Assessment of Structural Intolerance and Durability
General Structure Information 1cqt POU2F1 crystal structure of a ternary complex containing an oca-b peptide, the oct-1 pou domain, and an octamer element 3.2Å AUTH D.CHASMAN,K.CEPEK,P.A.SHARP,C.O.PABOTITL CRYSTAL STRUCTURE OF AN OCA-B PEPTIDE BOUND TO ANTITL 2 OCT-1 POU DOMAIN/OCTAMER DNA COMPLEX: SPECIFICTITL 3 RECOGNITION OF A PROTEIN-DNA INTERFACE.REF GENES DEV. V. 13 2650 1999REFN ISSN […]
General Structure Information 1avf PGC activation intermediate 2 of human gastricsin from human stomach 2.36Å AUTH A.R.KHAN,M.M.CHERNEY,N.I.TARASOVA,M.N.JAMESTITL STRUCTURAL CHARACTERIZATION OF ACTIVATIONTITL 2 INTERMEDIATE 2 ON THE PATHWAY TO HUMANTITL 3 GASTRICSIN.REF NAT.STRUCT.BIOL. V. 4 1010 1997REFN ISSN 1072-8368PMID 9406551DOI 10.1038/NSB1297-1010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gdz HPGD crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with nad+ 1.65Å AUTH F.H.NIESEN,L.SCHULTZ,A.JADHAV,C.BHATIA,K.GUO,D.J.MALONEY,AUTH 2 E.S.PILKA,M.WANG,U.OPPERMANN,T.D.HEIGHTMAN,A.SIMEONOVTITL HIGH-AFFINITY INHIBITORS OF HUMAN NAD-DEPENDENTTITL 2 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE: MECHANISMS OFTITL 3 INHIBITION AND STRUCTURE-ACTIVITY RELATIONSHIPS.REF PLOS ONE V. 5 E1371 2010REFN ESSN 1932-6203PMID 21072165DOI 10.1371/JOURNAL.PONE.0013719 Variant Set Distributions Mapped Variants
General Structure Information 4dvq CYP11B2 structure of human aldosterone synthase, cyp11b2, in complex with deoxycorticosterone 2.49Å AUTH N.STRUSHKEVICH,A.A.GILEP,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 S.A.USANOV,H.W.PARKTITL STRUCTURAL INSIGHTS INTO ALDOSTERONE SYNTHASE SUBSTRATETITL 2 SPECIFICITY AND TARGETED INHIBITION.REF MOL.ENDOCRINOL. V. 27 315 2013REFN ISSN 0888-8809PMID 23322723DOI 10.1210/ME.2012-1287 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qu6 EIF2AK2 structure of the double-stranded rna-binding domain of the protein kinase pkr reveals the molecular basis of its dsrna-mediated activation -1.0Å AUTH S.NANDURI,B.W.CARPICK,Y.YANG,B.R.WILLIAMS,J.QINTITL STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN OF THE PROTEIN KINASE PKR REVEALS THETITL 3 MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION.REF EMBO J. V. 17 5458 1998REFN ISSN […]
General Structure Information 1ilt IL1RN x-ray structure of interleukin-1 receptor antagonist at 2.0 angstroms resolution 2.0Å AUTH G.P.VIGERS,P.CAFFES,R.J.EVANS,R.C.THOMPSON,AUTH 2 S.P.EISENBERG,B.J.BRANDHUBERTITL X-RAY STRUCTURE OF INTERLEUKIN-1 RECEPTORTITL 2 ANTAGONIST AT 2.0-A RESOLUTION.REF J.BIOL.CHEM. V. 269 12874 1994REFN ISSN 0021-9258PMID 8175703 Variant Set Distributions Mapped Variants
General Structure Information 3owp PRKACA human camp-dependent protein kinase in complex with an inhibitor 1.88Å AUTH H.KOESTER,T.CRAAN,S.BRASS,A.HEINE,G.KLEBETITL FRAGMENT BASED DRUG DESIGN ON PKAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2krr NCL solution structure of the rbd1,2 domains from human nucleolin -1.0Å AUTH S.ARUMUGAM,M.C.MILLER,J.MALIEKAL,P.J.BATES,J.O.TRENT,AUTH 2 A.N.LANETITL SOLUTION STRUCTURE OF THE RBD1,2 DOMAINS FROM HUMANTITL 2 NUCLEOLIN.REF J.BIOMOL.NMR V. 47 79 2010REFN ISSN 0925-2738PMID 20376532DOI 10.1007/S10858-010-9412-1 Variant Set Distributions Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 4fys ANPEP human aminopeptidase n (cd13) in complex with angiotensin iv 2.01Å AUTH A.H.WONG,D.ZHOU,J.M.RINITITL THE X-RAY CRYSTAL STRUCTURE OF HUMAN AMINOPEPTIDASE NTITL 2 REVEALS A NOVEL DIMER AND THE BASIS FOR PEPTIDE PROCESSING.REF J.BIOL.CHEM. V. 287 36804 2012REFN ISSN 0021-9258PMID 22932899DOI 10.1074/JBC.M112.398842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]