Assessment of Structural Intolerance and Durability
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 4nsc MICU1 crystal structure of cbara1 in the apo-form 3.2Å AUTH L.WANG,X.YANG,S.LI,Z.WANG,Y.LIU,J.FENG,Y.ZHU,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO MICU1 REGULATION OFTITL 2 MITOCHONDRIAL CALCIUM UPTAKE.REF EMBO J. V. 33 594 2014REFN ISSN 0261-4189PMID 24514027DOI 10.1002/EMBJ.201386523 Variant Set Distributions Mapped Variants
General Structure Information 3nw0 NDNL2 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Mapped Variants
General Structure Information 2le9 S100A13 ragec2-s100a13 tetrameric complex -1.0Å AUTH S.G.RANI,S.K.MOHAN,C.YUTITL INTERACTION OF S100A13 WITH RECEPTOR FOR ADVANCED GLYCATIONTITL 2 END PRODUCTS (RAGE) C2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3c5r BARD1 crystal structure of the bard1 ankyrin repeat domain and its functional consequences 2.0Å AUTH D.FOX,I.LE TRONG,P.RAJAGOPAL,P.S.BRZOVIC,R.E.STENKAMP,AUTH 2 R.E.KLEVITTITL CRYSTAL STRUCTURE OF THE BARD1 ANKYRIN REPEAT DOMAIN AND ITSTITL 2 FUNCTIONAL CONSEQUENCES.REF J.BIOL.CHEM. V. 283 21179 2008REFN ISSN 0021-9258PMID 18480049DOI 10.1074/JBC.M802333200 Variant Set Distributions Mapped Variants
General Structure Information 4gqb WDR77 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yud YTHDC1 solution structure of the yth domain in yth domain- containing protein 1 (putative splicing factor yt521) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE YTH DOMAIN IN YTHTITL 2 DOMAIN-CONTAINING PROTEIN 1 (PUTATIVE SPLICINGTITL 3 FACTOR YT521)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2km6 NLRP7 nmr structure of the nlrp7 pyrin domain -1.0Å AUTH A.S.PINHEIRO,M.PROELL,C.EIBL,R.PAGE,R.SCHWARZENBACHER,W.PETITITL THREE-DIMENSIONAL STRUCTURE OF THE NLRP7 PYRIN DOMAIN:TITL 2 INSIGHT INTO PYRIN-PYRIN-MEDIATED EFFECTOR DOMAIN SIGNALINGTITL 3 IN INNATE IMMUNITY.REF J.BIOL.CHEM. V. 285 27402 2010REFN ISSN 0021-9258PMID 20547486DOI 10.1074/JBC.M110.113191 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]