Assessment of Structural Intolerance and Durability
General Structure Information 3lqz HLA-DPA1 crystal structure of hla-dp2 3.25Å AUTH S.DAI,G.A.MURPHY,F.CRAWFORD,D.G.MACK,M.T.FALTA,P.MARRACK,AUTH 2 J.W.KAPPLER,A.P.FONTENOTTITL CRYSTAL STRUCTURE OF HLA-DP2 AND IMPLICATIONS FOR CHRONICTITL 2 BERYLLIUM DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 107 7425 2010REFN ISSN 0027-8424PMID 20356827DOI 10.1073/PNAS.1001772107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rk9 PVALB solution structure of human alpha-parvalbumin (minimized average structure) -1.0Å AUTH I.BAIG,I.BERTINI,C.DEL BIANCO,Y.K.GUPTA,Y.-M.LEE,AUTH 2 C.LUCHINAT,A.QUATTRONETITL PARAMAGNETISM-BASED REFINEMENT STRATEGY FOR THETITL 2 SOLUTION STRUCTURE OF HUMAN ALPHA-PARVALBUMINREF BIOCHEMISTRY V. 43 5562 2004REFN ISSN 0006-2960PMID 15122922DOI 10.1021/BI035879K Variant Set Distributions Mapped Variants
General Structure Information 2q4g RNH1 ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i 1.95Å AUTH R.J.JOHNSON,J.G.MCCOY,C.A.BINGMAN,G.N.PHILLIPS JR.,AUTH 2 R.T.RAINESTITL INHIBITION OF HUMAN PANCREATIC RIBONUCLEASE BY THE HUMANTITL 2 RIBONUCLEASE INHIBITOR PROTEIN.REF J.MOL.BIOL. V. 368 434 2007REFN ISSN 0022-2836PMID 17350650DOI 10.1016/J.JMB.2007.02.005 Variant Set Distributions Mapped Variants
General Structure Information 1b72 HOXB1 pbx1, homeobox protein hox-b1/dna ternary complex 2.35Å AUTH D.E.PIPER,A.H.BATCHELOR,C.P.CHANG,M.L.CLEARY,AUTH 2 C.WOLBERGERTITL STRUCTURE OF A HOXB1-PBX1 HETERODIMER BOUND TOTITL 2 DNA: ROLE OF THE HEXAPEPTIDE AND A FOURTHTITL 3 HOMEODOMAIN HELIX IN COMPLEX FORMATION.REF CELL(CAMBRIDGE,MASS.) V. 96 587 1999REFN ISSN 0092-8674PMID 10052460DOI 10.1016/S0092-8674(00)80662-5 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1qty FLT1 vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor 2.7Å AUTH M.A.STAROVASNIK,H.W.CHRISTINGER,C.WIESMANN,AUTH 2 M.A.CHAMPE,A.M.DE VOS,N.J.SKELTONTITL SOLUTION STRUCTURE OF THE VEGF-BINDING DOMAIN OFTITL 2 FLT-1: COMPARISON OF ITS FREE AND BOUND STATES.REF J.MOL.BIOL. V. 293 531 1999REFN ISSN 0022-2836PMID 10543948DOI 10.1006/JMBI.1999.3134 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2k21 KCNE1 nmr structure of human kcne1 in lmpg micelles at ph 6.0 and 40 degree c -1.0Å AUTH C.KANG,C.TIAN,F.D.SONNICHSEN,J.A.SMITH,J.MEILER,AUTH 2 A.L.GEORGE,C.G.VANOYE,H.J.KIM,C.R.SANDERSTITL STRUCTURE OF KCNE1 AND IMPLICATIONS FOR HOW ITTITL 2 MODULATES THE KCNQ1 POTASSIUM CHANNEL.REF BIOCHEMISTRY V. 47 7999 2008REFN ISSN 0006-2960PMID 18611041DOI 10.1021/BI800875Q Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4bj3 ITGA2 integrin alpha2 i domain e318w-collagen complex 3.04Å AUTH F.CARAFOLI,S.W.HAMAIA,D.BIHAN,E.HOHENESTER,R.W.FARNDALETITL AN ACTIVATING MUTATION REVEALS A SECOND BINDING MODE OF THETITL 2 INTEGRIN ALPHA2 I DOMAIN TO THE GFOGER MOTIF IN COLLAGENS.REF PLOS ONE V. 8 69833 2013REFN ISSN 1932-6203PMID 23922814DOI 10.1371/JOURNAL.PONE.0069833 Variant Set Distributions Mapped Variants
General Structure Information 3n46 FDPS human fpps complex with nov_980 and zoledronic acid/mg2+ 2.35Å AUTH W.JAHNKE,J.M.RONDEAU,S.COTESTA,A.MARZINZIK,X.PELLE,M.GEISER,AUTH 2 A.STRAUSS,M.GOTTE,F.BITSCH,R.HEMMIG,C.HENRY,S.LEHMANN,AUTH 3 J.F.GLICKMAN,T.P.RODDY,S.J.STOUT,J.R.GREENTITL ALLOSTERIC NON-BISPHOSPHONATE FPPS INHIBITORS IDENTIFIED BYTITL 2 FRAGMENT-BASED DISCOVERY.REF NAT.CHEM.BIOL. V. 6 660 2010REFN ISSN 1552-4450PMID 20711197DOI 10.1038/NCHEMBIO.421 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2csa CHRM3 structure of the m3 muscarinic acetylcholine receptor basolateral sorting signal -1.0Å AUTH H.A.IVERSON,D.FOX,L.S.NADLER,R.E.KLEVIT,AUTH 2 N.M.NATHANSONTITL IDENTIFICATION AND STRUCTURAL DETERMINATION OF THETITL 2 M3 MUSCARINIC ACETYLCHOLINE RECEPTOR BASOLATERALTITL 3 SORTING SIGNAL.REF J.BIOL.CHEM. V. 280 24568 2005REFN ISSN 0021-9258PMID 15870063DOI 10.1074/JBC.M501264200 Variant Set Distributions Mapped Variants
General Structure Information 3azn HIST1H2BJ crystal structure of human nucleosome core particle containing h4k91q mutation 3.0Å AUTH W.IWASAKI,H.TACHIWANA,K.KAWAGUCHI,T.SHIBATA,W.KAGAWA,AUTH 2 H.KURUMIZAKATITL COMPREHENSIVE STRUCTURAL ANALYSIS OF MUTANT NUCLEOSOMESTITL 2 CONTAINING LYSINE TO GLUTAMINE (KQ) SUBSTITUTIONS IN THE H3TITL 3 AND H4 HISTONE-FOLD DOMAINSREF BIOCHEMISTRY V. 50 7822 2011REFN ISSN 0006-2960PMID 21812398DOI 10.1021/BI201021H Variant Set Distributions Ripley’s K […]