Assessment of Structural Intolerance and Durability
General Structure Information 3lpw TTN crystal structure of the fniii-tandem a77-a78 from the a-band of titin 1.65Å AUTH R.M.BUCHER,D.I.SVERGUN,C.MUHLE-GOLL,O.MAYANSTITL THE STRUCTURE OF THE FNIII TANDEM A77-A78 POINTS TO ATITL 2 PERIODICALLY CONSERVED ARCHITECTURE IN THE MYOSIN-BINDINGTITL 3 REGION OF TITINREF J.MOL.BIOL. V. 401 843 2010REFN ISSN 0022-2836PMID 20542041DOI 10.1016/J.JMB.2010.06.011 Variant Set Distributions Mapped Variants
General Structure Information 4c9y SKA1 structural basis for the microtubule binding of the human kinetochore ska complex 2.01Å AUTH M.A.ABAD,B.MEDINA,A.SANTAMARIA,J.ZOU,C.PLASBERG-HILL,AUTH 2 A.MADHUMALAR,U.JAYACHANDRAN,P.M.REDLI,J.RAPPSILBER,E.A.NIGG,AUTH 3 A.A.JEYAPRAKASHTITL STRUCTURAL BASIS FOR MICROTUBULE RECOGNITION BY THE HUMANTITL 2 KINETOCHORE SKA COMPLEX.REF NAT.COMMUN. V. 5 2964 2014REFN ISSN 2041-1723PMID 24413531DOI 10.1038/NCOMMS3964 Variant Set Distributions Mapped Variants
General Structure Information 4aj5 SKA3 crystal structure of the ska core complex 3.32Å AUTH A.A.JEYAPRAKASH,A.SANTAMARIA,U.JAYACHANDRAN,Y.W.CHAN,AUTH 2 C.BENDA,E.A.NIGG,E.CONTITITL STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE SKA COMPLEX,TITL 2 A KEY COMPONENT OF THE KINETOCHORE-MICROTUBULE INTERFACE.REF MOL.CELL V. 46 274 2012REFN ISSN 1097-2765PMID 22483620DOI 10.1016/J.MOLCEL.2012.03.005 Variant Set Distributions Mapped Variants
General Structure Information 4a0d PARG structure of unliganded human parg catalytic domain 1.75Å AUTH J.A.TUCKER,N.BENNETT,C.BRASSINGTON,S.T.DURANT,G.HASSALL,AUTH 2 G.HOLDGATE,M.MCALISTER,J.W.M.NISSINK,C.TRUMAN,M.WATSONTITL STRUCTURES OF THE HUMAN POLY (ADP-RIBOSE) GLYCOHYDROLASETITL 2 CATALYTIC DOMAIN CONFIRM CATALYTIC MECHANISM AND EXPLAINTITL 3 INHIBITION BY ADP-HPD DERIVATIVES.REF PLOS ONE V. 7 50889 2012REFN ISSN 1932-6203PMID 23251397DOI 10.1371/JOURNAL.PONE.0050889 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2wh5 ACBD4 crystal structure of human acyl-coa binding domain 4 complexed with stearoyl-coa 2.6Å AUTH N.SHAFQAT,W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ACYL-COA BINDING DOMAINTITL 2 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uit DLG5 solution structure of rsgi ruh-006, the third pdz domain of hdlg5 (kiaa0583) protein [homo sapiens] -1.0Å AUTH T.ABE,H.HIROTA,N.KOBAYASHI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-006, THE THIRD PDZTITL 2 DOMAIN OF HDLG5 (KIAA0583) PROTEIN [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3mcf NUDT10 crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha 2.0Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,AUTH 4 S.KOL,T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,AUTH 5 H.SCHULER,P.SCHUTZ,M.I.SIPONEN,A.G.THORSELL,AUTH 6 S.VAN DER BERG,E.WAHLBERG,J.WEIGELT,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN DIPHOSPHOINOSITOLTITL 2 POLYPHOSPHATE PHOSPHOHYDROLASE 3-ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mb4 PBRM1 crystal structure of the fifth bromodomain of human poly-bromodomain containing protein 1 (pb1) with nmp 1.66Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2hwx SMG6 structure of human smg6 e1282c pin domain mutant. 1.9Å AUTH F.GLAVAN,I.BEHM-ANSMANT,E.IZAURRALDE,E.CONTITITL STRUCTURES OF THE PIN DOMAINS OF SMG6 AND SMG5TITL 2 REVEAL A NUCLEASE WITHIN THE MRNA SURVEILLANCETITL 3 COMPLEX.REF EMBO J. V. 25 5117 2006REFN ISSN 0261-4189PMID 17053788DOI 10.1038/SJ.EMBOJ.7601377 Variant Set Distributions Mapped Variants
General Structure Information 2wm1 ACMSD the crystal structure of human alpha-amino-beta- carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between nad synthesis and glycolysis 2.01Å AUTH S.GARAVAGLIA,S.PEROZZI,L.GALEAZZI,N.RAFFAELLI,AUTH 2 M.RIZZITITL THE CRYSTAL STRUCTURE OF HUMAN ALPHA-AMINO-BETA-TITL 2 CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASETITL 3 IN COMPLEX WITH 1,3-DIHYDROXYACETONEPHOSPHATETITL 4 SUGGESTS A REGULATORY LINK BETWEEN NAD SYNTHESISTITL 5 […]