Assessment of Structural Intolerance and Durability
General Structure Information 1mkj KIF5B human kinesin motor domain with docked neck linker 2.7Å AUTH C.V.SINDELAR,M.J.BUDNY,S.RICE,N.NABER,R.FLETTERICK,AUTH 2 R.COOKETITL TWO CONFORMATIONS IN THE HUMAN KINESIN POWERTITL 2 STROKE DEFINED BY X-RAY CRYSTALLOGRAPHY AND EPRTITL 3 SPECTROSCOPY.REF NAT.STRUCT.BIOL. V. 9 844 2002REFN ISSN 1072-8368PMID 12368902 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1oe9 MYL6B crystal structure of myosin v motor with essential light chain – nucleotide-free 2.05Å AUTH P.-D.COUREUX,A.L.WELLS,J.MENETREY,C.M.YENGO,AUTH 2 C.A.MORRIS,H.L.SWEENEY,A.HOUDUSSETITL A STRUCTURAL STATE OF THE MYOSIN V MOTOR WITHOUTTITL 2 BOUND NUCLEOTIDEREF NATURE V. 425 419 2003REFN ISSN 0028-0836PMID 14508494DOI 10.1038/NATURE01927 Variant Set Distributions Mapped Variants
General Structure Information 3nmq HSP90AB1 hsp90b n-terminal domain in complex with ec44, a pyrrolo-pyrimidine methoxypyridine inhibitor 2.2Å AUTH T.J.YUN,E.K.HARNING,K.GIZA,D.RABAH,P.LI,J.W.ARNDT,AUTH 2 D.LUCHETTI,M.A.BIAMONTE,J.SHI,K.LUNDGREN,A.MANNING,M.R.KEHRYTITL EC144, A SYNTHETIC INHIBITOR OF HEAT SHOCK PROTEIN 90,TITL 2 BLOCKS INNATE AND ADAPTIVE IMMUNE RESPONSES IN MODELS OFTITL 3 INFLAMMATION AND AUTOIMMUNITY.REF J.IMMUNOL. V. 186 563 2011REFN ISSN 0022-1767PMID 21131419DOI 10.4049/JIMMUNOL.1000222 Variant Set […]