Assessment of Structural Intolerance and Durability
General Structure Information 4iqm PUS1 crystal structure of the catalytic domain of human pus1 1.8Å AUTH N.CZUDNOCHOWSKI,A.L.WANG,J.FINER-MOORE,R.M.STROUDTITL IN HUMAN PSEUDOURIDINE SYNTHASE 1 (HPUS1), A C-TERMINALTITL 2 HELICAL INSERT BLOCKS TRNA FROM BINDING IN THE SAMETITL 3 ORIENTATION AS IN THE PUS1 BACTERIAL HOMOLOGUE TRUA,TITL 4 CONSISTENT WITH THEIR DIFFERENT TARGET SELECTIVITIES.REF J.MOL.BIOL. V. 425 3875 […]
General Structure Information 4cff PRKAB1 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Mapped Variants
General Structure Information 2cxk CAMTA1 crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1) 1.85Å AUTH A.A.PIOSZAK,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE TIG DOMAIN OF HUMANTITL 2 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1TITL 3 (CAMTA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qwl TBC1D7 crystal structure of human tbc1 domain family member 7 1.9Å AUTH X.GUAN,W.TEMPEL,Y.TONG,A.K.WERNIMONT,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3mqi EBF1 human early b-cell factor 1 (ebf1) ipt/tig domain 2.3Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 1wi1 CADPS solution structure of the ph domain of human calcium- dependent activator protein for secretion (caps) -1.0Å AUTH M.YONEYAMA,K.IZUMI,M.YOSHIDA,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF HUMANTITL 2 CALCIUM-DEPENDENT ACTIVATOR PROTEIN FOR SECRETIONTITL 3 (CAPS)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lyr EBF1 human early b-cell factor 1 (ebf1) dna-binding domain 2.51Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]
General Structure Information 3i3t USP21 crystal structure of covalent ubiquitin-usp21 complex 2.59Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2qq8 TBC1D14 crystal structure of the putative rabgap domain of human tbc1 domain family member 14 2.0Å AUTH Y.TONG,W.TEMPEL,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OFTITL 2 HUMAN TBC1 DOMAIN FAMILY MEMBER 14.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3dzx TBC1D22B crystal structure of the rabgap domain of human tbc1d22b 2.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,Y.SHEN,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF HUMAN TBC1D22BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants