Assessment of Structural Intolerance and Durability
General Structure Information 3es6 PIP crystal structure of the novel complex formed between zinc 2- glycoprotein (zag) and prolactin inducible protein (pip) from human seminal plasma 3.23Å AUTH M.I.HASSAN,S.BILGRAMI,V.KUMAR,N.SINGH,S.YADAV,P.KAUR,AUTH 2 T.P.SINGHTITL CRYSTAL STRUCTURE OF THE NOVEL COMPLEX FORMED BETWEEN ZINCTITL 2 ALPHA2-GLYCOPROTEIN (ZAG) AND PROLACTIN-INDUCIBLE PROTEINTITL 3 (PIP) FROM HUMAN SEMINAL PLASMAREF J.MOL.BIOL. V. 384 […]
General Structure Information 2oo0 ODC1 a structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane 1.9Å AUTH V.T.DUFE,D.INGNER,O.HEBY,A.R.KHOMUTOV,L.PERSSON,AUTH 2 S.AL-KARADAGHITITL A STRUCTURAL INSIGHT INTO THE INHIBITION OF HUMAN ANDTITL 2 LEISHMANIA DONOVANI ORNITHINE DECARBOXYLASES BYTITL 3 1-AMINO-OXY-3-AMINOPROPANE.REF BIOCHEM.J. V. 405 261 2007REFN ISSN 0264-6021PMID 17407445DOI 10.1042/BJ20070188 Variant Set Distributions Ripley’s […]
General Structure Information 3cxe CSF2RA structure of the gm-csf receptor complex 3.3Å AUTH G.HANSEN,T.R.HERCUS,B.J.MCCLURE,F.C.STOMSKI,M.DOTTORE,AUTH 2 J.POWELL,H.RAMSHAW,J.M.WOODCOCK,Y.XU,M.GUTHRIDGE,AUTH 3 W.J.MCKINSTRY,A.F.LOPEZ,M.W.PARKERTITL THE STRUCTURE OF THE GM-CSF RECEPTOR COMPLEX REVEALS ATITL 2 DISTINCT MODE OF CYTOKINE RECEPTOR ACTIVATIONREF CELL(CAMBRIDGE,MASS.) V. 134 496 2008REFN ISSN 0092-8674PMID 18692472DOI 10.1016/J.CELL.2008.05.053 Variant Set Distributions Mapped Variants
General Structure Information 1l8k PTPN2 t cell protein-tyrosine phosphatase structure 2.56Å AUTH L.F.IVERSEN,K.B.MOLLER,A.K.PEDERSEN,G.H.PETERS,AUTH 2 A.S.PETERSEN,H.S.ANDERSEN,S.BRANNER,S.B.MORTENSEN,AUTH 3 N.P.MOLLERTITL STRUCTURE DETERMINATION OF T CELL PROTEIN-TYROSINETITL 2 PHOSPHATASE.REF J.BIOL.CHEM. V. 277 19982 2002REFN ISSN 0021-9258PMID 11907034DOI 10.1074/JBC.M200567200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4nh9 HSP90B1 correlation between chemotype-dependent binding conformations of hsp90 alpha/beta and isoform selectivity 2.77Å AUTH J.T.ERNST,M.LIU,H.ZUCCOLA,T.NEUBERT,K.BEAUMONT,A.TURNBULL,AUTH 2 A.KALLEL,B.VOUGHT,D.STAMOSTITL CORRELATION BETWEEN CHEMOTYPE-DEPENDENT BINDINGTITL 2 CONFORMATIONS OF HSP90 ALPHA / BETA AND ISOFORMTITL 3 SELECTIVITY-IMPLICATIONS FOR THE STRUCTURE-BASED DESIGN OFTITL 4 HSP90 ALPHA / BETA SELECTIVE INHIBITORS FOR TREATINGTITL 5 NEURODEGENERATIVE DISEASES.REF BIOORG.MED.CHEM.LETT. V. […]
General Structure Information 1n6k RAB5A crystal structure of human rab5a a30p mutant complex with gdp and aluminum fluoride 1.55Å AUTH G.ZHU,J.LIU,S.TERZYAN,P.ZHAI,G.LI,X.C.ZHANGTITL HIGH RESOLUTION CRYSTAL STRUCTURES OF HUMAN RAB5ATITL 2 AND FIVE MUTANTS WITH SUBSTITUTIONS IN THETITL 3 CATALYTICALLY IMPORTANT PHOSPHATE-BINDING LOOPREF J.BIOL.CHEM. V. 278 2452 2003REFN ISSN 0021-9258PMID 12433916DOI 10.1074/JBC.M211042200 Variant Set Distributions Ripley’s K […]
General Structure Information 4fxf PKM structure of m2 pyruvate kinase in complex with phenylalanine 2.55Å AUTH H.P.MORGAN,F.J.OREILLY,M.A.WEAR,J.R.ONEILL,AUTH 2 L.A.FOTHERGILL-GILMORE,T.HUPP,M.D.WALKINSHAWTITL M2 PYRUVATE KINASE PROVIDES A MECHANISM FOR NUTRIENT SENSINGTITL 2 AND REGULATION OF CELL PROLIFERATION.REF PROC.NATL.ACAD.SCI.USA V. 110 5881 2013REFN ISSN 0027-8424PMID 23530218DOI 10.1073/PNAS.1217157110 Variant Set Distributions Mapped Variants
General Structure Information 1bp1 BPI crystal structure of bpi, the human bactericidal permeability-increasing protein 2.4Å AUTH L.J.BEAMER,S.F.CARROLL,D.EISENBERGTITL CRYSTAL STRUCTURE OF HUMAN BPI AND TWO BOUNDTITL 2 PHOSPHOLIPIDS AT 2.4 ANGSTROM RESOLUTION.REF SCIENCE V. 276 1861 1997REFN ISSN 0036-8075PMID 9188532DOI 10.1126/SCIENCE.276.5320.1861 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d8m XRCC1 solution structure of the first brct domain of dna-repair protein xrcc1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST BRCT DOMAIN OFTITL 2 DNA-REPAIR PROTEIN XRCC1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uuh CD44 hyaluronan binding domain of human cd44 2.2Å AUTH P.TERIETE,S.BANERJI,M.NOBLE,C.BLUNDELL,A.WRIGHT,AUTH 2 A.PICKFORD,E.LOWE,D.MAHONEY,M.TAMMI,J.KAHMANN,AUTH 3 I.CAMPBELL,A.DAY,D.JACKSONTITL STRUCTURE OF THE REGULATORY HYALURONAN-BINDINGTITL 2 DOMAIN IN THE INFLAMMATORY LEUKOCYTE HOMINGTITL 3 RECEPTOR CD44REF MOL.CELL V. 13 483 2004REFN ISSN 1097-2765PMID 14992719DOI 10.1016/S1097-2765(04)00080-2 Variant Set Distributions Mapped Variants