Assessment of Structural Intolerance and Durability
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mpx FGD5 crystal structure of the dh and ph-1 domains of human fgd5 2.8Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4g2v FRMPD1 structure complex of lgn binding with frmpd1 2.4Å AUTH Z.PAN,Y.SHANG,M.JIA,L.ZHANG,C.XIA,M.ZHANG,W.WANG,W.WENTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 INTERACTION BETWEEN LGN AND FRMPD1REF J.MOL.BIOL. V. 425 1039 2013REFN ISSN 0022-2836PMID 23318951DOI 10.1016/J.JMB.2013.01.003 Variant Set Distributions Mapped Variants
General Structure Information 3u21 NFRKB crystal structure of a fragment of nuclear factor related to kappa-b- binding protein (residues 370-495) (nfrkb) from homo sapiens at 2.18 a resolution 2.18Å AUTH A.KUMAR,S.MOCKLINGHOFF,F.YUMOTO,L.JAROSZEWSKI,C.L.FARR,AUTH 2 A.GRZECHNIK,P.NGUYEN,C.X.WEICHENBERGER,H.J.CHIU,H.E.KLOCK,AUTH 3 M.A.ELSLIGER,A.M.DEACON,A.GODZIK,S.A.LESLEY,B.R.CONKLIN,AUTH 4 R.J.FLETTERICK,I.A.WILSONTITL STRUCTURE OF A NOVEL WINGED-HELIX LIKE DOMAIN FROM HUMANTITL 2 NFRKB PROTEIN.REF PLOS ONE V. 7 43761 2012REFN […]
General Structure Information 3i8e DDB1 crystal structure of ddb1 in complex with the h-box motif of wdr42a 3.4Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRAL HIJACKERSTITL 2 AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1 UBIQUITIN LIGASETITL 3 MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4a4i LIN28B crystal structure of the human lin28b cold shock domain 1.95Å AUTH F.MAYR,A.SCHUTZ,N.DOGE,U.HEINEMANNTITL THE LIN28 COLD-SHOCK DOMAIN REMODELS PRE-LET-7 MICRORNA.REF NUCLEIC ACIDS RES. V. 40 7492 2012REFN ISSN 0305-1048PMID 22570413DOI 10.1093/NAR/GKS355 Variant Set Distributions Mapped Variants
General Structure Information 2d8s MARCH8 solution structure of the ring domain of the human cellular modulator of immune recognition protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 CELLULAR MODULATOR OF IMMUNE RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4dou ADIPOQ crystal structure of a single-chain trimer of human adiponectin globular domain 2.0Å AUTH X.MIN,B.LEMON,J.TANG,Q.LIU,R.ZHANG,N.WALKER,Y.LI,Z.WANGTITL CRYSTAL STRUCTURE OF A SINGLE-CHAIN TRIMER OF HUMANTITL 2 ADIPONECTIN GLOBULAR DOMAIN.REF FEBS LETT. V. 586 912 2012REFN ISSN 0014-5793PMID 22449980DOI 10.1016/J.FEBSLET.2012.02.024 Variant Set Distributions Mapped Variants
General Structure Information 2edv FRMPD1 solution structure of the pdz domain from human ferm and pdz domain containing 1 -1.0Å AUTH K.SEIMIYA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 FERM AND PDZ DOMAIN CONTAINING 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants