Assessment of Structural Intolerance and Durability
General Structure Information 3cxl CHN1 crystal structure of human chimerin 1 (chn1) 2.6Å AUTH L.SHEN,M.BUCK,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN CHIMERIN 1 (CHN1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ri4 ETS1 ets1 cooperative binding to widely separated sites on promoter dna 3.0Å AUTH N.D.BABAYEVA,O.I.BARANOVSKAYA,T.H.TAHIROVTITL STRUCTURAL BASIS OF ETS1 COOPERATIVE BINDING TO WIDELYTITL 2 SEPARATED SITES ON PROMOTER DNA.REF PLOS ONE V. 7 33698 2012REFN ESSN 1932-6203PMID 22432043DOI 10.1371/JOURNAL.PONE.0033698 Variant Set Distributions Mapped Variants
General Structure Information 3k77 XRCC1 x-ray crystal structure of xrcc1 2.6Å AUTH M.J.CUNEO,R.E.LONDONTITL OXIDATION STATE OF THE XRCC1 N-TERMINAL DOMAIN REGULATESTITL 2 DNA POLYMERASE BETA BINDING AFFINITY.REF PROC.NATL.ACAD.SCI.USA V. 107 6805 2010REFN ISSN 0027-8424PMID 20351257DOI 10.1073/PNAS.0914077107 Variant Set Distributions Mapped Variants
General Structure Information 2acu AKR1B1 tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and the crystal structure of the y48h mutant enzyme 1.76Å AUTH K.M.BOHREN,C.E.GRIMSHAW,C.J.LAI,D.H.HARRISON,AUTH 2 D.RINGE,G.A.PETSKO,K.H.GABBAYTITL TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110TITL 2 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY INTITL 3 THE […]
General Structure Information 3ebm TPT1 crystal structure of human translationally controlled tumour associated protein (htctp) mutant e12v 2.6Å AUTH X.DONG,B.YANG,Y.LI,C.ZHONG,J.DINGTITL MOLECULAR BASIS OF THE ACCELERATION OF THE GDP-GTPTITL 2 EXCHANGE OF HUMAN RAS HOMOLOG ENRICHED IN BRAIN BYTITL 3 HUMAN TRANSLATIONALLY CONTROLLED TUMOR PROTEIN.REF J.BIOL.CHEM. V. 284 23754 2009REFN ISSN 0021-9258PMID 19570981DOI 10.1074/JBC.M109.012823 Variant Set […]
General Structure Information 4ern ERCC3 crystal structure of the c-terminal domain of human xpb/ercc-3 excision repair protein at 1.80 a 1.8Å AUTH E.HILARIO,Y.LI,Y.NOBUMORI,X.LIU,L.FANTITL STRUCTURE OF THE C-TERMINAL HALF OF HUMAN XPB HELICASE ANDTITL 2 THE IMPACT OF THE DISEASE-CAUSING MUTATION XP11BE.REF ACTA CRYSTALLOGR.,SECT.D V. 69 237 2013REFN ISSN 0907-4449PMID 23385459DOI 10.1107/S0907444912045040 Variant Set Distributions Ripley’s […]
General Structure Information 1yfk PGAM1 crystal structure of human b type phosphoglycerate mutase 2.7Å AUTH Y.WANG,Z.WEI,L.LIU,Z.CHENG,Y.LIN,F.JI,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN B-TYPE PHOSPHOGLYCERATETITL 2 MUTASE BOUND WITH CITRATE.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 331 1207 2005REFN ISSN 0006-291XPMID 15883004DOI 10.1016/J.BBRC.2005.03.243 Variant Set Distributions Mapped Variants
General Structure Information 3thc GLB1 crystal structure of human beta-galactosidase in complex with galactose 1.8Å AUTH U.OHTO,K.USUI,T.OCHI,K.YUKI,Y.SATOW,T.SHIMIZUTITL CRYSTAL STRUCTURE OF HUMAN BETA-GALACTOSIDASE: STRUCTURALTITL 2 BASIS OF GM1 GANGLIOSIDOSIS AND MORQUIO B DISEASESREF J.BIOL.CHEM. V. 287 1801 2012REFN ISSN 0021-9258PMID 22128166DOI 10.1074/JBC.M111.293795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2vo1 CTPS1 crystal structure of the synthetase domain of human ctp synthetase 2.8Å AUTH P.KURSULA,S.FLODIN,M.EHN,M.HAMMARSTROM,H.SCHULER,P.NORDLUND,AUTH 2 P.STENMARKTITL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE,TITL 2 A TARGET FOR ANTICANCER THERAPY.REF ACTA CRYSTALLOGR.,SECT.F V. 62 613 2006REFN ISSN 1744-3091PMID 16820675DOI 10.1107/S1744309106018136 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qfc POR crystal structure of human nadph-cytochrome p450 (v492e mutant) 1.8Å AUTH C.XIA,S.P.PANDA,C.C.MAROHNIC,P.MARTASEK,B.S.MASTERS,J.J.KIMTITL STRUCTURAL BASIS FOR HUMAN NADPH-CYTOCHROME P450TITL 2 OXIDOREDUCTASE DEFICIENCY.REF PROC.NATL.ACAD.SCI.USA V. 108 13486 2011REFN ISSN 0027-8424PMID 21808038DOI 10.1073/PNAS.1106632108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants