3RCD.A | ERBB2

General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]

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2UZP.B | PRKCG

General Structure Information 2uzp PRKCG crystal structure of the c2 domain of human protein kinase c gamma. 2.0Å AUTH A.C.W.PIKE,A.AMOS,C.JOHANSSON,F.SOBOTT,P.SAVITSKY,AUTH 2 G.BERRIDGE,O.FEDOROV,C.UMEANO,F.GORREC,G.BUNKOCZI,AUTH 3 J.DEBRECZENI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF C2 DOMAIN OF PROTEIN KINASE C GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2JWA.A | ERBB2

General Structure Information 2jwa ERBB2 erbb2 transmembrane segment dimer spatial structure -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,P.E.VOLYNSKY,Y.S.ERMOLYUK,AUTH 2 E.N.TKACH,A.G.SOBOL,V.V.CHUPIN,M.P.KIRPICHNIKOV,AUTH 3 R.G.EFREMOV,A.S.ARSENIEVTITL SPATIAL STRUCTURE OF THE DIMERIC TRANSMEMBRANETITL 2 DOMAIN OF THE GROWTH FACTOR RECEPTOR ERBB2TITL 3 PRESUMABLY CORRESPONDING TO THE RECEPTOR ACTIVETITL 4 STATEREF J.BIOL.CHEM. V. 283 6950 2008REFN ISSN 0021-9258PMID 18178548DOI 10.1074/JBC.M709202200 Variant Set Distributions Ripley’s K […]

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2V3S.B | OXSR1

General Structure Information 2v3s OXSR1 structural insights into the recognition of substrates and activators by the osr1 kinase 1.7Å AUTH F.VILLA,J.GOEBEL,F.H.RAFIQI,M.DEAK,J.THASTRUP,AUTH 2 D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE RECOGNITION OFTITL 2 SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASEREF EMBO REP. V. 8 839 2007REFN ISSN 1469-3178PMID 17721439DOI 10.1038/SJ.EMBOR.7401048 Variant Set Distributions Mapped Variants

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3I6W.H | CHEK2

General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3BE1.A | ERBB2

General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]

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3LM0.A | STK17B

General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants

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2WWE.A | PIK3C2G

General Structure Information 2wwe PIK3C2G crystal structure of the phox homology domain of human phosphoinositide-3-kinase-c2-gamma 1.25Å AUTH A.K.ROOS,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTYENOVA,A.KOTZCH,P.KRAULIS,AUTH 5 N.MARKOVA,M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 6 H.SCHULER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,E.WAHLBERG,J.WEIGELT,AUTH 8 M.WELIN,M.WISNIEWSKA,P.NORDLUND,AUTH 9 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PHOX HOMOLOGY DOMAIN OFTITL 2 HUMAN PHOSPHOINOSITIDE-3-KINASE-C2-GAMMAREF TO BE PUBLISHEDREFN Variant Set […]

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2BUJ.A | STK16

General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]

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3HFV.A | FARS2

General Structure Information 3hfv FARS2 crystal structure of human mitochondrial phenylalanyl-trna synthetase complexed with m-tyrosine 2.6Å AUTH L.KLIPCAN,N.MOOR,N.KESSLER,M.G.SAFROTITL EUKARYOTIC CYTOSOLIC AND MITOCHONDRIALTITL 2 PHENYLALANYL-TRNA SYNTHETASES CATALYZE THE CHARGINGTITL 3 OF TRNA WITH THE META-TYROSINEREF PROC.NATL.ACAD.SCI.USA V. 106 11045 2009REFN ISSN 0027-8424PMID 19549855DOI 10.1073/PNAS.0905212106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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