Assessment of Structural Intolerance and Durability
General Structure Information 2dnp RBM14 solution structure of rna binding domain 2 in rna-binding protein 14 -1.0Å AUTH M.KUSUHARA,K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,AUTH 2 T.TERADA,M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN 2 INTITL 2 RNA-BINDING PROTEIN 14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p1a PKMYT1 structure of human membrane-associated tyrosine- and threonine- specific cdc2-inhibitory kinase myt1 (pkmyt1) 1.7Å AUTH A.CHAIKUAD,J.ESWARAN,O.FEDOROV,C.D.O.COOPER,T.KROELER,AUTH 2 M.VOLLMAR,T.KROJER,G.BERRIDGE,J.R.C.MUNIZ,A.C.W.PIKE,AUTH 3 F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 4 S.KNAPPTITL STRUCTURE OF HUMAN MEMBRANE-ASSOCIATED TYROSINE- ANDTITL 2 THREONINE-SPECIFIC CDC2-INHIBITORY KINASE MYT1 (PKMYT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yse MAGI1 solution structure of the second ww domain from the human membrane-associated guanylate kinase, ww and pdz domain- containing protein 1. magi-1 -1.0Å AUTH S.OHNISHI,M.SATO,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND WW DOMAIN FROMTITL 2 THE HUMAN MEMBRANE-ASSOCIATED GUANYLATE KINASE, WWTITL 3 AND PDZ DOMAIN-CONTAINING PROTEIN 1. MAGI-1REF TO BE […]
General Structure Information 2pny IDI2 structure of human isopentenyl-diphosphate delta-isomerase 2 1.81Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE HUMAN ISOPENTENYL-DIPHOSPHATETITL 2 DELTA-ISOMERASE 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gfv PTPN18 ptpn18 in complex with her2-py1196 phosphor-peptides 2.1Å AUTH H.M.WANG,F.YANG,Y.J.DU,D.X.YANG,Y.ZHANG,X.YU,J.P.SUNTITL PTPN18-HER2 PEPTIDESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yxm PECR crystal structure of peroxisomal trans 2-enoyl coa reductase 1.9Å AUTH A.JANSSON,S.NG,C.ARROWSMITH,S.SHARMA,A.M.EDWARDS,AUTH 2 F.VON DELFT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF PERIXOMAL TRANS 2-ENOYL COATITL 2 REDUCTASE (PECRA)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4jt6 MLST8 structure of mtordeltan-mlst8-pi-103 complex 3.6Å AUTH H.YANG,D.G.RUDGE,J.D.KOOS,B.VAIDIALINGAM,H.J.YANG,AUTH 2 N.P.PAVLETICHTITL MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.REF NATURE V. 497 217 2013REFN ISSN 0028-0836PMID 23636326DOI 10.1038/NATURE12122 Variant Set Distributions Mapped Variants
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 2enp SYT17 solution structure of the first c2 domain from human b/k protein -1.0Å AUTH H.ENDO,T.NAGASHIMA,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN FROMTITL 2 HUMAN B/K PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants