Assessment of Structural Intolerance and Durability
General Structure Information 3fg6 SCIN structure of the c-terminus of adseverin 3.0Å AUTH S.CHUMNARNSILPA,W.L.LEE,S.NAG,B.KANNAN,M.LARSSON,AUTH 2 L.D.BURTNICK,R.C.ROBINSONTITL THE CRYSTAL STRUCTURE OF THE C-TERMINUS OF ADSEVERIN REVEALSTITL 2 THE ACTIN-BINDING INTERFACE.REF PROC.NATL.ACAD.SCI.USA V. 106 13719 2009REFN ISSN 0027-8424PMID 19666531DOI 10.1073/PNAS.0812383106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dad FHOD1 crystal structure of the n-terminal regulatory domains of the formin fhod1 2.3Å AUTH A.SCHULTE,B.STOLP,A.SCHONICHEN,O.PYLYPENKO,A.RAK,AUTH 2 O.T.FACKLER,M.GEYERTITL THE HUMAN FORMIN FHOD1 CONTAINS A BIPARTITETITL 2 STRUCTURE OF FH3 AND GTPASE-BINDING DOMAINSTITL 3 REQUIRED FOR ACTIVATION.REF STRUCTURE V. 16 1313 2008REFN ISSN 0969-2126PMID 18786395DOI 10.1016/J.STR.2008.06.008 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bin EPB41L3 structure of the dal-1 and tslc1 (372-383) complex 2.3Å AUTH R.D.BUSAM,A.-G.THORSELL,A.FLORES,M.HAMMARSTROM,C.PERSSON,AUTH 2 B.OBRINK,B.M.HALLBERGTITL STRUCTURAL BASIS OF TUMOR SUPPRESSOR IN LUNG CANCER 1TITL 2 (TSLC1) BINDING TO DIFFERENTIALLY EXPRESSED INTITL 3 ADENOCARCINOMA OF THE LUNG (DAL-1/4.1B)REF J.BIOL.CHEM. V. 286 4511 2011REFN ISSN 0021-9258PMID 21131357DOI 10.1074/JBC.M110.174011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants
General Structure Information 2kkq MYOT solution nmr structure of the ig-like c2-type 2 domain of human myotilin. northeast structural genomics target hr3158. -1.0Å AUTH P.ROSSI,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE IG-LIKE C2-TYPE 2TITL 2 DOMAIN OF HUMAN MYOTILIN. NORTHEAST STRUCTURALTITL 3 GENOMICS TARGET HR3158.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1×67 DBNL solution structure of the cofilin homology domain of hip-55 (drebrin-like protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.SATO,AUTH 2 M.INOUE,S.WATANABE,Y.HAYASHIZAKI,A.TANAKA,T.KIGAWA,AUTH 3 S.YOKOYAMATITL NMR SOLUTION STRUCTURES OF ACTIN DEPOLYMERIZINGTITL 2 FACTOR HOMOLOGY DOMAINS.REF PROTEIN SCI. V. 18 2384 2009REFN ISSN 0961-8368PMID 19768801DOI 10.1002/PRO.248 Variant Set Distributions Mapped Variants
General Structure Information 1v05 FLNC dimerization of human filamin c: crystal structure of the domain 24 1.43Å AUTH R.PUDAS,T.-R.KIEMA,P.J.G.BUTLER,M.STEWART,J.YLANNETITL STRUCTURAL BASIS FOR VERTEBRATE FILAMINTITL 2 DIMERIZATIONREF STRUCTURE V. 13 111 2005REFN ISSN 0969-2126PMID 15642266DOI 10.1016/J.STR.2004.10.014 Variant Set Distributions Mapped Variants
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3i35 LASP1 human sh3 domain of protein lasp1 1.4Å AUTH M.I.SIPONEN,A.K.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,M.MOCHE,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN SH3 DOMAIN OF PROTEIN LASP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants