General Structure Information
| PDB ID | 3pkj |
| HGNC Gene Label(s) | SIRT6 |
| Structure Name | human sirt6 crystal structure in complex with 2-n-acetyl adp ribose |
| Resolution | 2.12Å |
| Reference | AUTH P.W.PAN,A.DONG,J.MIN,C.ARROWSMITH,A.EDWARDSTITL HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2-N-ACETYLTITL 2 ADP RIBOSEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 277 |
| Number Of SNVs | 72 |
| Number Of Permutations | 36104 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.286 |
| p-value | 0.217 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 19:4182497 | D>N | A:12 | (8.46, 15.74, 23.73) | |
| 19:4182494 | K>E | A:13 | (9.96, 12.01, 23.79) | |
| 19:4180900 | COSM392901 | D>N | A:23 | (19.08, -2.53, 3.85) |
| 19:4180894 | COSM3534381 | P>S | A:25 | (22.67, -8.27, 1.62) |
| 19:4180891 | E>K | A:26 | (22.65, -6.32, -2.08) | |
| 19:4180885 | rs368678471 | L>V | A:28 | (23.98, -2.83, 2.71) |
| 19:4180878 | rs201488566 | R>Q | A:30 | (25.64, -0.58, -3.00) |
| 19:4180856 | R>S | A:37 | (30.55, 8.57, -5.23) | |
| 19:4180836 | rs352493 | S>N | A:44 | (33.82, 19.09, 3.99) |
| 19:4180833 | rs200869088 | V>A | A:45 | (33.34, 15.17, 5.63) |
| 19:4180826 | F>L | A:47 | (30.75, 11.86, 10.14) | |
| 19:4180816 | A>P | A:51 | (22.90, 6.67, 20.75) | |
| 19:4180786 | D>N | A:61 | (18.76, 3.77, 22.30) | |
| 19:4179279 | rs200388805 | P>S | A:65 | (13.42, -1.04, 20.22) |
| 19:4179263 | rs201177813 | T>N | A:70 | (10.71, 2.92, 24.54) |
| 19:4179260 | M>T | A:71 | (11.49, 0.20, 28.00) | |
| 19:4179251 | rs199934255 | R>L | A:74 | (6.45, -0.06, 29.03) |
| 19:4179231 | D>N | A:81 | (25.13, -4.54, 28.93) | |
| 19:4179227 | T>N | A:82 | (28.39, -1.17, 30.54) | |
| 19:4179215 | S>T | A:86 | (33.52, -0.20, 31.35) | |
| 19:4179212 | A>V | A:87 | (32.91, 1.42, 28.06) | |
| 19:4179203 | T>M | A:90 | (32.51, 1.15, 18.83) | |
| 19:4179188 | A>V | A:95 | (36.59, 4.78, 12.30) | |
| 19:4179189 | A>T | A:95 | (36.59, 4.78, 12.30) | |
| 19:4179178 | rs199587590 | Q>H | A:98 | (41.99, 6.15, 10.95) |
| 19:4179170 | rs559817229 | R>H | A:101 | (44.37, 9.31, 13.20) |
| 19:4179168 | V>L | A:102 | (43.41, 10.13, 6.96) | |
| 19:4179159 | L>F | A:105 | (36.60, 13.62, 9.64) | |
| 19:4179155 | rs201136536 | R>H | A:106 | (36.42, 19.97, 9.33) |
| 19:4179134 | V>A | A:113 | (26.50, 12.08, 27.22) | |
| 19:4179135 | V>L | A:113 | (26.50, 12.08, 27.22) | |
| 19:4179116 | COSM3701500 | R>H | A:119 | (37.28, 7.46, 27.49) |
| 19:4177130 | K>R | A:126 | (37.36, 18.35, 15.48) | |
| 19:4177113 | G>R | A:132 | (27.72, 16.72, 26.60) | |
| 19:4177106 | M>T | A:134 | (28.91, 11.73, 31.86) | |
| 19:4177101 | V>M | A:136 | (33.49, 16.94, 31.09) | |
| 19:4177088 | A>V | A:140 | (31.86, 29.01, 36.36) | |
| 19:4177083 | C>R | A:142 | (37.44, 30.09, 33.61) | |
| 19:4177080 | K>E | A:143 | (35.50, 27.80, 31.24) | |
| 19:4177076 | T>M | A:144 | (38.60, 25.54, 32.33) | |
| 19:4175923 | rs114189165 | R>Q | A:148 | (38.10, 14.57, 35.81) |
| 19:4175882 | rs201293003 | R>W | A:162 | (35.16, 18.11, 42.25) |
| 19:4175746 | rs577060398 | R>M | A:180 | (28.64, 24.52, 37.69) |
| 19:4175743 | rs199592512 | D>V | A:181 | (27.53, 19.32, 35.13) |
| 19:4175722 | D>V | A:188 | (19.45, 23.62, 30.11) | |
| 19:4175711 | rs201065738 | D>N | A:192 | (27.34, 29.28, 23.08) |
| 19:4175699 | A>S | A:196 | (28.98, 27.60, 16.52) | |
| 19:4175690 | rs201495361 | D>N | A:199 | (26.13, 25.98, 12.35) |
| 19:4175687 | rs149957544 | E>K | A:200 | (30.03, 26.16, 10.70) |
| 19:4175681 | S>G | A:202 | (27.36, 21.83, 9.04) | |
| 19:4175144 | A>T | A:205 | (29.64, 20.94, 4.24) | |
| 19:4175141 | rs558969933 | D>N | A:206 | (30.64, 18.73, 0.63) |
| 19:4175137 | L>R | A:207 | (29.25, 14.87, 2.93) | |
| 19:4175116 | S>L | A:214 | (16.48, 10.17, 15.35) | |
| 19:4175104 | rs75244031 | R>Q | A:218 | (16.35, 20.57, 18.27) |
| 19:4175105 | R>W | A:218 | (16.35, 20.57, 18.27) | |
| 19:4175096 | rs191314480 | G>R | A:221 | (18.83, 17.56, 13.73) |
| 19:4175071 | R>H | A:229 | (19.30, 23.84, 3.01) | |
| 19:4175068 | rs550563777 | R>Q | A:230 | (25.54, 26.12, 1.72) |
| 19:4175059 | rs147362434 | R>H | A:233 | (25.00, 15.16, -2.11) |
| 19:4175060 | rs200860440 | R>C | A:233 | (25.00, 15.16, -2.11) |
| 19:4175048 | rs370737205 | V>I | A:237 | (23.24, 5.58, 8.89) |
| 19:4174936 | H>R | A:247 | (15.70, 16.76, 2.03) | |
| 19:4174925 | rs368321168 | R>C | A:251 | (19.05, 5.97, 3.08) |
| 19:4174910 | rs199584212 | V>I | A:256 | (26.69, 1.70, 12.51) |
| 19:4174903 | rs200486957 | E>A | A:258 | (27.72, -4.17, 8.68) |
| 19:4174904 | rs201007105 COSM712797 |
E>K | A:258 | (27.72, -4.17, 8.68) |
| 19:4174897 | M>K | A:260 | (31.75, 2.52, 9.29) | |
| 19:4174894 | T>I | A:261 | (33.36, -2.26, 8.70) | |
| 19:4174891 | rs201745114 | R>Q | A:262 | (32.60, -1.66, 4.71) |
| 19:4174892 | R>W | A:262 | (32.60, -1.66, 4.71) | |
| 19:4174859 | rs74317014 | A>T | A:273 | (43.63, 0.17, 18.34) |
| 19:4174849 | G>D | A:276 | (42.46, 3.14, 26.28) | |
| 19:4174850 | G>S | A:276 | (42.46, 3.14, 26.28) | |
| 19:4174844 | R>C | A:278 | (42.71, 8.91, 25.59) | |
| 19:4174820 | P>A | A:286 | (47.11, 14.98, 7.67) | |
| 19:4174813 | rs370210332 | P>R | A:288 | (49.51, 8.85, 5.28) |
| 19:4174811 | R>C | A:289 | (46.21, 8.05, 2.40) | |
| 19:4174807 | P>L | A:290 | (44.83, 5.58, 0.41) |