Assessment of Structural Intolerance and Durability
General Structure Information 4hsa IL17A structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 1de4 HFE hemochromatosis protein hfe complexed with transferrin receptor 2.8Å AUTH M.J.BENNETT,J.A.LEBRON,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF THE HEREDITARY HAEMOCHROMATOSIS PROTEINTITL 2 HFE COMPLEXED WITH TRANSFERRIN RECEPTOR.REF NATURE V. 403 46 2000REFN ISSN 0028-0836PMID 10638746DOI 10.1038/47417 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h8x ALKBH2 structure determination of dna methylation lesions n1-mea and n3-mec in duplex dna using a cross-linked host-guest system 1.95Å AUTH L.LU,C.YI,X.JIAN,G.ZHENG,C.HETITL STRUCTURE DETERMINATION OF DNA METHYLATION LESIONS N1-MEATITL 2 AND N3-MEC IN DUPLEX DNA USING A CROSS-LINKED PROTEIN-DNATITL 3 SYSTEM.REF NUCLEIC ACIDS RES. V. 38 4415 2010REFN ISSN 0305-1048PMID 20223766DOI 10.1093/NAR/GKQ129 […]
General Structure Information 3v5q NTRK3 discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models 2.2Å AUTH P.ALBAUGH,Y.FAN,Y.MI,F.SUN,F ADRIAN,N.LI,Y.YIA,Y.SARKISOVA,AUTH 2 A.KREUSCH,T.HOOD,M.LU,G.LIU,S.HUANG,Z.LIU,J.LOREN,AUTH 3 T.TUNTLAND,D.S.KARANEWSKY,H.M.SEIDEL,V.MOLTENITITL DISCOVERY OF GNF-5837, A SELECTIVE TRK INHIBITOR WITHTITL 2 EFFICACY IN RODENT CANCER TUMOR MODELSREF ACS MED.CHEM.LETT. 2012REFN ISSN 1948-5875DOI 10.1021/ML200261D Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4hon KDM4D crystal structure of human jmjd2d/kdm4d in complex with an h3k9me3 peptide and 2-oxoglutarate 1.8Å AUTH S.KRISHNAN,R.C.TRIEVELTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF JMJD2D REVEALSTITL 2 MOLECULAR BASIS FOR SITE-SPECIFIC DEMETHYLATION AMONG JMJD2TITL 3 DEMETHYLASES.REF STRUCTURE V. 21 98 2013REFN ISSN 0969-2126PMID 23219879DOI 10.1016/J.STR.2012.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2y73 AOC3 the native structures of soluble human primary amine oxidase aoc3 2.6Å AUTH H.ELOVAARA,H.KIDRON,V.PARKASH,Y.NYMALM,E.BLIGT,P.OLLIKKA,AUTH 2 D.J.SMITH,M.PIHLAVISTO,M.SALMI,S.JALKANEN,T.A.SALMINENTITL IDENTIFICATION OF TWO IMIDAZOLE BINDING SITES AND KEYTITL 2 RESIDUES FOR SUBSTRATE SPECIFICITY IN HUMAN PRIMARY AMINETITL 3 OXIDASE AOC3.REF BIOCHEMISTRY V. 50 5507 2011REFN ISSN 0006-2960PMID 21585208DOI 10.1021/BI200117Z Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3eap ARHGAP11A crystal structure of the rhogap domain of arhgap11a 2.3Å AUTH Y.SHEN,L.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3t5x PCID2 pcid2:dss1 structure 2.12Å AUTH A.M.ELLISDON,L.DIMITROVA,E.HURT,M.STEWARTTITL STRUCTURAL BASIS FOR THE ASSEMBLY AND NUCLEIC ACID BINDINGTITL 2 OF THE TREX-2 TRANSCRIPTION-EXPORT COMPLEX.REF NAT.STRUCT.MOL.BIOL. V. 19 328 2012REFN ISSN 1545-9993PMID 22343721DOI 10.1038/NSMB.2235 Variant Set Distributions Mapped Variants
General Structure Information 3bq7 DGKD sam domain of diacylglycerol kinase delta1 (e35g) 2.9Å AUTH B.T.HARADA,M.J.KNIGHT,S.IMAI,F.QIAO,R.RAMACHANDER,AUTH 2 M.R.SAWAYA,M.GINGERY,F.SAKANE,J.U.BOWIETITL REGULATION OF ENZYME LOCALIZATION BYTITL 2 POLYMERIZATION: POLYMER FORMATION BY THE SAMTITL 3 DOMAIN OF DIACYLGLYCEROL KINASE DELTA1REF STRUCTURE V. 16 380 2008REFN ISSN 0969-2126PMID 18334213DOI 10.1016/J.STR.2007.12.017 Variant Set Distributions Mapped Variants
General Structure Information 1r79 DGKD solution structure of the c1 domain of the human diacylglycerol kinase delta -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C1 DOMAIN OF THE HUMANTITL 2 DIACYLGLYCEROL KINASE DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants