Assessment of Structural Intolerance and Durability
General Structure Information 2w3c USO1 globular head region of the human general vesicular transport factor p115 2.22Å AUTH H.STRIEGL,Y.ROSKE,D.KUMMEL,U.HEINEMANNTITL UNUSUAL ARMADILLO FOLD IN THE HUMAN GENERAL VESICULARTITL 2 TRANSPORT FACTOR P115REF PLOS ONE V. 4 E4656 2009REFN ISSN 1932-6203PMID 19247479DOI 10.1371/JOURNAL.PONE.0004656 Variant Set Distributions Mapped Variants
General Structure Information 4chb KLHL2 crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide 1.56Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2ee6 FLNB solution structure of the 21th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 21TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4jih AKR1B10 crystal structure of akr1b10 complexed with nadp+ and epalrestat 2.3Å AUTH L.ZHANG,H.ZHANG,Y.ZHAO,Z.LI,S.CHEN,J.ZHAI,Y.CHEN,W.XIE,AUTH 2 Z.WANG,Q.LI,X.ZHENG,X.HUTITL INHIBITOR SELECTIVITY BETWEEN ALDO-KETO REDUCTASETITL 2 SUPERFAMILY MEMBERS AKR1B10 AND AKR1B1: ROLE OF TRP112TITL 3 (TRP111).REF FEBS LETT. V. 587 3681 2013REFN ISSN 0014-5793PMID 24100137DOI 10.1016/J.FEBSLET.2013.09.031 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ct3 SORBS3 solution structure of the sh3 domain of the vinexin protein -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THETITL 2 VINEXIN PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cpm SPAG7 solution structure of the r3h domain of human sperm- associated antigen 7 -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE R3H DOMAIN OF HUMANTITL 2 SPERM-ASSOCIATED ANTIGEN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2v1n KIN solution structure of the region 51-160 of human kin17 reveals a winged helix fold -1.0Å AUTH L.CARLIER,A.LE MAIRE,M.GONDRY,L.GUILHAUDIS,AUTH 2 I.MILAZZO,D.DAVOUST,J.COUPRIE,B.GILQUIN,AUTH 3 S.ZINN-JUSTINTITL SOLUTION STRUCTURE OF THE REGION 51-160 OF HUMANTITL 2 KIN17 REVEALS AN ATYPICAL WINGED HELIX DOMAINREF PROTEIN SCI. V. 16 2750 2007REFN ISSN 0961-8368PMID 18029424DOI 10.1110/PS.073079107 Variant Set […]
General Structure Information 2dmb FLNB solution structure of the 15th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 15TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2qqk NRP2 neuropilin-2 a1a2b1b2 domains in complex with a semaphorin-blocking fab 2.75Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]