACTERIZATION OF HUMANTITL 2 COX17REF J.BIOL.CHEM. V. 283 7912 2008REFN ISSN 0021-9258PMID 18093982DOI 10.1074/JBC.M708016200 Variant Set Distributions Mapped Variants
General Structure Information 3dbr NAE1 structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8s e1 (appbp1- uba3arg190gln-nedd8ala72arg) 3.05Å AUTH J.SOUPHRON,M.B.WADDELL,A.PAYDAR,Z.TOKGOZ-GROMLEY,AUTH 2 M.F.ROUSSEL,B.A.SCHULMANTITL STRUCTURAL DISSECTION OF A GATING MECHANISMTITL 2 PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8STITL 3 E1.REF BIOCHEMISTRY V. 47 8961 2008REFN ISSN 0006-2960PMID 18652489DOI 10.1021/BI800604C Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2kle PKD2 isic refined solution structure of the calcium binding domain of the c-terminal cytosolic domain of polycystin-2 -1.0Å AUTH F.H.SCHUMANN,H.HOFFMEISTER,M.SCHMIDT,R.BADER,AUTH 2 E.BESL,R.WITZGALL,H.R.KALBITZERTITL NMR-ASSIGNMENTS OF A CYTOSOLIC DOMAIN OF THETITL 2 C-TERMINUS OF POLYCYSTIN-2REF BIOMOL.NMR ASSIGN. V. 3 141 2009REFN ISSN 1874-2718PMID 19636966DOI 10.1007/S12104-009-9160-X Variant Set Distributions Mapped Variants