Assessment of Structural Intolerance and Durability
General Structure Information 2j1k CXADR cav-2 fibre head in complex with car d1 2.3Å AUTH E.SEIRADAKE,H.LORTAT-JACOB,O.BILLET,E.J.KREMER,S.CUSACKTITL STRUCTURAL AND MUTATIONAL ANALYSIS OF HUMAN AD37 AND CANINETITL 2 ADENOVIRUS 2 FIBER HEADS IN COMPLEX WITH THE D1 DOMAIN OFTITL 3 COXSACKIE AND ADENOVIRUS RECEPTOR.REF J.BIOL.CHEM. V. 281 33704 2006REFN ISSN 0021-9258PMID 16923808DOI 10.1074/JBC.M605316200 Variant Set Distributions Mapped […]
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 2wno TNFAIP6 x-ray structure of cub_c domain from tsg-6 2.3Å AUTH D.C.BRIGGS,H.L.BIRCHENOUGH,T.ALI,M.S.RUGG,J.P.WALTHO,AUTH 2 E.IEVOLI,T.A.JOWITT,J.J.ENGHILD,R.P.RICHTER,A.SALUSTRI,AUTH 3 C.M.MILNER,A.J.DAYTITL METAL ION-DEPENDENT HEAVY CHAIN TRANSFER ACTIVITY OF TSG-6TITL 2 MEDIATES ASSEMBLY OF THE CUMULUS-OOCYTE MATRIXREF J.BIOL.CHEM. 2015REFN ESSN 1083-351XPMID 26468290DOI 10.1074/JBC.M115.669838 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i6a ADK human adenosine kinase in complex with 5-deoxy-5- iodotubercidin 2.2Å AUTH S.W.MUCHMORE,R.A.SMITH,A.O.STEWART,M.D.COWART,AUTH 2 A.GOMTSYAN,M.A.MATULENKO,H.YU,J.M.SEVERIN,AUTH 3 S.S.BHAGWAT,C.H.LEE,E.A.KOWALUK,M.F.JARVIS,AUTH 4 C.L.JAKOBTITL CRYSTAL STRUCTURES OF HUMAN ADENOSINE KINASETITL 2 INHIBITOR COMPLEXES REVEAL TWO DISTINCT BINDINGTITL 3 MODES.REF J.MED.CHEM. V. 49 6726 2006REFN ISSN 0022-2623PMID 17154503DOI 10.1021/JM060189A Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1d5r PTEN crystal structure of the pten tumor suppressor 2.1Å AUTH J.O.LEE,H.YANG,M.M.GEORGESCU,A.DI CRISTOFANO,AUTH 2 T.MAEHAMA,Y.SHI,J.E.DIXON,P.PANDOLFI,N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR:TITL 2 IMPLICATIONS FOR ITS PHOSPHOINOSITIDE PHOSPHATASETITL 3 ACTIVITY AND MEMBRANE ASSOCIATION.REF CELL(CAMBRIDGE,MASS.) V. 99 323 1999REFN ISSN 0092-8674PMID 10555148DOI 10.1016/S0092-8674(00)81663-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3q7q RRAD crystal structure of rad g-domain q148a-gtp analog complex 2.3Å AUTH Y.SASSON,L.NAVON-PERRY,D.HUPPERT,J.A.HIRSCHTITL RGK FAMILY G-DOMAIN:GTP ANALOG COMPLEX STRUCTURES ANDTITL 2 NUCLEOTIDE-BINDING PROPERTIES.REF J.MOL.BIOL. V. 413 372 2011REFN ISSN 0022-2836PMID 21903096DOI 10.1016/J.JMB.2011.08.017 Variant Set Distributions Mapped Variants
General Structure Information 2p6b PPP3R1 crystal structure of human calcineurin in complex with pvivit peptide 2.3Å AUTH H.LI,L.ZHANG,A.RAO,S.C.HARRISON,P.G.HOGANTITL STRUCTURE OF CALCINEURIN IN COMPLEX WITH PVIVITTITL 2 PEPTIDE: PORTRAIT OF A LOW-AFFINITY SIGNALLINGTITL 3 INTERACTIONREF J.MOL.BIOL. V. 369 1296 2007REFN ISSN 0022-2836PMID 17498738DOI 10.1016/J.JMB.2007.04.032 Variant Set Distributions Mapped Variants
General Structure Information 1yx6 PSMD4 solution structure of s5a uim-2/ubiquitin complex -1.0Å AUTH Q.WANG,P.YOUNG,K.J.WALTERSTITL STRUCTURE OF S5A BOUND TO MONOUBIQUITIN PROVIDES ATITL 2 MODEL FOR POLYUBIQUITIN RECOGNITIONREF J.MOL.BIOL. V. 348 727 2005REFN ISSN 0022-2836PMID 15826667DOI 10.1016/J.JMB.2005.03.007 Variant Set Distributions Mapped Variants
General Structure Information 2x7g SRPK2 structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b 2.5Å AUTH A.C.W.PIKE,P.SAVITSKY,O.FEDOROV,T.KROJER,E.UGOCHUKWU,AUTH 2 F.VON DELFT,O.GILEADI,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN- SPECIFICTITL 2 KINASE 2 (SRPK2) BOUND TO PURVALANOL BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3phd UBA52 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants