Assessment of Structural Intolerance and Durability
General Structure Information 3gdq HSPA1L crystal structure of the human 70kda heat shock protein 1-like atpase domain in complex with adp and inorganic phosphate 1.8Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,T.KOTENYOVA,AUTH 2 M.MOCHE,H.SCHULERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOUR HUMAN HSP70TITL 2 ISOFORMS: HSPA1L/HSP70-HOM, HSPA2/HSP70-2, HSPA6/HSP70B,TITL 3 AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN 1932-6203PMID […]
General Structure Information 2jxc EPS15 structure of the eps15-eh2 stonin2 complex -1.0Å AUTH J.RUMPF,B.SIMON,N.JUNG,T.MARITZEN,V.HAUCKE,M.SATTLER,AUTH 2 Y.GROEMPINGTITL STRUCTURE OF THE EPS15-STONIN2 COMPLEX PROVIDES A MOLECULARTITL 2 EXPLANATION FOR EH-DOMAIN LIGAND SPECIFICITY.REF EMBO J. V. 27 558 2008REFN ISSN 0261-4189PMID 18200045DOI 10.1038/SJ.EMBOJ.7601980 Variant Set Distributions Mapped Variants
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cp5 CLIP1 solution structure of the 1st cap-gly domain in human clip- 170/restin -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-170/RESTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2adc PTBP1 solution structure of polypyrimidine tract binding protein rbd34 complexed with cucucu rna -1.0Å AUTH F.C.OBERSTRASS,S.D.AUWETER,M.ERAT,Y.HARGOUS,AUTH 2 A.HENNING,P.WENTER,L.REYMOND,B.AMIR-AHMADY,AUTH 3 S.PITSCH,D.L.BLACK,F.H.T.ALLAINTITL STRUCTURE OF PTB BOUND TO RNA: SPECIFIC BINDINGTITL 2 AND IMPLICATIONS FOR SPLICING REGULATIONREF SCIENCE V. 309 2054 2005REFN ISSN 0036-8075PMID 16179478DOI 10.1126/SCIENCE.1114066 Variant Set Distributions Mapped Variants
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 3fe4 CA6 crystal structure of human carbonic anhydrase vi 1.9Å AUTH E.S.PILKA,G.KOCHAN,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF THE SECRETORY ISOZYME OF MAMMALIANTITL 2 CARBONIC ANHYDRASES CA VI: IMPLICATIONS FOR BIOLOGICALTITL 3 ASSEMBLY AND INHIBITOR DEVELOPMENTREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 419 485 2012REFN ISSN 0006-291XPMID 22366092DOI 10.1016/J.BBRC.2012.02.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1he3 BLVRB human biliverdin ix beta reductase: nadp/mesobiliverdin iv alpha ternary complex 1.4Å AUTH P.J.B.PEREIRA,S.MACEDO-RIBEIRO,A.PARRAGA,AUTH 2 R.PEREZ-LUQUE,O.CUNNINGHAM,K.DARCY,T.J.MANTLE,AUTH 3 M.COLLTITL STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE,TITL 2 AN EARLY FETAL BILIRUBIN IX PRODUCING ENZYMEREF NAT.STRUCT.BIOL. V. 8 215 2001REFN ISSN 1072-8368PMID 11224564DOI 10.1038/84948 Variant Set Distributions Mapped Variants