Assessment of Structural Intolerance and Durability
General Structure Information 3zqk VWF von willebrand factor a2 domain with calcium 1.7Å AUTH A.J.JAKOBI,A.MASHAGHI,S.J.TANS,E.G.HUIZINGATITL CALCIUM MODULATES FORCE SENSING BY THE VON WILLEBRANDTITL 2 FACTOR A2 DOMAIN.REF NAT.COMMUN. V. 2 385 2011REFN ISSN 2041-1723PMID 21750539DOI 10.1038/NCOMMS1385 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1a9w HBE1 human embryonic gower ii carbonmonoxy hemoglobin 2.9Å AUTH A.J.SUTHERLAND-SMITH,H.M.BAKER,O.M.HOFMANN,AUTH 2 T.BRITTAIN,E.N.BAKERTITL CRYSTAL STRUCTURE OF A HUMAN EMBRYONICTITL 2 HAEMOGLOBIN: THE CARBONMONOXY FORM OF GOWER IITITL 3 (ALPHA2 EPSILON2) HAEMOGLOBIN AT 2.9 A RESOLUTION.REF J.MOL.BIOL. V. 280 475 1998REFN ISSN 0022-2836PMID 9665850DOI 10.1006/JMBI.1998.1868 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1dmw PAH crystal structure of double truncated human phenylalanine hydroxylase with bound 7,8-dihydro-l-biopterin 2.0Å AUTH H.ERLANDSEN,E.BJORGO,T.FLATMARK,R.C.STEVENSTITL CRYSTAL STRUCTURE AND SITE-SPECIFIC MUTAGENESIS OFTITL 2 PTERIN-BOUND HUMAN PHENYLALANINE HYDROXYLASE.REF BIOCHEMISTRY V. 39 2208 2000REFN ISSN 0006-2960PMID 10694386DOI 10.1021/BI992531+ Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j78 GC crystallographic analysis of the human vitamin d binding protein 2.31Å AUTH C.VERBOVEN,A.RABIJNS,M.DE MAEYER,H.VAN BAELEN,AUTH 2 R.BOUILLON,C.DE RANTERTITL A STRUCTURAL BASIS FOR THE UNIQUE BINDING FEATURESTITL 2 OF THE HUMAN VITAMIN D-BINDING PROTEIN.REF NAT.STRUCT.BIOL. V. 9 131 2002REFN ISSN 1072-8368PMID 11799400DOI 10.1038/NSB754 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2p5x ASMTL crystal structure of maf domain of human n-acetylserotonin o- methyltransferase-like protein 2.0Å AUTH A.TCHIGVINTSEV,D.TCHIGVINTSEV,R.FLICK,A.POPOVIC,A.DONG,X.XU,AUTH 2 G.BROWN,W.LU,H.WU,H.CUI,L.DOMBROWSKI,J.C.JOO,N.BELOGLAZOVA,AUTH 3 J.MIN,A.SAVCHENKO,A.A.CAUDY,J.D.RABINOWITZ,A.G.MURZIN,AUTH 4 A.F.YAKUNINTITL BIOCHEMICAL AND STRUCTURAL STUDIES OF CONSERVED MAF PROTEINSTITL 2 REVEALED NUCLEOTIDE PYROPHOSPHATASES WITH A PREFERENCE FORTITL 3 MODIFIED NUCLEOTIDES.REF CHEM.BIOL. V. 20 1386 2013REFN ISSN 1074-5521PMID 24210219DOI 10.1016/J.CHEMBIOL.2013.09.011 Variant Set […]
General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]
General Structure Information 3rbg CRTAM crystal structure analysis of class-i mhc restricted t-cell associated molecule 2.3Å AUTH R.RUBINSTEIN,U.A.RAMAGOPAL,S.G.NATHENSON,S.C.ALMO,A.FISERTITL FUNCTIONAL CLASSIFICATION OF IMMUNE REGULATORY PROTEINS.REF STRUCTURE V. 21 766 2013REFN ISSN 0969-2126PMID 23583034DOI 10.1016/J.STR.2013.02.022 Variant Set Distributions Mapped Variants
General Structure Information 2y3i PGK1 the structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride 2.9Å AUTH P.LALLEMAND,L.CHALOIN,B.ROY,T.BARMAN,M.W.BOWLER,C.LIONNETITL INTERACTION OF HUMAN 3-PHOSPHOGLYCERATE KINASE WITH ITS TWOTITL 2 SUBSTRATES: IS SUBSTRATE ANTAGONISM A KINETIC ADVANTAGE?REF J.MOL.BIOL. V. 409 742 2011REFN ISSN 0022-2836PMID 21549713DOI 10.1016/J.JMB.2011.04.048 Variant Set […]
General Structure Information 3kls C5 structure of complement c5 in complex with ssl7 3.6Å AUTH N.S.LAURSEN,N.GORDON,S.HERMANS,N.LORENZ,N.JACKSON,B.WINES,AUTH 2 E.SPILLNER,J.B.CHRISTENSEN,M.JENSEN,F.FREDSLUND,M.BJERRE,AUTH 3 L.SOTTRUP-JENSEN,J.D.FRASER,G.R.ANDERSENTITL STRUCTURAL BASIS FOR INHIBITION OF COMPLEMENT C5 BY THE SSL7TITL 2 PROTEIN FROM STAPHYLOCOCCUS AUREUSREF PROC.NATL.ACAD.SCI.USA V. 107 3681 2010REFN ISSN 0027-8424PMID 20133685DOI 10.1073/PNAS.0910565107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3q91 NUDT14 crystal structure of human uridine diphosphate glucose pyrophosphatase (nudt14) 2.7Å AUTH L.TRESAUGUES,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,AUTH 4 T.KOTENYOVA,E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,AUTH 5 H.SCHULER,P.SCHUTZ,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN URIDINE DIPHOSPHATE GLUCOSETITL 2 PYROPHOSPHATASE (NUDT14)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]