Assessment of Structural Intolerance and Durability
General Structure Information 2y4i KSR2 ksr2-mek1 heterodimer 3.46Å AUTH D.F.BRENNAN,A.C.DAR,N.T.HERTZ,W.CHAO,A.L.BURLINGAME,AUTH 2 K.M.SHOKAT,D.BARFORDTITL A RAF-INDUCED ALLOSTERIC TRANSITION OF KSR STIMULATES KSRTITL 2 AND RAF PHOSPHORYLATION OF MEKREF NATURE V. 472 366 2011REFN ISSN 0028-0836PMID 21441910DOI 10.1038/NATURE09860 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dou ADIPOQ crystal structure of a single-chain trimer of human adiponectin globular domain 2.0Å AUTH X.MIN,B.LEMON,J.TANG,Q.LIU,R.ZHANG,N.WALKER,Y.LI,Z.WANGTITL CRYSTAL STRUCTURE OF A SINGLE-CHAIN TRIMER OF HUMANTITL 2 ADIPONECTIN GLOBULAR DOMAIN.REF FEBS LETT. V. 586 912 2012REFN ISSN 0014-5793PMID 22449980DOI 10.1016/J.FEBSLET.2012.02.024 Variant Set Distributions Mapped Variants
General Structure Information 3ldb JMJD6 structure of jmjd6 complexd with alpha-ketoglutarate and fab fragment. 2.7Å AUTH X.HONG,J.ZANG,J.WHITE,C.WANG,C.H.PAN,R.ZHAO,R.C.MURPHY,AUTH 2 S.DAI,P.HENSON,J.W.KAPPLER,J.HAGMAN,G.ZHANGTITL INTERACTION OF JMJD6 WITH SINGLE-STRANDED RNA.REF PROC.NATL.ACAD.SCI.USA V. 107 14568 2010REFN ISSN 0027-8424PMID 20679243DOI 10.1073/PNAS.1008832107 Variant Set Distributions Mapped Variants
General Structure Information 2edv FRMPD1 solution structure of the pdz domain from human ferm and pdz domain containing 1 -1.0Å AUTH K.SEIMIYA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 FERM AND PDZ DOMAIN CONTAINING 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2edr OBSCN solution structure of the ig-like domain (3361-3449) of human obscurin -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IG-LIKE DOMAINTITL 2 (3361-3449) OF HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mkp DUSP6 crystal structure of pyst1 (mkp3) 2.35Å AUTH A.E.STEWART,S.DOWD,S.M.KEYSE,N.Q.MCDONALDTITL CRYSTAL STRUCTURE OF THE MAPK PHOSPHATASE PYST1TITL 2 CATALYTIC DOMAIN AND IMPLICATIONS FOR REGULATEDTITL 3 ACTIVATION.REF NAT.STRUCT.BIOL. V. 6 174 1999REFN ISSN 1072-8368PMID 10048930DOI 10.1038/5861 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pmi MUM1 pwwp domain of human mutated melanoma-associated antigen 1 2.82Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Mapped Variants
General Structure Information 2v9k PUS10 crystal structure of human pus10, a novel pseudouridine synthase. 2.0Å AUTH C.J.MCCLEVERTY,M.HORNSBY,G.SPRAGGON,A.KREUSCHTITL CRYSTAL STRUCTURE OF HUMAN PUS10, A NOVEL PSEUDOURIDINETITL 2 SYNTHASE.REF J.MOL.BIOL. V. 373 1243 2007REFN ISSN 0022-2836PMID 17900615DOI 10.1016/J.JMB.2007.08.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ucr TIGIT crystal structure of the immunoreceptor tigit igv domain 2.63Å AUTH K.F.STENGEL,K.HARDEN-BOWLES,X.YU,L.ROUGE,J.YIN,AUTH 2 L.COMPS-AGRAR,C.WIESMANN,J.F.BAZAN,D.L.EATON,J.L.GROGANTITL STRUCTURE OF TIGIT IMMUNORECEPTOR BOUND TO POLIOVIRUSTITL 2 RECEPTOR REVEALS A CELL-CELL ADHESION AND SIGNALINGTITL 3 MECHANISM THAT REQUIRES CIS-TRANS RECEPTOR CLUSTERING.REF PROC.NATL.ACAD.SCI.USA V. 109 5399 2012REFN ISSN 0027-8424PMID 22421438DOI 10.1073/PNAS.1120606109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3e9l PRPF8 crystal structure of human prp8, residues 1755-2016 1.95Å AUTH V.PENA,A.ROZOV,P.FABRIZIO,R.LUHRMANN,M.C.WAHLTITL STRUCTURE AND FUNCTION OF AN RNASE H DOMAIN AT THE HEART OFTITL 2 THE SPLICEOSOME.REF EMBO J. V. 27 2929 2008REFN ISSN 0261-4189PMID 18843295DOI 10.1038/EMBOJ.2008.209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants