Assessment of Structural Intolerance and Durability
General Structure Information 3fkc ZBTB33 crystal structure of human zinc finger and btb domain containing 33 1.7Å AUTH P.FILIPPAKOPOULOS,A.BULLOCK,T.KEATES,N.BURGESS-BROWN,AUTH 2 J.MUNIZ,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ZINC FINGER AND BTB DOMAINTITL 2 CONTAINING 33REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2aft SUMF1 formylglycine generating enzyme c336s mutant 1.66Å AUTH D.ROESER,A.PREUSSER-KUNZE,B.SCHMIDT,K.GASOW,J.G.WITTMANN,AUTH 2 T.DIERKS,K.VON FIGURA,M.G.RUDOLPHTITL A GENERAL BINDING MECHANISM FOR ALL HUMAN SULFATASES BY THETITL 2 FORMYLGLYCINE-GENERATING ENZYMEREF PROC.NATL.ACAD.SCI.USA V. 103 81 2006REFN ISSN 0027-8424PMID 16368756DOI 10.1073/PNAS.0507592102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o47 ARFGAP1 crystal structure of arfgap1-arf1 fusion protein 2.8Å AUTH H.WANG,Y.TONG,L.NEDYALKOVA,W.TEMPEL,X.GUAN,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF ARFGAP1-ARF1 FUSION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c52 NCOA1 structural diversity in cbp p160 complexes -1.0Å AUTH L.C.WATERS,B.YUE,V.VEVERKA,P.S.RENSHAW,J.BRAMHAM,AUTH 2 S.MATSUDA,T.FRENKIEL,G.KELLY,F.W.MUSKETT,M.D.CARR,AUTH 3 D.M.HEERYTITL STRUCTURAL DIVERSITY IN P160/CREB-BINDING PROTEINTITL 2 COACTIVATOR COMPLEXES.REF J.BIOL.CHEM. V. 281 14787 2006REFN ISSN 0021-9258PMID 16540468DOI 10.1074/JBC.M600237200 Variant Set Distributions Mapped Variants
General Structure Information 3eap ARHGAP11A crystal structure of the rhogap domain of arhgap11a 2.3Å AUTH Y.SHEN,L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pp2 ARHGAP27 crystal structure of the pleckstrin homology domain of arhgap27 1.42Å AUTH L.SHEN,W.TEMPEL,Y.TONG,L.NEDYALKOVA,Y.LI,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OFTITL 2 ARHGAP27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kkt ATXN7L3 solution structure of the sca7 domain of human ataxin-7-l3 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3a77 IRF3 the crystal structure of phosphorylated irf-3 1.8Å AUTH K.TAKAHASI,M.HORIUCHI,K.FUJII,S.NAKAMURA,N.N.NODA,AUTH 2 M.YONEYAMA,T.FUJITA,F.INAGAKITITL SER386 PHOSPHORYLATION OF TRANSCRIPTION FACTOR IRF-3 INDUCESTITL 2 DIMERIZATION AND ASSOCIATION WITH CBP/P300 WITHOUT OVERALLTITL 3 CONFORMATIONAL CHANGE.REF GENES CELLS V. 15 901 2010REFN ISSN 1356-9597PMID 20604809DOI 10.1111/J.1365-2443.2010.01427.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2hv7 PPP2R4 crystal structure of phosphotyrosyl phosphatase activator bound to atpgammas 2.5Å AUTH Y.CHAO,Y.XING,Y.CHEN,Y.XU,Z.LIN,Z.LI,P.D.JEFFREY,AUTH 2 J.B.STOCK,Y.SHITITL STRUCTURE AND MECHANISM OF THE PHOSPHOTYROSYLTITL 2 PHOSPHATASE ACTIVATOR.REF MOL.CELL V. 23 535 2006REFN ISSN 1097-2765PMID 16916641DOI 10.1016/J.MOLCEL.2006.07.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants