Assessment of Structural Intolerance and Durability
General Structure Information 1s1c ROCK1 crystal structure of the complex between the human rhoa and rho-binding domain of human rocki 2.6Å AUTH R.DVORSKY,L.BLUMENSTEIN,I.R.VETTER,M.R.AHMADIANTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF ROCKITITL 2 WITH THE SWITCH REGIONS OF RHOA.REF J.BIOL.CHEM. V. 279 7098 2004REFN ISSN 0021-9258PMID 14660612DOI 10.1074/JBC.M311911200 Variant Set Distributions Mapped Variants
General Structure Information 2mf9 FKBP8 solution structure of the n-terminal domain of human fkbp38 (fkbp38ntd) -1.0Å AUTH C.KANG,H.YE,J.CHIA,B.H.CHOI,S.DHE-PAGANON,B.SIMON,U.SCHUTZ,AUTH 2 M.SATTLER,H.S.YOONTITL FUNCTIONAL ROLE OF THE FLEXIBLE N-TERMINAL EXTENSION OFTITL 2 FKBP38 IN CATALYSIS.REF SCI REP V. 3 2985 2013REFN ESSN 2045-2322PMID 24145868DOI 10.1038/SREP02985 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2eho GINS1 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 1cb5 BLMH human bleomycin hydrolase. 2.59Å AUTH P.A.OFARRELL,F.GONZALEZ,W.ZHENG,S.A.JOHNSTON,L.JOSHUA-TORTITL CRYSTAL STRUCTURE OF HUMAN BLEOMYCIN HYDROLASE, ATITL 2 SELF-COMPARTMENTALIZING CYSTEINE PROTEASE.REF STRUCTURE FOLD.DES. V. 7 619 1999REFN ISSN 0969-2126PMID 10404591DOI 10.1016/S0969-2126(99)80083-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ogj PRKG1 crystal structure of partial apo (92-227) of cgmp-dependent protein kinase 2.75Å AUTH J.J.KIM,D.E.CASTEEL,G.HUANG,T.H.KWON,R.K.REN,P.ZWART,AUTH 2 J.J.HEADD,N.G.BROWN,D.C.CHOW,T.PALZKILL,C.KIMTITL CO-CRYSTAL STRUCTURES OF PKG IBETA (92-227) WITH CGMP ANDTITL 2 CAMP REVEAL THE MOLECULAR DETAILS OF CYCLIC-NUCLEOTIDETITL 3 BINDINGREF PLOS ONE V. 6 E1841 2011REFN ESSN 1932-6203PMID 21526164DOI 10.1371/JOURNAL.PONE.0018413 Variant Set Distributions Mapped Variants
General Structure Information 3g4h RGN crystal structure of human senescence marker protein-30 (zinc bound) 1.92Å AUTH S.CHAKRABORTI,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN SENESCENCE MARKER PROTEIN 30:TITL 2 INSIGHTS LINKING STRUCTURAL, ENZYMATIC, AND PHYSIOLOGICALTITL 3 FUNCTIONS .REF BIOCHEMISTRY V. 49 3436 2010REFN ISSN 0006-2960PMID 20329768DOI 10.1021/BI9022297 Variant Set Distributions Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2e7c MYBPC2 solution structure of the 6th ig-like domain from human myosin-binding protein c, fast-type -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 6TH IG-LIKE DOMAIN FROMTITL 2 HUMAN MYOSIN-BINDING PROTEIN C, FAST-TYPEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uap PCOLCE nmr structure of the ntr domain from human pcolce1 -1.0Å AUTH E.LIEPINSH,L.BANYAI,G.PINTACUDA,M.TREXLER,L.PATTHY,AUTH 2 G.OTTINGTITL NMR STRUCTURE OF THE NETRIN-LIKE DOMAIN (NTR) OFTITL 2 HUMAN TYPE I PROCOLLAGEN C-PROTEINASE ENHANCERTITL 3 DEFINES STRUCTURAL CONSENSUS OF NTR DOMAINS ANDTITL 4 ASSESSES POTENTIAL PROTEINASE INHIBITORY ACTIVITYTITL 5 AND LIGAND BINDING.REF J.BIOL.CHEM. V. 278 […]
General Structure Information 1i16 IL16 structure of interleukin 16: implications for function, nmr, 20 structures -1.0Å AUTH P.MUHLHAHN,M.ZWECKSTETTER,J.GEORGESCU,C.CIOSTO,AUTH 2 C.RENNER,M.LANZENDORFER,K.LANG,D.AMBROSIUS,M.BAIER,AUTH 3 R.KURTH,T.A.HOLAKTITL STRUCTURE OF INTERLEUKIN 16 RESEMBLES A PDZ DOMAINTITL 2 WITH AN OCCLUDED PEPTIDE BINDING SITE.REF NAT.STRUCT.BIOL. V. 5 682 1998REFN ISSN 1072-8368PMID 9699630DOI 10.1038/1376 Variant Set Distributions Mapped Variants