Assessment of Structural Intolerance and Durability
General Structure Information 2qc7 ERP29 crystal structure of the protein-disulfide isomerase related chaperone erp29 2.9Å AUTH N.N.BARAK,P.NEUMANN,M.SEVVANA,M.SCHUTKOWSKI,K.NAUMANN,AUTH 2 M.MALESEVIC,H.REICHARDT,G.FISCHER,M.T.STUBBS,D.M.FERRARITITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN ERP29.REF J.MOL.BIOL. V. 385 1630 2009REFN ISSN 0022-2836PMID 19084538DOI 10.1016/J.JMB.2008.11.052 Variant Set Distributions Mapped Variants
General Structure Information 1nn6 CMA1 human pro-chymase 1.75Å AUTH K.K.REILING,J.KRUCINSKI,L.J.MIERCKE,W.W.RAYMOND,G.H.CAUGHEY,AUTH 2 R.M.STROUDTITL STRUCTURE OF HUMAN PRO-CHYMASE: A MODEL FOR THE ACTIVATINGTITL 2 TRANSITION OF GRANULE-ASSOCIATED PROTEASES.REF BIOCHEMISTRY V. 42 2616 2003REFN ISSN 0006-2960PMID 12614156DOI 10.1021/BI020594D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1l9l GNLY granulysin from human cytolytic t lymphocytes 0.92Å AUTH D.H.ANDERSON,M.R.SAWAYA,D.CASCIO,W.ERNST,R.MODLIN,AUTH 2 A.KRENSKY,D.EISENBERGTITL GRANULYSIN CRYSTAL STRUCTURE AND ATITL 2 STRUCTURE-DERIVED LYTIC MECHANISMREF J.MOL.BIOL. V. 325 355 2002REFN ISSN 0022-2836PMID 12488100DOI 10.1016/S0022-2836(02)01234-2 Variant Set Distributions Mapped Variants
General Structure Information 1bnd BDNF structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer 2.3Å AUTH R.C.ROBINSON,C.RADZIEJEWSKI,D.I.STUART,E.Y.JONESTITL STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHICTITL 2 FACTOR/NEUROTROPHIN 3 HETERODIMER.REF BIOCHEMISTRY V. 34 4139 1995REFN ISSN 0006-2960PMID 7703225DOI 10.1021/BI00013A001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fss RASA1 crystal structure of a ras p21 protein activator (rasa1) from homo sapiens at 2.25 a resolution 2.25Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A RAS P21 PROTEIN ACTIVATOR (RASA1)TITL 2 FROM HOMO SAPIENS AT 2.25 A RESOLUTIONREF TO BE PUBLISHEDREFN […]
General Structure Information 3gtu GSTM3 ligand-free heterodimeric human glutathione s-transferase m2-3 (ec 2.5.1.18), monoclinic crystal form 2.8Å AUTH Y.V.PATSKOVSKY,L.N.PATSKOVSKA,I.LISTOWSKYTITL AN ASPARAGINE-PHENYLALANINE SUBSTITUTION ACCOUNTSTITL 2 FOR CATALYTIC DIFFERENCES BETWEEN HGSTM3-3 ANDTITL 3 OTHER HUMAN CLASS MU GLUTATHIONE S-TRANSFERASES.REF BIOCHEMISTRY V. 38 16187 1999REFN ISSN 0006-2960PMID 10587441DOI 10.1021/BI991714T Variant Set Distributions Mapped Variants
General Structure Information 2uur COL9A1 n-terminal nc4 domain of collagen ix 1.8Å AUTH V.-M.LEPPANEN,H.TOSSAVAINEN,P.PERMI,L.LEHTIO,AUTH 2 G.RONNHOLM,A.GOLDMAN,I.KILPELAINEN,T.PIHLAJAMAATITL CRYSTAL STRUCTURE OF THE N-TERMINAL NC4 DOMAIN OFTITL 2 COLLAGEN IX, A ZINC BINDING MEMBER OF THE LAMININ-TITL 3 NEUREXIN-SEX HORMONE BINDING GLOBULIN (LNS) DOMAINTITL 4 FAMILY.REF J.BIOL.CHEM. V. 282 23219 2007REFN ISSN 0021-9258PMID 17553797DOI 10.1074/JBC.M702514200 Variant Set Distributions […]
General Structure Information 3fe4 CA6 crystal structure of human carbonic anhydrase vi 1.9Å AUTH E.S.PILKA,G.KOCHAN,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF THE SECRETORY ISOZYME OF MAMMALIANTITL 2 CARBONIC ANHYDRASES CA VI: IMPLICATIONS FOR BIOLOGICALTITL 3 ASSEMBLY AND INHIBITOR DEVELOPMENTREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 419 485 2012REFN ISSN 0006-291XPMID 22366092DOI 10.1016/J.BBRC.2012.02.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4nnr FKBP2 fkbp13-fk506 complex 1.98Å AUTH L.W.SCHULTZ,P.K.MARTIN,J.LIANG,S.L.SCHREIBER,J.CLARDYTITL ATOMIC STRUCTURE OF THE IMMUNOPHILIN FKBP13-FK506 COMPLEX:TITL 2 INSIGHTS INTO THE COMPOSITE BINDING SURFACE FOR CALCINEURINREF J.AM.CHEM.SOC. V. 116 3129 1994REFN ISSN 0002-7863DOI 10.1021/JA00086A055 Variant Set Distributions Mapped Variants
General Structure Information 1m5i APC crystal structure of the coiled coil region 129-250 of the tumor suppressor gene product apc 2.0Å AUTH L.TICKENBROCK,J.CRAMER,I.R.VETTER,O.MULLERTITL THE COILED COIL REGION (AMINO ACIDS 129-250) OFTITL 2 THE TUMOR SUPPRESSOR PROTEIN ADENOMATOUS POLYPOSISTITL 3 COLI (APC). ITS STRUCTURE AND ITS INTERACTION WITHTITL 4 CHROMOSOME MAINTENANCE REGION 1 (CRM-1).REF J.BIOL.CHEM. V. […]