Assessment of Structural Intolerance and Durability
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 4a11 ERCC8 structure of the hsddb1-hscsa complex 3.31Å AUTH E.S.FISCHER,A.SCRIMA,K.BOHM,S.MATSUMOTO,G.M.LINGARAJU,AUTH 2 M.FATY,T.YASUDA,S.CAVADINI,M.WAKASUGI,F.HANAOKA,S.IWAI,AUTH 3 H.GUT,K.SUGASAWA,N.H.THOMATITL THE MOLECULAR BASIS OF CRL4(DDB2/CSA) UBIQUITIN LIGASETITL 2 ARCHITECTURE, TARGETING, AND ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 147 1024 2011REFN ISSN 0092-8674PMID 22118460DOI 10.1016/J.CELL.2011.10.035 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yhv PAK1 crystal structure of pak1 kinase domain with two point mutations (k299r, t423e) 1.8Å AUTH M.LEI,M.A.ROBINSON,S.C.HARRISONTITL THE ACTIVE CONFORMATION OF THE PAK1 KINASE DOMAINREF STRUCTURE V. 13 769 2005REFN ISSN 0969-2126PMID 15893667DOI 10.1016/J.STR.2005.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k8a PTK2 fragment-based discovery of focal adhesion kinase inhibitors 2.91Å AUTH U.GRADLER,J.BOMKE,D.MUSIL,V.DRESING,M.LEHMANN,G.HOLZEMANN,AUTH 2 H.GREINER,C.ESDAR,M.KRIER,T.HEINRICHTITL FRAGMENT-BASED DISCOVERY OF FOCAL ADHESION KINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 5401 2013REFN ISSN 0960-894XPMID 23973211DOI 10.1016/J.BMCL.2013.07.050 Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lg1 AKAP13 solution structure of the human akap13 ph domain and stabilizing dh helix -1.0Å AUTH M.LENOIR,M.SUGAWARA,J.KAUR,L.J.BALL,M.OVERDUINTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF THE RHOA GTPASETITL 2 BY THE LBC ONCOPROTEIN.REF J.BIOL.CHEM. V. 3 215 2014REFN ISSN 0021-9258PMID 24993829DOI 10.1074/JBC.M114.561787 Variant Set Distributions Mapped Variants
General Structure Information 3w9y DLG1 crystal structure of the human dlg1 guanylate kinase domain 2.2Å AUTH S.MORI,Y.TEZUKA,A.ARAKAWA,N.HANDA,M.SHIROUZU,T.AKIYAMA,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GUANYLATE KINASE DOMAIN FROM DISCSTITL 2 LARGE HOMOLOG 1 (DLG1/SAP97)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 435 334 2013REFN ISSN 0006-291XPMID 23624197DOI 10.1016/J.BBRC.2013.04.056 Variant Set Distributions Mapped Variants
General Structure Information 4d8o ANK2 crystal structure of the ankyrin-b zu5-zu5-upa-dd tandem 2.2Å AUTH C.WANG,C.YU,F.YE,Z.WEI,M.ZHANGTITL STRUCTURE OF THE ZU5-ZU5-UPA-DD TANDEM OF ANKYRIN-B REVEALSTITL 2 INTERACTION SURFACES NECESSARY FOR ANKYRIN FUNCTIONREF PROC.NATL.ACAD.SCI.USA V. 109 4822 2012REFN ISSN 0027-8424PMID 22411828DOI 10.1073/PNAS.1200613109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants