Assessment of Structural Intolerance and Durability
General Structure Information 2wfn FLNA filamin a actin binding domain 3.2Å AUTH S.RUSKAMO,J.YLANNETITL STRUCTURE OF THE HUMAN FILAMIN A ACTIN-BINDING DOMAINREF ACTA CRYSTALLOGR.,SECT.D V. 65 1217 2009REFN ISSN 0907-4449PMID 19923718DOI 10.1107/S0907444909037330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3es6 PIP crystal structure of the novel complex formed between zinc 2- glycoprotein (zag) and prolactin inducible protein (pip) from human seminal plasma 3.23Å AUTH M.I.HASSAN,S.BILGRAMI,V.KUMAR,N.SINGH,S.YADAV,P.KAUR,AUTH 2 T.P.SINGHTITL CRYSTAL STRUCTURE OF THE NOVEL COMPLEX FORMED BETWEEN ZINCTITL 2 ALPHA2-GLYCOPROTEIN (ZAG) AND PROLACTIN-INDUCIBLE PROTEINTITL 3 (PIP) FROM HUMAN SEMINAL PLASMAREF J.MOL.BIOL. V. 384 […]
General Structure Information 1tr2 VCL crystal structure of human full-length vinculin (residues 1- 1066) 2.9Å AUTH R.A.BORGON,C.VONRHEIN,G.BRICOGNE,P.R.BOIS,T.IZARDTITL CRYSTAL STRUCTURE OF HUMAN VINCULINREF STRUCTURE V. 12 1189 2004REFN ISSN 0969-2126PMID 15242595DOI 10.1016/J.STR.2004.05.00 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2eyi ACTN1 crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.7 angstrom resolution 1.7Å AUTH E.BORREGO-DIAZ,F.KERFF,S.H.LEE,F.FERRON,Y.LI,AUTH 2 R.DOMINGUEZTITL CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OFTITL 2 ALPHA-ACTININ 1: EVALUATING TWO COMPETINGTITL 3 ACTIN-BINDING MODELS.REF J.STRUCT.BIOL. V. 155 230 2006REFN ISSN 1047-8477PMID 16698282DOI 10.1016/J.JSB.2006.01.013 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 3ffn GSN crystal structure of calcium-free human gelsolin 3.0Å AUTH S.NAG,Q.MA,H.WANG,S.CHUMNARNSILPA,W.L.LEE,AUTH 2 M.LARSSON,B.KANNAN,M.HERNANDEZ-VALLADARES,AUTH 3 L.D.BURTNICK,R.C.ROBINSONTITL CA2+ BINDING BY DOMAIN 2 PLAYS A CRITICAL ROLE INTITL 2 THE ACTIVATION AND STABILIZATION OF GELSOLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13713 2009REFN ISSN 0027-8424PMID 19666512DOI 10.1073/PNAS.0812374106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fg7 VIL1 the crystal structure of villin domain 6 2.0Å AUTH H.WANG,S.CHUMNARNSILPA,A.LOONCHANTA,Q.LI,Y.M.KUAN,AUTH 2 S.ROBINE,M.LARSSON,I.MIHALEK,L.D.BURTNICK,AUTH 3 R.C.ROBINSONTITL HELIX-STRAIGHTENING AS AN ACTIVATION MECHANISM INTITL 2 THE GELSOLIN SUPERFAMILY OF ACTIN REGULATORYTITL 3 PROTEINSREF J.BIOL.CHEM. V. 284 21265 2009REFN ISSN 0021-9258PMID 19491107DOI 10.1074/JBC.M109.019760 Variant Set Distributions Mapped Variants
General Structure Information 2k6m SVIL solution structure of human supervillin headpiece -1.0Å AUTH J.W.BROWN,D.VARDAR-ULU,C.J.MCKNIGHTTITL HOW TO ARM A SUPERVILLIN: DESIGNING F-ACTIN BINDINGTITL 2 ACTIVITY INTO SUPERVILLIN HEADPIECE.REF J.MOL.BIOL. V. 393 608 2009REFN ISSN 0022-2836PMID 19683541DOI 10.1016/J.JMB.2009.08.018 Variant Set Distributions Mapped Variants