2H58.A | KIFC3

General Structure Information

PDB ID	2h58
HGNC Gene Label(s)	KIFC3
Structure Name	crystal structure of the kifc3 motor domain in complex with adp
Resolution	1.85Å
Reference	AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE KIFC3 MOTOR DOMAIN INTITL 2 COMPLEX WITH ADPREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	316
Number Of SNVs	69
Number Of Permutations	36621
Optimal Distance Threshold	8.0
K Statistic	0.04
p-value	0.971

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
16:57799532	COSM971899	R>C	A:451	(-3.61, 38.67, 50.54)
16:57799526	COSM971898	R>W	A:453	(-9.75, 38.38, 46.16)
16:57799511		E>K	A:458	(-16.57, 34.64, 40.86)
16:57799490		A>P	A:465	(-18.01, 43.84, 41.00)
16:57799483		N>S	A:467	(-14.25, 48.36, 44.95)
16:57799463		D>N	A:474	(-0.18, 57.76, 55.05)
16:57799433		K>E	A:484	(-24.97, 48.33, 52.91)
16:57799426		K>M	A:486	(-22.51, 52.63, 55.33)
16:57799424		P>T	A:487	(-18.62, 53.89, 55.92)
16:57799387		Q>R	A:499	(-1.43, 45.05, 43.50)
16:57799388		Q>E	A:499	(-1.43, 45.05, 43.50)
16:57799381		S>L	A:501	(3.35, 39.57, 46.18)
16:57798148		E>D	A:508	(4.93, 39.61, 57.50)
16:57798128		S>F	A:515	(12.65, 30.86, 64.73)
16:57798122		I>T	A:517	(16.30, 26.74, 62.79)
16:57798110	rs143977742	N>S	A:521	(7.09, 26.73, 68.32)
16:57798104		C>S	A:523	(1.28, 29.32, 64.13)
16:57798105		C>G	A:523	(1.28, 29.32, 64.13)
16:57798099		F>L	A:525	(-3.61, 30.38, 61.75)
16:57798078		A>T	A:532	(-10.72, 34.70, 49.63)
16:57796128		E>K	A:558	(18.91, 29.02, 56.95)
16:57796125		V>M	A:559	(19.98, 23.75, 57.36)
16:57796095		T>A	A:569	(15.73, 16.26, 60.60)
16:57796092		I>V	A:570	(13.09, 18.80, 57.89)
16:57796085		V>A	A:572	(6.14, 16.76, 56.75)
16:57796086		V>I	A:572	(6.14, 16.76, 56.75)
16:57796082		S>N	A:573	(2.72, 16.09, 58.96)
16:57796080		A>T	A:574	(-0.96, 16.15, 57.31)
16:57796076		A>V	A:575	(-4.01, 17.16, 59.33)
16:57796077		A>T	A:575	(-4.01, 17.16, 59.33)
16:57795393		G>S	A:602	(5.26, 15.09, 82.33)
16:57795354		Q>E	A:615	(12.89, 12.60, 55.98)
16:57795347		Q>L	A:617	(16.29, 16.42, 52.13)
16:57795336		D>N	A:621	(11.18, 16.02, 48.62)
16:57795326		K>R	A:624	(6.72, 14.09, 45.04)
16:57795073		F>C	A:628	(0.36, 10.90, 48.93)
16:57795065		T>P	A:631	(-4.14, 11.35, 45.36)
16:57795061		N>S	A:632	(-4.72, 10.08, 50.01)
16:57795055		T>R	A:634	(-10.17, 11.16, 46.50)
16:57795050	rs143314146	E>K	A:636	(-13.17, 3.91, 46.90)
16:57795044		T>A	A:638	(-11.42, 7.91, 52.10)
16:57795038		L>V	A:640	(-10.09, 11.98, 54.22)
16:57795019		R>H	A:646	(-17.58, 22.06, 53.94)
16:57795010		A>V	A:649	(-5.70, 22.04, 57.03)
16:57795005		L>I	A:651	(1.57, 21.46, 57.00)
16:57794999		V>M	A:653	(6.98, 21.55, 59.77)
16:57794995		T>M	A:654	(9.22, 19.06, 62.79)
16:57794989	COSM1212509	R>Q	A:656	(13.21, 16.95, 64.95)
16:57794986		G>V	A:657	(18.51, 19.47, 66.04)
16:57794971	COSM2992425	T>R	A:662	(27.36, 19.04, 72.61)
16:57794966		L>V	A:664	(22.41, 21.04, 71.99)
16:57794962		R>H	A:665	(18.87, 17.06, 70.71)
16:57794963		R>C	A:665	(18.87, 17.06, 70.71)
16:57794956	rs150459486	T>M	A:667	(12.46, 21.11, 68.59)
16:57794837		S>L	A:678	(-15.97, 31.81, 57.46)
16:57794831		R>H	A:680	(-22.87, 34.13, 58.88)
16:57794832	COSM3691069	R>C	A:680	(-22.87, 34.13, 58.88)
16:57794802		R>C	A:690	(-23.85, 22.57, 55.42)
16:57794795		R>Q	A:692	(-25.31, 18.69, 61.97)
16:57794796		R>W	A:692	(-25.31, 18.69, 61.97)
16:57794789	rs141720217	A>V	A:694	(-21.56, 25.06, 60.10)
16:57794774		K>T	A:699	(-18.75, 27.15, 67.97)
16:57794765		S>L	A:702	(-14.91, 31.21, 67.72)
16:57794744	rs147963864	A>G	A:709	(-7.29, 37.14, 72.28)
16:57794741		A>V	A:710	(-6.14, 35.62, 75.33)
16:57794736		R>C	A:712	(-2.39, 40.49, 70.82)
16:57794721		H>Y	A:717	(-8.69, 31.09, 80.77)
16:57794708		R>H	A:721	(-9.68, 22.53, 77.73)
16:57794675	COSM971897	S>L	A:732	(2.68, 26.25, 68.95)
16:57794652	rs185764293	L>F	A:740	(0.63, 35.31, 61.16)
16:57794647		M>I	A:741	(-4.31, 35.42, 61.62)
16:57794328		V>M	A:745	(-10.76, 39.87, 52.06)
16:57794311		K>N	A:750	(-20.89, 39.37, 45.69)
16:57794297		T>M	A:755	(-15.54, 41.32, 54.36)
16:57794291		Y>C	A:757	(-19.70, 38.93, 59.20)
16:57794264		R>H	A:766	(-5.30, 44.12, 66.88)
16:57794265		R>C	A:766	(-5.30, 44.12, 66.88)