4NH9.A | HSP90B1

General Structure Information

PDB ID 4nh9
HGNC Gene Label(s) HSP90B1
Structure Name correlation between chemotype-dependent binding conformations of hsp90 alpha/beta and isoform selectivity
Resolution 2.77Å
Reference AUTH J.T.ERNST,M.LIU,H.ZUCCOLA,T.NEUBERT,K.BEAUMONT,A.TURNBULL,AUTH 2 A.KALLEL,B.VOUGHT,D.STAMOSTITL CORRELATION BETWEEN CHEMOTYPE-DEPENDENT BINDINGTITL 2 CONFORMATIONS OF HSP90 ALPHA / BETA AND ISOFORMTITL 3 SELECTIVITY-IMPLICATIONS FOR THE STRUCTURE-BASED DESIGN OFTITL 4 HSP90 ALPHA / BETA SELECTIVE INHIBITORS FOR TREATINGTITL 5 NEURODEGENERATIVE DISEASES.REF BIOORG.MED.CHEM.LETT. V. 24 204 2014REFN ISSN 0960-894XPMID 24332488DOI 10.1016/J.BMCL.2013.11.036

Variant Set Distributions

ExAC Variants

Number Of Residues 214
Number Of SNVs 37
Number Of Permutations 20081
Optimal Distance Threshold 7.0
K Statistic 0.042
p-value 0.623

Mapped Variants

[+] ExAC Missense Variants