Assessment of Structural Intolerance and Durability
General Structure Information 1x0f HNRNPD complex structure of the c-terminal rna-binding domain of hnrnp d(auf1) with telomeric dna -1.0Å AUTH Y.ENOKIZONO,Y.KONISHI,K.NAGATA,K.OUHASHI,S.UESUGI,AUTH 2 F.ISHIKAWA,M.KATAHIRATITL STRUCTURE OF HNRNP D COMPLEXED WITHTITL 2 SINGLE-STRANDED TELOMERE DNA AND UNFOLDING OF THETITL 3 QUADRUPLEX BY HETEROGENEOUS NUCLEARTITL 4 RIBONUCLEOPROTEIN D.REF J.BIOL.CHEM. V. 280 18862 2005REFN ISSN 0021-9258PMID 15734733DOI 10.1074/JBC.M411822200 Variant […]
General Structure Information 3sea RHEB structure of rheb-y35a mutant in gdp- and gmppnp-bound forms 2.0Å AUTH M.T.MAZHAB-JAFARI,C.B.MARSHALL,N.ISHIYAMA,J.HO,V.DI PALMA,AUTH 2 V.STAMBOLIC,M.IKURATITL AN AUTOINHIBITED NONCANONICAL MECHANISM OF GTP HYDROLYSIS BYTITL 2 RHEB MAINTAINS MTORC1 HOMEOSTASIS.REF STRUCTURE V. 20 1528 2012REFN ISSN 0969-2126PMID 22819219DOI 10.1016/J.STR.2012.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2d8z FHL2 solution structure of the third lim domain of four and a half lim domains protein 2 (fhl-2) -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD LIM DOMAIN OF FOURTITL 2 AND A HALF LIM DOMAINS PROTEIN 2 (FHL-2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4erv RYR3 crystal structure of human ryanodine receptor 3 (2597-2800) 1.75Å AUTH Z.YUCHI,K.LAU,F.VAN PETEGEMTITL DISEASE MUTATIONS IN THE RYANODINE RECEPTOR CENTRAL REGION:TITL 2 CRYSTAL STRUCTURES OF A PHOSPHORYLATION HOT SPOT DOMAIN.REF STRUCTURE V. 20 1201 2012REFN ISSN 0969-2126PMID 22705209DOI 10.1016/J.STR.2012.04.015 Variant Set Distributions Mapped Variants
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2mbg RALBP1 rlip76 (gap-gbd) -1.0Å AUTH K.V.RAJASEKAR,L.J.CAMPBELL,D.NIETLISPACH,D.OWEN,H.R.MOTTTITL THE STRUCTURE OF THE RLIP76 RHOGAP-RAL BINDING DOMAIN DYAD:TITL 2 FIXED POSITION OF THE DOMAINS LEADS TO DUAL ENGAGEMENT OFTITL 3 SMALL G PROTEINS AT THE MEMBRANE.REF STRUCTURE V. 21 2131 2013REFN ISSN 0969-2126PMID 24207123DOI 10.1016/J.STR.2013.09.007 Variant Set Distributions Mapped Variants
General Structure Information 4mq2 DYRK1A the crystal structure of dyrk1a with a bound pyrido[2,3-d]pyrimidine inhibitor 2.8Å AUTH K.ANDERSON,Y.CHEN,Z.CHEN,R.DOMINIQUE,K.GLENN,Y.HE,C.JANSON,AUTH 2 K.C.LUK,C.LUKACS,A.POLONSKAIA,Q.QIAO,A.RAILKAR,P.ROSSMAN,AUTH 3 H.SUN,Q.XIANG,M.VILENCHIK,P.WOVKULICH,X.ZHANGTITL PYRIDO[2,3-D]PYRIMIDINES: DISCOVERY AND PRELIMINARY SAR OF ATITL 2 NOVEL SERIES OF DYRK1B AND DYRK1A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 6610 2013REFN ISSN 0960-894XPMID 24239188DOI 10.1016/J.BMCL.2013.10.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]