Assessment of Structural Intolerance and Durability
General Structure Information 2qz4 SPG7 human paraplegin, aaa domain in complex with adp 2.22Å AUTH T.KARLBERG,S.VAN DEN BERG,M.HAMMARSTROM,J.SAGEMARK,AUTH 2 I.JOHANSSON,L.HOLMBERG-SCHIAVONE,H.SCHULERTITL CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF THE HUMAN AAA+TITL 2 PROTEIN PARAPLEGIN/SPG7.REF PLOS ONE V. 4 E6975 2009REFN ESSN 1932-6203PMID 19841671DOI 10.1371/JOURNAL.PONE.0006975 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3nwn KIF9 crystal structure of the human kif9 motor domain in complex with adp 2.0Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gbj KIF13B crystal structure of the motor domain of kinesin kif13b bound with adp 2.1Å AUTH Y.TONG,L.SHEN,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESINTITL 2 KIF13B BOUND WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4nxt MIEF1 crystal structure of the cytosolic domain of human mid51 2.12Å AUTH V.RICHTER,C.S.PALMER,L.D.OSELLAME,A.P.SINGH,K.ELGASS,AUTH 2 D.A.STROUD,H.SESAKI,M.KVANSAKUL,M.T.RYANTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF MID51, A DYNAMINTITL 2 RECEPTOR REQUIRED FOR MITOCHONDRIAL FISSION.REF J.CELL BIOL. V. 204 477 2014REFN ISSN 0021-9525PMID 24515348DOI 10.1083/JCB.201311014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2heh KIF2C crystal structure of the kif2c motor domain (casp target) 2.15Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIF2C MOTOR DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h58 KIFC3 crystal structure of the kifc3 motor domain in complex with adp 1.85Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIFC3 MOTOR DOMAIN INTITL 2 COMPLEX WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pkj SIRT6 human sirt6 crystal structure in complex with 2-n-acetyl adp ribose 2.12Å AUTH P.W.PAN,A.DONG,J.MIN,C.ARROWSMITH,A.EDWARDSTITL HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2-N-ACETYLTITL 2 ADP RIBOSEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d8b FIGNL1 crystal structure of human fidgetin-like protein 1 in complex with adp 2.0Å AUTH T.KARLBERG,M.WISNIEWSKA,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,AUTH 5 M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,M.WELIN,AUTH 7 M.WIKSTROM,H.SCHULERTITL HUMAN FIDGETIN-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants