Assessment of Structural Intolerance and Durability
General Structure Information 2fv2 RQCD1 crystal structure analysis of human rcd-1 conserved region 2.2Å AUTH R.G.GARCES,W.GILLON,E.F.PAITITL ATOMIC MODEL OF HUMAN RCD-1 REVEALS ANTITL 2 ARMADILLO-LIKE-REPEAT PROTEIN WITH IN VITROTITL 3 NUCLEIC ACID BINDING PROPERTIES.REF PROTEIN SCI. V. 16 176 2007REFN ISSN 0961-8368PMID 17189474DOI 10.1110/PS.062600507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4n4f CREBBP crystal structure of the bromodomain-phd finger module of human transcriptional co-activator cbp in complex with di-acetylated histone 4 peptide (h412ack16ac). 1.83Å AUTH A.N.PLOTNIKOV,S.YANG,T.J.ZHOU,E.RUSINOVA,A.FRASCA,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO ACETYLATED-HISTONE H4 RECOGNITIONTITL 2 BY THE BROMODOMAIN-PHD FINGER MODULE OF HUMANTITL 3 TRANSCRIPTIONAL COACTIVATOR CBP.REF STRUCTURE V. 22 353 2014REFN ISSN 0969-2126PMID 24361270DOI 10.1016/J.STR.2013.10.021 […]
General Structure Information 4fjv OTUB2 crystal structure of human otubain2 and ubiquitin complex 2.05Å AUTH M.ALTUN,T.S.WALTER,H.B.KRAMER,P.HERR,A.IPHOFER,J.BOSTROM,AUTH 2 Y.DAVID,A.KOMSANY,N.TERNETTE,A.NAVON,D.I.STUART,J.REN,AUTH 3 B.M.KESSLERTITL THE HUMAN OTUBAIN2-UBIQUITIN STRUCTURE PROVIDES INSIGHTSTITL 2 INTO THE CLEAVAGE SPECIFICITY OF POLY-UBIQUITIN-LINKAGES.REF PLOS ONE V. 10 15344 2015REFN ESSN 1932-6203PMID 25590432DOI 10.1371/JOURNAL.PONE.0115344 Variant Set Distributions Mapped Variants
General Structure Information 2izv SOCS4 crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution 2.55Å AUTH A.N.BULLOCK,M.C.RODRIGUEZ,J.E.DEBRECZENI,Z.SONGYANG,S.KNAPPTITL STRUCTURE OF THE SOCS4-ELONGINB/C COMPLEX REVEALS ATITL 2 DISTINCT SOCS BOX INTERFACE AND THE MOLECULAR BASIS FORTITL 3 SOCS-DEPENDENT EGFR DEGRADATION.REF STRUCTURE V. 15 1493 2007REFN ISSN 0969-2126PMID 17997974DOI 10.1016/J.STR.2007.09.016 Variant Set Distributions Mapped […]
General Structure Information 2edi UBE2F solution structure of the uq_con domain from human nedd8- conjugating enzyme nce2 -1.0Å AUTH H.ENDO,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UQ_CON DOMAIN FROM HUMANTITL 2 NEDD8-CONJUGATING ENZYME NCE2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wwm TTN crystal structure of the titin m10-obscurin like 1 ig complex in space group p1 2.3Å AUTH S.PERNIGO,A.FUKUZAWA,M.BERTZ,M.HOLT,M.RIEF,R.A.STEINER,AUTH 2 M.GAUTELTITL STRUCTURAL INSIGHT INTO M-BAND ASSEMBLY AND MECHANICS FROMTITL 2 THE TITIN-OBSCURIN-LIKE-1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 2908 2010REFN ISSN 0027-8424PMID 20133654DOI 10.1073/PNAS.0913736107 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i46 ACD crystal structure of human tpp1 2.7Å AUTH F.WANG,E.R.PODELL,A.J.ZAUG,Y.YANG,P.BACIU,T.R.CECH,AUTH 2 M.LEITITL THE POT1-TPP1 TELOMERE COMPLEX IS A TELOMERASETITL 2 PROCESSIVITY FACTOR.REF NATURE V. 445 506 2007REFN ISSN 0028-0836PMID 17237768DOI 10.1038/NATURE05454 Variant Set Distributions Mapped Variants
General Structure Information 4fr4 STK32A crystal structure of human serine/threonine-protein kinase 32a (yank1) 2.29Å AUTH A.CHAIKUAD,J.M.ELKINS,T.KROJER,P.MAHAJAN,S.GOUBIN,M.SZKLARZ,AUTH 2 A.TUMBER,J.WANG,P.SAVITSKY,B.SHRESTHA,N.DAGA,S.PICAUD,AUTH 3 O.FEDOROV,C.K.ALLERSTON,S.V.A.LATWIEL,M.VOLLMAR,P.CANNING,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASETITL 2 32A (YANK1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hbw FGF13 crystal structure of human fibroblast growth factor homologous factor 2a (fhf2a), also referred to as fibroblast growth factor 13a (fgf13a) 1.9Å AUTH R.GOETZ,K.DOVER,F.LAEZZA,N.SHTRAIZENT,X.HUANG,AUTH 2 D.TCHETCHIK,A.V.ELISEENKOVA,C.F.XU,T.A.NEUBERT,AUTH 3 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL CRYSTAL STRUCTURE OF A FIBROBLAST GROWTH FACTORTITL 2 HOMOLOGOUS FACTOR (FHF) DEFINES A CONSERVED SURFACETITL 3 ON FHFS FOR BINDING AND MODULATION OF […]
General Structure Information 2ctt DNAJA3 solution structure of zinc finger domain from human dnaj subfamily a menber 3 -1.0Å AUTH N.KOBAYASHI,N.TOCHIO,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF ZINC FINGER DOMAIN FROMTITL 2 HUMAN DNAJ SUBFAMILY A MENBER 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants