General Structure Information
| PDB ID | 3a77 |
| HGNC Gene Label(s) | IRF3 |
| Structure Name | the crystal structure of phosphorylated irf-3 |
| Resolution | 1.8Å |
| Reference | AUTH K.TAKAHASI,M.HORIUCHI,K.FUJII,S.NAKAMURA,N.N.NODA,AUTH 2 M.YONEYAMA,T.FUJITA,F.INAGAKITITL SER386 PHOSPHORYLATION OF TRANSCRIPTION FACTOR IRF-3 INDUCESTITL 2 DIMERIZATION AND ASSOCIATION WITH CBP/P300 WITHOUT OVERALLTITL 3 CONFORMATIONAL CHANGE.REF GENES CELLS V. 15 901 2010REFN ISSN 1356-9597PMID 20604809DOI 10.1111/J.1365-2443.2010.01427.X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 231 |
| Number Of SNVs | 62 |
| Number Of Permutations | 9588 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.104 |
| p-value | 0.294 |
COSMIC
| Number Of Residues | 231 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.254 |
| p-value | 0.721 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
