Assessment of Structural Intolerance and Durability
General Structure Information 2hm2 PYDC1 solution structure of asc2 -1.0Å AUTH A.NATARAJAN,R.GHOSE,J.M.HILLTITL STRUCTURE AND DYNAMICS OF ASC2, A PYRINTITL 2 DOMAIN-ONLY PROTEIN THAT REGULATES INFLAMMATORYTITL 3 SIGNALINGREF J.BIOL.CHEM. V. 281 31863 2006REFN ISSN 0021-9258PMID 16905547DOI 10.1074/JBC.M605458200 Variant Set Distributions Mapped Variants
General Structure Information 2jk9 SPSB1 the structure of spla-ryanodine receptor domain and socs box containing 1 in complex with a par-4 peptide 1.79Å AUTH P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,AUTH 2 Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,AUTH 3 A.BULLOCKTITL STRUCTURAL BASIS FOR PAR-4 RECOGNITION BY THE SPRY DOMAIN-TITL 2 AND SOCS BOX-CONTAINING PROTEINS SPSB1, SPSB2, AND SPSB4.REF J.MOL.BIOL. V. 401 389 2010REFN ISSN 0022-2836PMID 20561531DOI […]
General Structure Information 3f7g BIRC7 structure of the bir domain from ml-iap bound to a peptidomimetic 2.3Å AUTH F.COHEN,B.ALICKE,L.O.ELLIOTT,J.A.FLYGARE,T.GONCHAROV,AUTH 2 S.F.KETELTAS,M.C.FRANKLIN,S.FRANKOVITZ,J.P.STEPHAN,V.TSUI,AUTH 3 D.VUCIC,H.WONG,W.J.FAIRBROTHERTITL ORALLY BIOAVAILABLE ANTAGONISTS OF INHIBITOR OF APOPTOSISTITL 2 PROTEINS BASED ON AN AZABICYCLOOCTANE SCAFFOLDREF J.MED.CHEM. V. 52 1723 2009REFN ISSN 0022-2623PMID 19228017DOI 10.1021/JM801450C Variant Set Distributions Mapped Variants
General Structure Information 3mqp BCL2A1 crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930 2.24Å AUTH R.GUAN,R.XIAO,L.ZHAO,T.B.ACTON,C.GELINAS,G.T.MONTELIONETITL CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3TITL 2 PEPTIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jcn BAK1 the crystal structure of bak1 – a mitochondrial apoptosis regulator 1.8Å AUTH M.MOCHE,P.STENMARK,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 R.COLLINS,A.EDWARDS,U.B.ERICSSON,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG SCHIAVONE,AUTH 4 I.JOHANSSON,T.KARLBERG,U.KOSINSKA,T.KOTENYOVA,S.LUNDGREN,AUTH 5 M.E.NILSSON,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,M.SUNDSTROM,AUTH 6 J.UPPENBERG,M.UPSTEN,A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,AUTH 7 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF BAK1 – AN APOPTOSIS TRIGGER IN THETITL 2 MITOCHONDRIAL OUTER MEMBRANEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 2ld4 CIAPIN1 solution structure of the n-terminal domain of human anamorsin -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,F.BOSCARO,A.CHATZI,AUTH 2 M.MIKOLAJCZYK,K.TOKATLIDIS,J.WINKELMANNTITL ANAMORSIN IS A [2FE-2S] CLUSTER-CONTAINING SUBSTRATE OF THETITL 2 MIA40-DEPENDENT MITOCHONDRIAL PROTEIN TRAPPING MACHINERY.REF CHEM.BIOL. V. 18 794 2011REFN ISSN 1074-5521PMID 21700214DOI 10.1016/J.CHEMBIOL.2011.03.015 Variant Set Distributions Mapped Variants
General Structure Information 3e1r CEP55 midbody targeting of the escrt machinery by a non-canonical coiled-coil in cep55 2.0Å AUTH H.H.LEE,N.ELIA,R.GHIRLANDO,J.LIPPINCOTT-SCHWARTZ,AUTH 2 J.H.HURLEYTITL MIDBODY TARGETING OF THE ESCRT MACHINERY BY ATITL 2 NONCANONICAL COILED COIL IN CEP55.REF SCIENCE V. 322 576 2008REFN ISSN 0036-8075PMID 18948538DOI 10.1126/SCIENCE.1162042 Variant Set Distributions Mapped Variants
General Structure Information 3eij PDCD4 crystal structure of pdcd4 2.8Å AUTH P.G.LOH,H.-S.YANG,M.A.WALSH,Q.WANG,X.WANG,Z.CHENG,D.LIU,AUTH 2 H.SONGTITL STRUCTURAL BASIS FOR TRANSLATIONAL INHIBITION BY THE TUMOURTITL 2 SUPPRESSOR PDCD4REF EMBO J. V. 28 274 2009REFN ISSN 0261-4189PMID 19153607DOI 10.1038/EMBOJ.2008.278 Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]