Assessment of Structural Intolerance and Durability
General Structure Information 3vfd SPAST human spastin aaa domain 3.3Å AUTH J.L.TAYLOR,S.R.WHITE,B.LAURING,F.J.KULLTITL CRYSTAL STRUCTURE OF THE HUMAN SPASTIN AAA DOMAIN.REF J.STRUCT.BIOL. V. 179 133 2012REFN ISSN 1047-8477PMID 22446388DOI 10.1016/J.JSB.2012.03.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3a8y BAG5 crystal structure of the complex between the bag5 bd5 and hsp70 nbd 2.3Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 2ohf OLA1 crystal structure of human ola1 in complex with amppcp 2.7Å AUTH R.KOLLER-EICHHORN,T.MARQUARDT,R.GAIL,A.WITTINGHOFER,AUTH 2 D.KOSTREWA,U.KUTAY,C.KAMBACHTITL HUMAN OLA1 DEFINES AN ATPASE SUBFAMILY IN THE OBG FAMILY OFTITL 2 GTP-BINDING PROTEINSREF J.BIOL.CHEM. V. 282 19928 2007REFN ISSN 0021-9258PMID 17430889DOI 10.1074/JBC.M700541200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2okv DTD1 c-myc dna unwinding element binding protein 2.0Å AUTH M.KEMP,B.BAE,J.P.YU,M.GHOSH,M.LEFFAK,S.K.NAIRTITL STRUCTURE AND FUNCTION OF THE C-MYC DNA-UNWINDINGTITL 2 ELEMENT-BINDING PROTEIN DUE-B.REF J.BIOL.CHEM. V. 282 10441 2007REFN ISSN 0021-9258PMID 17264083DOI 10.1074/JBC.M609632200 Variant Set Distributions Mapped Variants
General Structure Information 3dai ATAD2 crystal structure of the bromodomain of the human atad2 1.95Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3d8b FIGNL1 crystal structure of human fidgetin-like protein 1 in complex with adp 2.0Å AUTH T.KARLBERG,M.WISNIEWSKA,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,AUTH 5 M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,M.WELIN,AUTH 7 M.WIKSTROM,H.SCHULERTITL HUMAN FIDGETIN-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v5w DMC1 crystal structure of the human dmc1 protein 3.2Å AUTH T.KINEBUCHI,W.KAGAWA,R.ENOMOTO,K.TANAKA,K.MIYAGAWA,AUTH 2 T.SHIBATA,H.KURUMIZAKA,S.YOKOYAMATITL STRUCTURAL BASIS FOR OCTAMERIC RING FORMATION AND DNATITL 2 INTERACTION OF THE HUMAN HOMOLOGOUS-PAIRING PROTEIN DMC1REF MOL.CELL V. 14 363 2004REFN ISSN 1097-2765PMID 15125839DOI 10.1016/S1097-2765(04)00218-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1v5w DMC1 crystal structure of the human dmc1 protein 3.2Å AUTH T.KINEBUCHI,W.KAGAWA,R.ENOMOTO,K.TANAKA,K.MIYAGAWA,AUTH 2 T.SHIBATA,H.KURUMIZAKA,S.YOKOYAMATITL STRUCTURAL BASIS FOR OCTAMERIC RING FORMATION AND DNATITL 2 INTERACTION OF THE HUMAN HOMOLOGOUS-PAIRING PROTEIN DMC1REF MOL.CELL V. 14 363 2004REFN ISSN 1097-2765PMID 15125839DOI 10.1016/S1097-2765(04)00218-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1v5w DMC1 crystal structure of the human dmc1 protein 3.2Å AUTH T.KINEBUCHI,W.KAGAWA,R.ENOMOTO,K.TANAKA,K.MIYAGAWA,AUTH 2 T.SHIBATA,H.KURUMIZAKA,S.YOKOYAMATITL STRUCTURAL BASIS FOR OCTAMERIC RING FORMATION AND DNATITL 2 INTERACTION OF THE HUMAN HOMOLOGOUS-PAIRING PROTEIN DMC1REF MOL.CELL V. 14 363 2004REFN ISSN 1097-2765PMID 15125839DOI 10.1016/S1097-2765(04)00218-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]