Assessment of Structural Intolerance and Durability
General Structure Information 4i9w KCNK4 human two pore domain k+ channel traak (k2p4.1) – fab complex structure 2.75Å AUTH S.G.BROHAWN,E.B.CAMPBELL,R.MACKINNONTITL DOMAIN-SWAPPED CHAIN CONNECTIVITY AND GATED MEMBRANE ACCESSTITL 2 IN A FAB-MEDIATED CRYSTAL OF THE HUMAN TRAAK K+ CHANNEL.REF PROC.NATL.ACAD.SCI.USA V. 110 2129 2013REFN ISSN 0027-8424PMID 23341632DOI 10.1073/PNAS.1218950110 Variant Set Distributions Mapped Variants
General Structure Information 2yhf CLEC5A 1.9 angstrom crystal structure of clec5a 1.9Å AUTH A.A.WATSON,A.A.LEBEDEV,B.A.HALL,A.E.FENTON-MAY,AUTH 2 A.A.VAGIN,W.DEJNIRATTISAI,J.FELCE,J.MONGKOLSAPAYA,AUTH 3 A.S.PALMA,Y.LIU,T.FEIZI,G.R.SCREATON,G.N.MURSHUDOV,AUTH 4 C.A.OCALLAGHANTITL STRUCTURAL FLEXIBILITY OF THE MACROPHAGE DENGUETITL 2 VIRUS RECEPTOR CLEC5A: IMPLICATIONS FOR LIGANDTITL 3 BINDING AND SIGNALING.REF J.BIOL.CHEM. V. 286 24208 2011REFN ISSN 0021-9258PMID 21566123DOI 10.1074/JBC.M111.226142 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3lq9 DDIT4 crystal strucure of human redd1, a hypoxia-induced regulator of mtor 2.0Å AUTH S.VEGA-RUBIN-DE-CELIS,Z.ABDALLAH,L.KINCH,AUTH 2 N.V.GRISHIN,J.BRUGAROLAS,X.ZHANGTITL STRUCTURAL ANALYSIS AND FUNCTIONAL IMPLICATIONS OFTITL 2 THE NEGATIVE MTORC1 REGULATOR REDD1.REF BIOCHEMISTRY V. 49 2491 2010REFN ISSN 0006-2960PMID 20166753DOI 10.1021/BI902135E Variant Set Distributions Mapped Variants
General Structure Information 3gbj KIF13B crystal structure of the motor domain of kinesin kif13b bound with adp 2.1Å AUTH Y.TONG,L.SHEN,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESINTITL 2 KIF13B BOUND WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z4k NT5M structure of the d41n variant of the human mitochondrial deoxyribonucleotidase in complex with thymidine 3- monophosphate 1.75Å AUTH K.WALLDEN,B.RUZZENENTE,A.RINALDO-MATTHIS,V.BIANCHI,AUTH 2 P.NORDLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY OF THETITL 2 HUMAN MITOCHONDRIAL DEOXYRIBONUCLEOTIDASEREF STRUCTURE V. 13 1081 2005REFN ISSN 0969-2126PMID 16004879DOI 10.1016/J.STR.2005.04.023 Variant Set Distributions Mapped Variants
General Structure Information 3mk6 PANK3 substrate and inhibitor binding to pank 1.98Å AUTH R.LEONARDI,Y.M.ZHANG,M.K.YUN,R.ZHOU,F.Y.ZENG,W.LIN,J.CUI,AUTH 2 T.CHEN,C.O.ROCK,S.W.WHITE,S.JACKOWSKITITL MODULATION OF PANTOTHENATE KINASE 3 ACTIVITY BY SMALLTITL 2 MOLECULES THAT INTERACT WITH THE SUBSTRATE/ALLOSTERICTITL 3 REGULATORY DOMAIN.REF CHEM.BIOL. V. 17 892 2010REFN ISSN 1074-5521PMID 20797618DOI 10.1016/J.CHEMBIOL.2010.06.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3f1r FGF20 crystal structure of fgf20 dimer 2.5Å AUTH J.KALININA,S.A.BYRON,H.P.MAKARENKOVA,S.K.OLSEN,AUTH 2 A.V.ELISEENKOVA,W.J.LAROCHELLE,M.DHANABAL,S.BLAIS,AUTH 3 D.M.ORNITZ,L.A.DAY,T.A.NEUBERT,P.M.POLLOCK,AUTH 4 M.MOHAMMADITITL HOMODIMERIZATION CONTROLS THE FIBROBLAST GROWTHTITL 2 FACTOR 9 SUBFAMILYS RECEPTOR BINDING AND HEPARANTITL 3 SULFATE-DEPENDENT DIFFUSION IN THE EXTRACELLULARTITL 4 MATRIXREF MOL.CELL.BIOL. V. 29 4663 2009REFN ISSN 0270-7306PMID 19564416DOI 10.1128/MCB.01780-08 Variant Set Distributions Mapped Variants
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants