General Structure Information 4im6 NLRP1 lrr domain from human nlrp1 1.65Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
Assessment of Structural Intolerance and Durability
General Structure Information 4im6 NLRP1 lrr domain from human nlrp1 1.65Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yhn RILP structure basis of rilp recruitment by rab7 3.0Å AUTH M.WU,T.WANG,E.LOH,W.HONG,H.SONGTITL STRUCTURAL BASIS FOR RECRUITMENT OF RILP BY SMALL GTPASETITL 2 RAB7.REF EMBO J. V. 24 1491 2005REFN ISSN 0261-4189PMID 15933719DOI 10.1038/SJ.EMBOJ.7600643 Variant Set Distributions Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yud YTHDC1 solution structure of the yth domain in yth domain- containing protein 1 (putative splicing factor yt521) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE YTH DOMAIN IN YTHTITL 2 DOMAIN-CONTAINING PROTEIN 1 (PUTATIVE SPLICINGTITL 3 FACTOR YT521)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1dgv CIB1 homology-based model of apo cib (calcium-and integrin- binding protein) -1.0Å AUTH P.M.HWANG,H.J.VOGELTITL STRUCTURES OF THE PLATELET CALCIUM- ANDTITL 2 INTEGRIN-BINDING PROTEIN AND THE ALPHAIIB-INTEGRINTITL 3 CYTOPLASMIC DOMAIN SUGGEST A MECHANISM FORTITL 4 CALCIUM-REGULATED RECOGNITION; HOMOLOGY MODELLINGTITL 5 AND NMR STUDIES.REF J.MOL.RECOG. V. 13 83 2000REFN ISSN 0952-3499PMID 10822252DOI 10.1002/(SICI)1099-1352(200003/04)13:23.3.CO;2-1 Variant […]
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 3d34 SPON2 structure of the f-spondin domain of mindin 1.8Å AUTH Y.LI,C.CAO,W.JIA,L.YU,M.MO,Q.WANG,Y.HUANG,J.M.LIM,AUTH 2 M.ISHIHARA,L.WELLS,P.AZADI,H.ROBINSON,Y.W.HE,AUTH 3 L.ZHANG,R.A.MARIUZZATITL STRUCTURE OF THE F-SPONDIN DOMAIN OF MINDIN, ANTITL 2 INTEGRIN LIGAND AND PATTERN RECOGNITION MOLECULE.REF EMBO J. V. 28 286 2009REFN ISSN 0261-4189PMID 19153605DOI 10.1038/EMBOJ.2008.288 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4b91 DPYSL5 crystal structure of truncated human crmp-5 1.7Å AUTH R.PONNUSAMY,B.LOHKAMPTITL INSIGHTS INTO THE OLIGOMERIZATION OF CRMPS: CRYSTALTITL 2 STRUCTURE OF HUMAN COLLAPSIN RESPONSE MEDIATOR PROTEIN 5.REF J.NEUROCHEM. V. 125 855 2013REFN ISSN 0022-3042PMID 23373749DOI 10.1111/JNC.12188 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j67 TLR10 the tir domain of human toll-like receptor 10 (tlr10) 2.2Å AUTH T.NYMAN,P.STENMARK,S.FLODIN,I.JOHANSSON,M.HAMMARSTROM,AUTH 2 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF THE HUMAN TOLL-LIKE RECEPTOR 10TITL 2 CYTOPLASMIC DOMAIN REVEALS A PUTATIVE SIGNALING DIMER.REF J.BIOL.CHEM. V. 283 11861 2008REFN ISSN 0021-9258PMID 18332149DOI 10.1074/JBC.C800001200 Variant Set Distributions Mapped Variants