Assessment of Structural Intolerance and Durability
General Structure Information 1r4x COPG1 crystal structure analys of the gamma-copi appendage domain 1.9Å AUTH P.J.WATSON,G.FRIGERIO,B.M.COLLINS,R.DUDEN,D.J.OWENTITL GAMMA-COP APPENDAGE DOMAIN – STRUCTURE AND FUNCTIONREF TRAFFIC V. 5 79 2004REFN ISSN 1398-9219PMID 14690497DOI 10.1111/J.1600-0854.2004.00158.X Variant Set Distributions Mapped Variants
General Structure Information 3l82 FBXO4 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3ua9 TNKS2 crystal structure of human tankyrase 2 in complex with a selective inhibitor 2.15Å AUTH M.NARWAL,H.VENKANNAGARI,L.LEHTIOTITL STRUCTURAL BASIS OF SELECTIVE INHIBITION OF HUMANTITL 2 TANKYRASES.REF J.MED.CHEM. V. 55 1360 2012REFN ISSN 0022-2623PMID 22233320DOI 10.1021/JM201510P Variant Set Distributions Mapped Variants
General Structure Information 2crw ARFGAP3 solution structure of the arfgap domain of adp-ribosylation factor gtpaseactivating protein 3 (arfgap 3) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ARFGAP DOMAIN OFTITL 2 ADP-RIBOSYLATION FACTOR GTPASEACTIVATING PROTEIN 3TITL 3 (ARFGAP 3)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3pkj SIRT6 human sirt6 crystal structure in complex with 2-n-acetyl adp ribose 2.12Å AUTH P.W.PAN,A.DONG,J.MIN,C.ARROWSMITH,A.EDWARDSTITL HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2-N-ACETYLTITL 2 ADP RIBOSEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kuo APLF structure and identification of adp-ribose recognition motifs of aplf and role in the dna damage response -1.0Å AUTH G.Y.LI,R.D.MCCULLOCH,A.FENTON,M.CHEUNG,L.MENG,M.IKURA,AUTH 2 C.A.KOCHTITL STRUCTURE AND IDENTIFICATION OF ADP-RIBOSE RECOGNITIONTITL 2 MOTIFS OF APRATAXIN PNK-LIKE FACTOR (APLF) REQUIRED FOR THETITL 3 INTERACTION WITH SITES OF DNA DAMAGE RESPONSEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3v2b PARP15 human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose 2.2Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3se2 PARP14 human poly(adp-ribose) polymerase 14 (parp14/artd8) – catalytic domain in complex with 6(5h)-phenanthridinone 2.3Å AUTH E.WAHLBERG,T.KARLBERG,E.KOUZNETSOVA,N.MARKOVA,A.MACCHIARULO,AUTH 2 A.G.THORSELL,E.POL,A.FROSTELL,T.EKBLAD,D.ONCU,B.KULL,AUTH 3 G.M.ROBERTSON,R.PELLICCIARI,H.SCHULER,J.WEIGELTTITL FAMILY-WIDE CHEMICAL PROFILING AND STRUCTURAL ANALYSIS OFTITL 2 PARP AND TANKYRASE INHIBITORS.REF NAT.BIOTECHNOL. V. 30 283 2012REFN ISSN 1087-0156PMID 22343925DOI 10.1038/NBT.2121 Variant Set Distributions Mapped Variants
General Structure Information 2xns GNAI1 crystal structure of human g alpha i1 bound to a designed helical peptide derived from the goloco motif of rgs14 3.41Å AUTH D.W.SAMMOND,D.E.BOSCH,G.L.BUTTERFOSS,C.PURBECK,AUTH 2 M.MACHIUS,D.P.SIDEROVSKI,B.KUHLMANTITL COMPUTATIONAL DESIGN OF THE SEQUENCE AND STRUCTURETITL 2 OF A PROTEIN-BINDING PEPTIDE.REF J.AM.CHEM.SOC. V. 133 4190 2011REFN ISSN 0002-7863PMID 21388199DOI 10.1021/JA110296Z Variant Set Distributions Ripley’s […]