Assessment of Structural Intolerance and Durability
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3thx MSH3 human mutsbeta complexed with an idl of 3 bases (loop3) and adp 2.7Å AUTH S.GUPTA,M.GELLERT,W.YANGTITL MECHANISM OF MISMATCH RECOGNITION REVEALED BY HUMAN MUTSBETATITL 2 BOUND TO UNPAIRED DNA LOOPSREF NAT.STRUCT.MOL.BIOL. V. 19 72 2012REFN ISSN 1545-9993PMID 22179786DOI 10.1038/NSMB.2175 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2b9r CCNB1 crystal structure of human cyclin b1 2.9Å AUTH E.T.PETRI,A.ERRICO,L.ESCOBEDO,T.HUNT,R.BASAVAPPATITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN B.REF CELL CYCLE V. 6 1342 2007REFN ISSN 1538-4101PMID 17495533 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1aoa PLS3 n-terminal actin-crosslinking domain from human fimbrin 2.4Å AUTH S.C.GOLDSMITH,N.POKALA,W.SHEN,A.A.FEDOROV,AUTH 2 P.MATSUDAIRA,S.C.ALMOTITL THE STRUCTURE OF AN ACTIN-CROSSLINKING DOMAIN FROMTITL 2 HUMAN FIMBRIN.REF NAT.STRUCT.BIOL. V. 4 708 1997REFN ISSN 1072-8368PMID 9302997DOI 10.1038/NSB0997-708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hnx FABP4 crystal structure of ap2 1.5Å AUTH E.MARR,M.TARDIE,M.CARTY,T.BROWN PHILLIPS,I.K.WANG,AUTH 2 W.SOELLER,X.QIU,G.KARAMTITL EXPRESSION, PURIFICATION, CRYSTALLIZATION ANDTITL 2 STRUCTURE OF HUMAN ADIPOCYTE LIPID-BINDING PROTEINTITL 3 (AP2).REF ACTA CRYSTALLOGR.,SECT.F V. 62 1058 2006REFN ESSN 1744-3091PMID 17077479DOI 10.1107/S1744309106038656 Variant Set Distributions Mapped Variants
General Structure Information 3di2 IL7R crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3di2 IL7 crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain 2.7Å AUTH C.A.MCELROY,J.A.DOHM,S.T.WALSHTITL STRUCTURAL AND BIOPHYSICAL STUDIES OF THE HUMANTITL 2 IL-7/IL-7RALPHA COMPLEX.REF STRUCTURE V. 17 54 2009REFN ISSN 0969-2126PMID 19141282DOI 10.1016/J.STR.2008.10.019 Variant Set Distributions Mapped Variants
General Structure Information 3fe2 DDX5 human dead-box rna helicase ddx5 (p68), conserved domain i in complex with adp 2.6Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASESREF PLOS ONE V. 5 E1279 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 1nd5 ACPP crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design 2.9Å AUTH E.ORTLUND,M.W.LACOUNT,L.LEBIODATITL CRYSTAL STRUCTURES OF HUMAN PROSTATIC ACID PHOSPHATASE INTITL 2 COMPLEX WITH A PHOSPHATE ION ANDTITL 3 ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID UPDATE THETITL […]
General Structure Information 4fpa HK1 crystal structure of recombinant human hexokinase type i mutant d413n glucose 6-phosphate 2.48Å AUTH L.SHEN,Y.GAO,R.B.HONZATKOTITL DETERMINATION OF SITE AFFINITY CONSTANTS FOR PRODUCTTITL 2 INHIBITION OF WILD-TYPE AND MUTANT FORMS OF RECOMBINANTTITL 3 HUMAN HEXOKINASE TYPE IREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]