Assessment of Structural Intolerance and Durability
General Structure Information 1wrm DUSP22 crystal structure of jsp-1 1.5Å AUTH T.YOKOTA,Y.NARA,A.KASHIMA,K.MATSUBARA,S.MISAWA,AUTH 2 R.KATO,S.SUGIOTITL CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITYTITL 2 PHOSPHATASE, JNK STIMULATORY PHOSPHATASE-1, AT 1.5TITL 3 A RESOLUTIONREF PROTEINS V. 66 272 2006REFN ISSN 0887-3585PMID 17068812DOI 10.1002/PROT.21152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1uem ROBO2 solution structure of the first fibronectin type iii domain of human kiaa1568 protein -1.0Å AUTH H.LI,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN KIAA1568 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uw4 UPF2 the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 2f0x ACOT13 crystal structure and function of human thioesterase superfamily member 2(them2) 2.3Å AUTH Z.CHENG,F.SONG,X.SHAN,Z.WEI,Y.WANG,AUTH 2 D.DUNAWAY-MARIANO,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN THIOESTERASETITL 2 SUPERFAMILY MEMBER 2REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 349 172 2006REFN ISSN 0006-291XPMID 16934754DOI 10.1016/J.BBRC.2006.08.025 Variant Set Distributions Mapped Variants
General Structure Information 2yul SOX17 solution structure of the hmg box of human transcription factor sox-17 -1.0Å AUTH H.ABE,N.TOCHIO,K.MIYAMOTO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HMG BOX OF HUMANTITL 2 TRANSCRIPTION FACTOR SOX-17REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2epp PATZ1 solution structure of the first c2h2 type zinc finger domain of zinc finger protein 278 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 278REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ua9 TNKS2 crystal structure of human tankyrase 2 in complex with a selective inhibitor 2.15Å AUTH M.NARWAL,H.VENKANNAGARI,L.LEHTIOTITL STRUCTURAL BASIS OF SELECTIVE INHIBITION OF HUMANTITL 2 TANKYRASES.REF J.MED.CHEM. V. 55 1360 2012REFN ISSN 0022-2623PMID 22233320DOI 10.1021/JM201510P Variant Set Distributions Mapped Variants
General Structure Information 4iy4 CNNM2 structural and ligand binding properties of the bateman domain of human magnesium transporters cnnm2 and cnnm4 2.9Å AUTH M.A.CORRAL-RODRIGUEZ,M.STUIVER,J.A.ENCINAR,V.SPIWOK,AUTH 2 I.GOMEZ-GARCIA,I.OYENARTE,J.ERENO-ORBEA,H.TERASHIMA,AUTH 3 A.ACCARDI,T.DIERCKS,D.MULLER,L.A.MARTINEZ-CRUZTITL STRUCTURAL AND LIGAND BINDING PROPERTIES OF THE BATEMANTITL 2 DOMAIN OF HUMAN MAGNESIUM TRANSPORTERS CNNM2 AND CNNM4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pq1 MTPAP crystal structure of human mitochondrial poly(a) polymerase (papd1) 3.1Å AUTH Y.BAI,S.K.SRIVASTAVA,J.H.CHANG,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR DIMERIZATION AND ACTIVITY OF HUMANTITL 2 PAPD1, A NONCANONICAL POLY(A) POLYMERASE.REF MOL.CELL V. 41 311 2011REFN ISSN 1097-2765PMID 21292163DOI 10.1016/J.MOLCEL.2011.01.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4day RMI1 crystal structure of the rmi core complex with mm2 peptide from fancm 3.3Å AUTH K.A.HOADLEY,Y.XUE,C.LING,M.TAKATA,W.WANG,J.L.KECKTITL DEFINING THE MOLECULAR INTERFACE THAT CONNECTS THE FANCONITITL 2 ANEMIA PROTEIN FANCM TO THE BLOOM SYNDROME DISSOLVASOME.REF PROC.NATL.ACAD.SCI.USA V. 109 4437 2012REFN ISSN 0027-8424PMID 22392978DOI 10.1073/PNAS.1117279109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]