Assessment of Structural Intolerance and Durability
General Structure Information 3qve HBP1 crystal structure of human hmg box-containing protein 1, hbp1 2.04Å AUTH A.CHAIKUAD,E.KRYSZTOFINSKA,R.COCKING,M.VOLLMAR,W.W.YUE,AUTH 2 T.KROJER,E.UGOCHUKWU,P.FILIPPAKOPOULOS,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,C.BOUNTRA,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUMTITL CRYSTAL STRUCTURE OF HUMAN HMG BOX-CONTAINING PROTEIN 1,TITL 2 HBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nzj REM1 the crystal structure of rem1 in complex with gdp 2.5Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,E.UGOCHUKWU,J.M.ELKINS,AUTH 2 M.SOUNDARARAJAN,X.YANG,F.GORREC,C.UMEANO,E.SALAH,N.BURGESS,AUTH 3 C.JOHANSSON,G.BERRIDGE,O.GILEADI,J.BRAY,B.MARSDEN,S.WATTS,AUTH 4 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,M.SUNDSTROM,AUTH 5 D.DOYLETITL THE CRYSTAL STRUCTURE OF REM1 IN COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3zyw GLRX3 crystal structure of the first glutaredoxin domain of human glutaredoxin 3 (glrx3) 1.84Å AUTH M.VOLLMAR,C.JOHANSSON,R.COCKING,T.KROJER,J.R.C.MUNIZ,AUTH 2 K.L.KAVANAGH,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE FIRST GLUTAREDOXIN DOMAIN OF HUMANTITL 2 GLUTAREDOXIN 3 (GLRX3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k6m SVIL solution structure of human supervillin headpiece -1.0Å AUTH J.W.BROWN,D.VARDAR-ULU,C.J.MCKNIGHTTITL HOW TO ARM A SUPERVILLIN: DESIGNING F-ACTIN BINDINGTITL 2 ACTIVITY INTO SUPERVILLIN HEADPIECE.REF J.MOL.BIOL. V. 393 608 2009REFN ISSN 0022-2836PMID 19683541DOI 10.1016/J.JMB.2009.08.018 Variant Set Distributions Mapped Variants
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3q32 JAK2 structure of janus kinase 2 with a pyrrolotriazine inhibitor 2.5Å AUTH L.S.HARIKRISHNAN,M.G.KAMAU,H.WAN,J.A.INGHRIM,K.ZIMMERMANN,AUTH 2 X.SANG,H.A.MASTALERZ,W.L.JOHNSON,G.ZHANG,L.J.LOMBARDO,AUTH 3 M.A.POSS,G.L.TRAINOR,J.S.TOKARSKI,M.V.LORENZI,D.YOU,AUTH 4 M.M.GOTTARDIS,K.F.BALDWIN,J.LIPPY,D.S.NIRSCHL,R.QIU,AUTH 5 A.V.MILLER,J.KHAN,J.S.SACK,A.V.PURANDARETITL PYRROLO[1,2-F]TRIAZINES AS JAK2 INHIBITORS: ACHIEVINGTITL 2 POTENCY AND SELECTIVITY FOR JAK2 OVER JAK3.REF BIOORG.MED.CHEM.LETT. V. 21 1425 2011REFN ISSN 0960-894XPMID 21282055DOI 10.1016/J.BMCL.2011.01.022 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ebp SASH1 solution structure of the sh3 domain from human sam and sh3 domain containing protein 1 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM HUMANTITL 2 SAM AND SH3 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bkw ZFYVE9 crystal structure of the c-terminal region of human zfyve9 2.53Å AUTH E.WILLIAMSTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMAN ZFYVE9REF PH D THESIS 2013PUBL NULL: UNIVERSITY OF OXFORD (THESIS) Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bh7 RP2 crystal structure of the rp2-arl3 complex bound to gdp-alf4 1.9Å AUTH S.VELTEL,R.GASPER,E.EISENACHER,A.WITTINGHOFERTITL THE RETINITIS PIGMENTOSA 2 GENE PRODUCT IS ATITL 2 GTPASE-ACTIVATING PROTEIN FOR ARF-LIKE 3REF NAT.STRUCT.MOL.BIOL. V. 15 373 2008REFN ISSN 1545-9993PMID 18376416DOI 10.1038/NSMB.1396 Variant Set Distributions Mapped Variants
General Structure Information 3fm0 CIAO1 crystal structure of wd40 protein ciao1 1.7Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants