2Q4G.W | RNH1 – ASTRID

2Q4G.W | RNH1

General Structure Information

PDB ID	2q4g
HGNC Gene Label(s)	RNH1
Structure Name	ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Resolution	1.95Å
Reference	AUTH R.J.JOHNSON,J.G.MCCOY,C.A.BINGMAN,G.N.PHILLIPS JR.,AUTH 2 R.T.RAINESTITL INHIBITION OF HUMAN PANCREATIC RIBONUCLEASE BY THE HUMANTITL 2 RIBONUCLEASE INHIBITOR PROTEIN.REF J.MOL.BIOL. V. 368 434 2007REFN ISSN 0022-2836PMID 17350650DOI 10.1016/J.JMB.2007.02.005

Variant Set Distributions

ExAC Variants

Number Of Residues	460
Number Of SNVs	134
Number Of Permutations	47853
Optimal Distance Threshold	21.0
K Statistic	0.229
p-value	0.207

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:502156		L>V	W:2	(53.89, 70.99, 17.83)
11:502117	rs371088490	S>G	W:15	(40.84, 81.25, -7.89)
11:502114		D>N	W:16	(42.94, 84.72, -8.64)
11:502090	rs376817899	P>S	W:24	(48.60, 82.07, 3.89)
11:502080		Q>L	W:27	(53.45, 82.07, 4.39)
11:502065		V>A	W:32	(52.81, 71.76, -0.10)
11:502066		V>I	W:32	(52.81, 71.76, -0.10)
11:500647		D>N	W:36	(47.03, 69.08, -12.18)
11:500634	COSM4033458	T>M	W:40	(51.47, 79.79, -13.83)
11:500629	rs368410952	A>P	W:42	(53.49, 83.56, -12.77)
11:500626	rs149360262	R>W	W:43	(49.73, 80.84, -10.45)
11:500614		I>V	W:47	(55.07, 79.64, -4.68)
11:500598		R>Q	W:52	(62.16, 84.01, 0.38)
11:500590		P>S	W:55	(60.09, 78.53, 8.73)
11:500570		N>K	W:61	(54.61, 67.94, -4.98)
11:500565		R>H	W:63	(53.33, 64.77, -10.29)
11:500566	rs200324639 COSM1354252	R>C	W:63	(53.33, 64.77, -10.29)
11:500559		N>S	W:65	(52.10, 72.04, -12.78)
11:500548		D>N	W:69	(62.68, 76.02, -17.72)
11:500539	rs150705572	V>M	W:72	(61.51, 75.75, -11.83)
11:500502		C>Y	W:84	(64.95, 76.17, 4.46)
11:500493		Q>R	W:87	(63.41, 66.92, 4.19)
11:499992		N>H	W:93	(54.84, 66.53, -15.62)
11:499979	rs142005826	T>M	W:97	(64.43, 71.62, -20.17)
11:499971		G>S	W:100	(67.34, 74.15, -16.25)
11:499967		C>Y	W:101	(69.62, 71.74, -15.38)
11:499964		G>E	W:102	(71.68, 74.79, -14.06)
11:499944	rs117254759	R>C	W:109	(76.66, 73.14, -5.71)
11:499928		L>P	W:114	(67.22, 68.18, -0.51)
11:499910		S>I	W:120	(60.17, 62.16, -13.54)
11:499877	rs202159454	L>P	W:131	(74.91, 70.39, -15.98)
11:499869		E>K	W:134	(78.76, 69.26, -12.49)
11:499863		L>V	W:136	(74.37, 65.97, -7.53)
11:499856		D>G	W:138	(78.81, 69.75, -3.93)
11:499853		P>L	W:139	(80.14, 68.44, -0.85)
11:499848	rs540753529	C>G	W:141	(74.73, 67.21, -2.05)
11:499844	rs145322972	R>H	W:142	(74.29, 66.54, 2.28)
11:499845	rs201983047	R>C	W:142	(74.29, 66.54, 2.28)
11:499175		C>R	W:151	(64.56, 62.01, -18.38)
11:499169		L>V	W:153	(68.26, 59.82, -19.83)
11:499165	rs145455574	S>L	W:154	(71.10, 57.73, -22.84)
11:499162		A>D	W:155	(74.11, 55.61, -22.16)
11:499163		A>S	W:155	(74.11, 55.61, -22.16)
11:499151	rs530897378	E>K	W:159	(79.97, 56.93, -16.69)
11:499141	rs565166853	A>V	W:162	(78.34, 56.73, -11.26)
11:499136	rs150077141	V>M	W:164	(76.80, 60.64, -7.92)
11:499133	rs201774795	L>F	W:165	(76.33, 56.32, -6.91)
11:499129		R>K	W:166	(82.51, 55.94, -7.26)
11:499127		A>S	W:167	(79.81, 60.66, -3.76)
11:499120	rs17585	P>L	W:169	(77.98, 57.45, 1.22)
11:499111		K>R	W:172	(68.67, 55.72, 1.00)
11:499112		K>E	W:172	(68.67, 55.72, 1.00)
11:499102		T>M	W:175	(64.57, 55.58, -10.40)
11:499100	rs543262307	V>I	W:176	(66.59, 55.07, -14.46)
11:499085		I>V	W:181	(70.62, 53.15, -20.24)
11:499081		N>S	W:182	(71.19, 50.61, -23.65)
11:499082		N>D	W:182	(71.19, 50.61, -23.65)
11:499077		E>D	W:183	(74.25, 45.81, -22.24)
11:499075		A>V	W:184	(76.34, 49.73, -21.03)
11:499070		V>I	W:186	(73.01, 48.98, -17.03)
11:499066	rs17849355	R>H	W:187	(78.23, 46.50, -18.33)
11:499039		S>F	W:196	(79.56, 52.49, -3.84)
11:499021		A>V	W:202	(66.19, 50.99, -4.20)
11:498925	COSM927745	S>N	W:207	(61.70, 50.15, -19.37)
11:498922	rs142344675	C>Y	W:208	(66.01, 50.48, -19.36)
11:498920	rs200822615 COSM3415918	G>S	W:209	(67.33, 47.80, -21.83)
11:498911	rs150759500	S>P	W:212	(70.34, 39.01, -20.62)
11:498904		N>S	W:214	(72.79, 43.45, -17.93)
11:498898		R>P	W:216	(77.56, 39.27, -15.17)
11:498899		R>W	W:216	(77.56, 39.27, -15.17)
11:498886		G>D	W:220	(76.52, 41.77, -8.07)
11:498887		G>S	W:220	(76.52, 41.77, -8.07)
11:498883		I>T	W:221	(74.31, 44.64, -7.31)
11:498877		A>V	W:223	(75.78, 40.00, -4.14)
11:498872		K>E	W:225	(74.55, 46.38, -1.72)
11:498868		A>D	W:226	(72.36, 43.95, 2.48)
11:498865	rs142171562	S>L	W:227	(70.66, 47.27, 1.91)
11:498859		R>Q	W:229	(65.72, 46.20, 1.96)
11:498860		R>W	W:229	(65.72, 46.20, 1.96)
11:498853		L>Q	W:231	(65.33, 44.96, -7.74)
11:498854	COSM338437	L>V	W:231	(65.33, 44.96, -7.74)
11:498839		N>D	W:236	(63.43, 44.52, -19.28)
11:498836		K>E	W:237	(63.22, 40.89, -23.77)
11:498817		M>T	W:243	(65.82, 34.82, -13.80)
11:498814		A>V	W:244	(69.68, 32.20, -13.69)
11:498808		L>P	W:246	(69.53, 37.17, -11.15)
11:498784		S>I	W:254	(73.43, 38.52, 2.46)
11:498785	rs528683953	S>G	W:254	(73.43, 38.52, 2.46)
11:498776	rs374580179	L>I	W:257	(65.30, 41.53, -1.91)
11:498625		I>T	W:262	(60.10, 40.21, -12.49)
11:498622		W>S	W:263	(56.56, 44.74, -15.29)
11:498604		A>V	W:269	(58.66, 27.73, -16.61)
11:498600	rs572994029	K>N	W:270	(63.84, 27.29, -17.35)
11:498599		G>S	W:271	(62.35, 30.38, -14.50)
11:498592	rs377703417	G>E	W:273	(62.56, 27.20, -10.97)
11:498593		G>R	W:273	(62.56, 27.20, -10.97)
11:498590		D>H	W:274	(65.35, 29.34, -11.71)
11:498580	rs553116541	R>H	W:277	(65.72, 26.99, -7.97)
11:498581	rs146384142	R>C	W:277	(65.72, 26.99, -7.97)
11:498569		A>T	W:281	(65.59, 29.96, 0.45)
11:498560	rs142181492	S>G	W:284	(63.62, 37.68, 2.67)
11:498521		D>Y	W:297	(48.99, 26.20, -16.32)
11:498515		G>S	W:299	(54.28, 27.83, -13.42)
11:498511		A>V	W:300	(51.74, 27.74, -11.31)
11:498506		L>V	W:302	(56.70, 25.09, -10.45)
11:498503	rs17849763	L>M	W:303	(55.10, 29.21, -8.28)
11:498495		E>D	W:305	(55.09, 22.61, -6.10)
11:498482		P>T	W:310	(58.19, 24.14, 4.22)
11:498467		E>Q	W:315	(53.17, 39.03, 2.29)
11:498463	rs150334174	S>L	W:316	(52.57, 39.38, -2.51)
11:498464		S>T	W:316	(52.57, 39.38, -2.51)
11:498125		F>L	W:324	(47.96, 31.28, -15.09)
11:498072		F>L	W:341	(53.50, 33.00, 5.63)
11:498055	rs372343001	I>T	W:347	(44.91, 35.90, -10.42)
11:498052	rs572871991	S>T	W:348	(44.27, 39.44, -12.94)
11:498042		R>S	W:351	(42.02, 33.17, -20.49)
11:498029		G>S	W:356	(38.45, 28.31, -11.12)
11:498026	COSM1354234	V>M	W:357	(36.82, 31.18, -9.48)
11:498022	rs577836583	R>Q	W:358	(33.22, 27.50, -8.16)
11:498023	rs374635782	R>W	W:358	(33.22, 27.50, -8.16)
11:498001		G>D	W:365	(36.57, 28.61, 2.72)
11:498002	rs201659542	G>S	W:365	(36.57, 28.61, 2.72)
11:497995	rs143037442	P>L	W:367	(38.55, 26.62, 7.83)
11:497980	rs201027907	R>Q	W:372	(43.82, 41.23, 4.36)
11:497981		R>W	W:372	(43.82, 41.23, 4.36)
11:495040		D>N	W:380	(36.65, 34.88, -18.09)
11:495010		A>T	W:390	(28.73, 34.94, -1.49)
11:495007	rs113396594	A>T	W:391	(29.61, 32.22, 0.66)
11:494989		H>Y	W:397	(35.37, 35.67, 8.43)
11:494979	COSM542884	R>H	W:400	(39.30, 42.25, 5.36)
11:494980	rs200406171	R>C	W:400	(39.30, 42.25, 5.36)
11:494964		S>N	W:405	(36.81, 44.51, -12.11)
11:494958		N>S	W:407	(34.59, 40.30, -15.21)
11:494945		D>E	W:411	(21.94, 42.07, -11.77)
11:494943		A>V	W:412	(22.35, 37.78, -10.30)
11:494944	rs370277229	A>T	W:412	(22.35, 37.78, -10.30)
11:494941		G>S	W:413	(25.47, 38.09, -9.01)
11:494932		Q>E	W:416	(24.47, 36.24, -5.58)
11:494925	rs573724734	V>A	W:418	(24.82, 42.33, -1.99)
11:494920		S>R	W:420	(26.82, 38.50, 1.58)
11:494917	rs377143259	V>I	W:421	(28.46, 42.33, 1.77)
11:494913	rs372965525	R>Q	W:422	(22.97, 42.54, 3.50)
11:494914	COSM4033427	R>W	W:422	(22.97, 42.54, 3.50)
11:494907	rs527268281	P>L	W:424	(26.72, 41.98, 9.97)
11:494764	rs141385137	Y>C	W:437	(24.98, 46.67, -17.87)
11:494761		W>L	W:438	(25.77, 47.71, -12.12)
11:494756		E>K	W:440	(19.25, 51.90, -13.48)
11:494753		E>K	W:441	(16.55, 48.49, -9.65)
11:494749		M>T	W:442	(21.79, 46.70, -8.38)
11:494743		D>G	W:444	(19.60, 52.50, -6.50)
11:494740		R>Q	W:445	(19.57, 46.79, -5.14)
11:494741	rs367811812	R>W	W:445	(19.57, 46.79, -5.14)
11:494731		A>V	W:448	(22.00, 51.35, -0.13)
11:494716		K>R	W:453	(28.35, 47.99, 5.78)
11:494713		P>R	W:454	(29.84, 52.78, 6.00)