Assessment of Structural Intolerance and Durability
General Structure Information 2mb9 BCL10 human bcl10 card -1.0Å AUTH Q.QIAO,C.YANG,C.ZHENG,L.FONTAN,L.DAVID,X.YU,C.BRACKEN,AUTH 2 M.ROSEN,A.MELNICK,E.H.EGELMAN,H.WUTITL STRUCTURAL ARCHITECTURE OF THE CARMA1/BCL10/MALT1TITL 2 SIGNALOSOME: NUCLEATION-INDUCED FILAMENTOUS ASSEMBLY.REF MOL.CELL V. 51 766 2013REFN ISSN 1097-2765PMID 24074955DOI 10.1016/J.MOLCEL.2013.08.032 Variant Set Distributions Mapped Variants
General Structure Information 2keo HERC2 solution nmr structure of human protein hs00059, cytochrome-b5-like domain of the herc2 e3 ligase. northeast structural genomics consortium (nesg) target ht98a -1.0Å AUTH A.LEMAK,A.GUTMANAS,C.FARES,H.QUYANG,Y.LI,G.MONTELIONE,AUTH 2 C.ARROWSMITH,S.DHE-PAGANONTITL SOLUTION NMR STRUCTURE OF HUMAN PROTEIN HS00059REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4iu7 ESR1 crystal structure of the estrogen receptor alpha ligand-binding domain in complex with constrained way-derivative, 2b 2.29Å AUTH S.SRINIVASAN,J.C.NWACHUKWU,A.A.PARENT,V.CAVETT,J.NOWAK,AUTH 2 T.S.HUGHES,D.J.KOJETIN,J.A.KATZENELLENBOGEN,K.W.NETTLESTITL LIGAND BINDING DYNAMICS REWIRE CELLULAR SIGNALING VIATITL 2 ESTROGEN RECEPTOR-ALPHAREF NAT.CHEM.BIOL. V. 9 326 2013REFN ISSN 1552-4450PMID 23524984DOI 10.1038/NCHEMBIO.1214 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1aap APP x-ray crystal structure of the protease inhibitor domain of alzheimers amyloid beta-protein precursor 1.5Å AUTH T.R.HYNES,M.RANDAL,L.A.KENNEDY,C.EIGENBROT,AUTH 2 A.A.KOSSIAKOFFTITL X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITORTITL 2 DOMAIN OF ALZHEIMERS AMYLOID BETA-PROTEINTITL 3 PRECURSOR.REF BIOCHEMISTRY V. 29 10018 1990REFN ISSN 0006-2960PMID 2125487DOI 10.1021/BI00495A002 Variant Set Distributions Mapped Variants
General Structure Information 3nxp F2 crystal structure of human prethrombin-1 2.2Å AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h61 S100B x-ray structure of human ca2+-loaded s100b 1.9Å AUTH T.OSTENDORP,E.LECLERC,A.GALICHET,M.KOCH,N.DEMLING,B.WEIGLE,AUTH 2 C.W.HEIZMANN,P.M.KRONECK,G.FRITZTITL STRUCTURAL AND FUNCTIONAL INSIGHTS INTO RAGE ACTIVATION BYTITL 2 MULTIMERIC S100B.REF EMBO J. V. 26 3868 2007REFN ISSN 0261-4189PMID 17660747DOI 10.1038/SJ.EMBOJ.7601805 Variant Set Distributions Mapped Variants
General Structure Information 4i8v CYP1A1 human cytochrome p450 1a1 in complex with alpha-naphthoflavone 2.6Å AUTH A.A.WALSH,G.D.SZKLARZ,E.E.SCOTTTITL HUMAN CYTOCHROME P450 1A1 STRUCTURE AND UTILITY INTITL 2 UNDERSTANDING DRUG AND XENOBIOTIC METABOLISM.REF J.BIOL.CHEM. V. 288 12932 2013REFN ISSN 0021-9258PMID 23508959DOI 10.1074/JBC.M113.452953 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4a1h PMP2 human myelin p2 protein, k45s mutant 2.2Å AUTH M.LEHTIMAKI,P.KURSULATITL STRUCTURE-FUNCTION RELATIONSHIPS IN THE MYELIN PERIPHERALTITL 2 MEMBRANE PROTEIN P2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1fnf FN1 fragment of human fibronectin encompassing type-iii repeats 7 through 10 2.0Å AUTH D.J.LEAHY,I.AUKHIL,H.P.ERICKSONTITL 2.0 A CRYSTAL STRUCTURE OF A FOUR-DOMAIN SEGMENTTITL 2 OF HUMAN FIBRONECTIN ENCOMPASSING THE RGD LOOP ANDTITL 3 SYNERGY REGION.REF CELL(CAMBRIDGE,MASS.) V. 84 155 1996REFN ISSN 0092-8674PMID 8548820DOI 10.1016/S0092-8674(00)81002-8 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]