Assessment of Structural Intolerance and Durability
General Structure Information 1j1d TNNI3 crystal structure of the 46kda domain of human cardiac troponin in the ca2+ saturated form 2.61Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zmm DEFA4 crystal structure of human alpha-defensin-4 1.6Å AUTH A.SZYK,Z.WU,K.TUCKER,D.YANG,W.LU,J.LUBKOWSKITITL CRYSTAL STRUCTURES OF HUMAN {ALPHA}-DEFENSINS HNP4, HD5, ANDTITL 2 HD6.REF PROTEIN SCI. V. 15 2749 2006REFN ISSN 0961-8368PMID 17088326DOI 10.1110/PS.062336606 Variant Set Distributions Mapped Variants
General Structure Information 1nfb IMPDH2 ternary complex of the human type ii inosine monophosphate dedhydrogenase with 6cl-imp and nad 2.9Å AUTH D.RISAL,M.D.STRICKLER,B.M.GOLDSTEINTITL THE CONFORMATION OF NAD BOUND TO HUMAN INOSINE MONOPHOSPHATETITL 2 DEHYDROGENASE TYPE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ni2 EZR structure of the active ferm domain of ezrin 2.3Å AUTH W.J.SMITH,N.NASSAR,A.P.BRETSCHER,R.A.CERIONE,AUTH 2 P.A.KARPLUSTITL STRUCTURE OF THE ACTIVE N-TERMINAL DOMAIN OFTITL 2 EZRIN. CONFORMATIONAL AND MOBILITY CHANGESTITL 3 IDENTIFY KEYSTONE INTERACTIONS.REF J.BIOL.CHEM. V. 278 4949 2003REFN ISSN 0021-9258PMID 12429733DOI 10.1074/JBC.M210601200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3d3l ALOX12 the 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type (casp target) 2.6Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,K.OLESEN,C.PERSSON,J.SAGEMARK,H.SCHUELER,AUTH 7 L.SVENSSON,A.G.THORSELL,S.VAN DEN BERG,M.WELIN,AUTH 8 J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE LIPOXYGENASE DOMAIN OFTITL 2 HUMAN ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE.REF TO BE PUBLISHEDREFN […]
General Structure Information 1l8z UBTF solution structure of hmg box 5 in human upstream binding factor -1.0Å AUTH W.YANG,Y.XU,J.WU,W.ZENG,Y.SHITITL SOLUTION STRUCTURE AND DNA BINDING PROPERTY OF THETITL 2 FIFTH HMG BOX DOMAIN IN COMPARISON WITH THE FIRSTTITL 3 HMG BOX DOMAIN IN HUMAN UPSTREAM BINDING FACTORREF BIOCHEMISTRY V. 42 1930 2003REFN ISSN 0006-2960PMID 12590579DOI 10.1021/BI026372X […]
General Structure Information 3r27 HNRNPL crystal structure of the first rrm domain of heterogeneous nuclear ribonucleoprotein l (hnrnp l) 2.04Å AUTH W.ZHANG,Y.LIU,F.ZENG,L.NIU,M.TENG,X.LITITL CRYSTAL STRUCTURE OF THE FIRST RRM DOMAIN OF HETEROGENEOUSTITL 2 NUCLEAR RIBONUCLEOPROTEIN L (HNRNP L)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1k99 UBTF solution structure of the first hmg box in human upstream binding factor -1.0Å AUTH Y.XU,W.YANG,J.WU,Y.SHITITL SOLUTION STRUCTURE OF THE FIRST HMG BOX DOMAIN INTITL 2 HUMAN UPSTREAM BINDING FACTOR.REF BIOCHEMISTRY V. 41 5415 2002REFN ISSN 0006-2960PMID 11969401DOI 10.1021/BI015977A Variant Set Distributions Mapped Variants
General Structure Information 3h6a ITGB4 structure of the calx-beta domain of integrin beta4 crystallized in the presence of calcium 1.61Å AUTH N.ALONSO-GARCIA,A.INGLES-PRIETO,A.SONNENBERG,AUTH 2 J.M.DE PEREDATITL STRUCTURE OF THE CALX-BETA DOMAIN OF THE INTEGRINTITL 2 BETA4 SUBUNIT: INSIGHTS INTO FUNCTION ANDTITL 3 CATION-INDEPENDENT STABILITYREF ACTA CRYSTALLOGR.,SECT.D V. 65 858 2009REFN ISSN 0907-4449PMID 19622870DOI 10.1107/S0907444909018745 Variant Set […]
General Structure Information 2cub NCK1 solution structure of the sh3 domain of the human cytoplasmic protein nck1 -1.0Å AUTH S.OHNISHI,T.KIGAWA,M.SATO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF THE HUMANTITL 2 CYTOPLASMIC PROTEIN NCK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants