Assessment of Structural Intolerance and Durability
General Structure Information 4bst RSPO1 structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form 4.3Å AUTH W.C.PENG,W.DE LAU,F.FORNERIS,J.C.M.GRANNEMAN,M.HUCH,AUTH 2 H.CLEVERS,P.GROSTITL STRUCTURE OF STEM CELL GROWTH FACTOR R-SPONDIN 1 IN COMPLEXTITL 2 WITH THE ECTODOMAIN OF ITS RECEPTOR LGR5.REF CELL REP. V. 3 1885 2013REFN ISSN 2211-1247PMID 23809763DOI 10.1016/J.CELREP.2013.06.009 Variant […]
General Structure Information 3pp2 ARHGAP27 crystal structure of the pleckstrin homology domain of arhgap27 1.42Å AUTH L.SHEN,W.TEMPEL,Y.TONG,L.NEDYALKOVA,Y.LI,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OFTITL 2 ARHGAP27REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3she MAPKAPK3 novel atp-competitive mk2 inhibitors with potent biochemical and cell- based activity throughout the series 2.25Å AUTH A.OUBRIE,A.KAPTEIN,E.DE ZWART,N.HOOGENBOOM,R.GOORDEN,AUTH 2 B.VAN DE KAR,M.VAN HOEK,V.DE KIMPE,R.VAN DER HEIJDEN,AUTH 3 J.BORSBOOM,B.KAZEMIER,J.DE ROOS,M.SCHEFFERS,J.LOMMERSE,AUTH 4 C.SCHULTZ-FADEMRECHT,T.BARFTITL NOVEL ATP COMPETITIVE MK2 INHIBITORS WITH POTENT BIOCHEMICALTITL 2 AND CELL-BASED ACTIVITY THROUGHOUT THE SERIES.REF BIOORG.MED.CHEM.LETT. V. 22 613 […]
General Structure Information 4kit PRPF8 crystal structure of human brr2 in complex with the prp8 jab1/mpn domain 3.6Å AUTH S.MOZAFFARI-JOVIN,T.WANDERSLEBEN,K.F.SANTOS,C.L.WILL,AUTH 2 R.LUHRMANN,M.C.WAHLTITL INHIBITION OF RNA HELICASE BRR2 BY THE C-TERMINAL TAIL OFTITL 2 THE SPLICEOSOMAL PROTEIN PRP8.REF SCIENCE V. 341 80 2013REFN ISSN 0036-8075PMID 23704370DOI 10.1126/SCIENCE.1237515 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d8b FIGNL1 crystal structure of human fidgetin-like protein 1 in complex with adp 2.0Å AUTH T.KARLBERG,M.WISNIEWSKA,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,AUTH 5 M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,M.WELIN,AUTH 7 M.WIKSTROM,H.SCHULERTITL HUMAN FIDGETIN-LIKE PROTEIN 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4jon CEP170 crystal structure of a centrosomal protein 170kda, transcript variant beta (cep170) from homo sapiens at 2.15 a resolution (psi community target, sundstrom) 2.15Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A CENTROSOMAL PROTEIN 170KDA,TITL 2 TRANSCRIPT VARIANT BETA (CEP170) FROM HOMO SAPIENS AT 2.15 ATITL 3 RESOLUTION […]
General Structure Information 3kgr LAIR1 crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1) 1.8Å AUTH T.H.C.BRONDIJK,T.DE RUITER,J.BALLERING,H.WIENK,R.J.LEBBINK,AUTH 2 H.VAN INGEN,R.BOELENS,R.W.FARNDALE,L.MEYAARD,E.G.HUIZINGATITL CRYSTAL STRUCTURE AND COLLAGEN-BINDING SITE OF IMMUNETITL 2 INHIBITORY RECEPTOR LAIR-1: UNEXPECTED IMPLICATIONS FORTITL 3 COLLAGEN BINDING BY PLATELET RECEPTOR GPVIREF BLOOD V. 115 1364 2010REFN ISSN 0006-4971PMID 20007810DOI 10.1182/BLOOD-2009-10-246322 Variant Set Distributions Ripley’s […]
General Structure Information 2kr0 ADRM1 a proteasome protein -1.0Å AUTH X.CHEN,B.H.LEE,D.FINLEY,K.J.WALTERSTITL STRUCTURE OF PROTEASOME UBIQUITIN RECEPTOR HRPN13 AND ITSTITL 2 ACTIVATION BY THE SCAFFOLDING PROTEIN HRPN2.REF MOL.CELL V. 38 404 2010REFN ISSN 1097-2765PMID 20471946DOI 10.1016/J.MOLCEL.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 3kb5 TRIM72 pry-spry domain of human trim72 1.5Å AUTH E.Y.PARK,O.-B.KWON,B.-C.JEONG,J.-S.YI,C.S.LEE,AUTH 2 Y.-G.KO,H.K.SONGTITL CRYSTAL STRUCTURE OF PRY-SPRY DOMAIN OF HUMANTITL 2 TRIM72REF PROTEINS 2009REFN ESSN 1097-0134PMID 19967786DOI 10.1002/PROT.22647 Variant Set Distributions Mapped Variants
General Structure Information 3a6n HIST3H3 the nucleosome containing a testis-specific histone variant, human h3t 2.7Å AUTH H.TACHIWANA,W.KAGAWA,A.OSAKABE,K.KAWAGUCHI,T.SHIGA,AUTH 2 Y.HAYASHI-TAKANAKA,H.KIMURA,H.KURUMIZAKATITL STRUCTURAL BASIS OF INSTABILITY OF THE NUCLEOSOME CONTAININGTITL 2 A TESTIS-SPECIFIC HISTONE VARIANT, HUMAN H3TREF PROC.NATL.ACAD.SCI.USA V. 107 10454 2010REFN ISSN 0027-8424PMID 20498094DOI 10.1073/PNAS.1003064107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]