Assessment of Structural Intolerance and Durability
General Structure Information 2a7o SETD2 solution structure of the hset2/hypb sri domain -1.0Å AUTH M.LI,H.P.PHATNANI,Z.GUAN,H.SAGE,A.GREENLEAF,P.ZHOUTITL SOLUTION STRUCTURE OF THE SET2 RPB1 INTERACTINGTITL 2 DOMAIN OF HUMAN SET2 AND ITS INTERACTION WITH THETITL 3 HYPERPHOSPHORYLATED C-TERMINAL DOMAIN OF RPB1REF PROC.NATL.ACAD.SCI.USA V. 102 17636 2005REFN ISSN 0027-8424PMID 16314571DOI 10.1073/PNAS.0506350102 Variant Set Distributions Mapped Variants
General Structure Information 2bmj AGAP2 gtpase like domain of centaurin gamma 1 (human) 2.1Å AUTH M.SOUNDARARAJAN,X.YANG,J.M.ELKINS,F.SOBOTT,D.A.DOYLETITL THE CENTAURIN GAMMA-1 GTPASE-LIKE DOMAIN FUNCTIONS AS ANTITL 2 NTPASE.REF BIOCHEM.J. V. 401 679 2007REFN ISSN 0264-6021PMID 17037982DOI 10.1042/BJ20060555 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kuq DLC1 crystal structure of the dlc1 rhogap domain 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,F.MACKENZIE,L.SHEN,AUTH 2 N.ZHONG,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE DLC1 RHOGAP DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d9q CSF3R crystal structure of the human gcsf-receptor signaling complex 2.8Å AUTH T.TAMADA,E.HONJO,Y.MAEDA,T.OKAMOTO,M.ISHIBASHI,M.TOKUNAGA,AUTH 2 R.KUROKITITL HOMODIMERIC CROSS-OVER STRUCTURE OF THE HUMAN GRANULOCYTETITL 2 COLONY-STIMULATING FACTOR (GCSF) RECEPTOR SIGNALING COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 103 3135 2006REFN ISSN 0027-8424PMID 16492764DOI 10.1073/PNAS.0511264103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vvw MAP1LC3C ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4clt ADCY10 crystal structure of human soluble adenylyl cyclase with adenosine-3,5-cyclic-monophosphate and pyrophosphate 1.95Å AUTH S.KLEINBOELTING,A.DIAZ,S.MONIOT,J.VAN DEN HEUVEL,M.WEYAND,AUTH 2 L.R.LEVIN,J.BUCK,C.STEEGBORNTITL CRYSTAL STRUCTURES OF HUMAN SOLUBLE ADENYLYL CYCLASE REVEALTITL 2 MECHANISMS OF CATALYSIS AND OF ITS ACTIVATION THROUGHTITL 3 BICARBONATE.REF PROC.NATL.ACAD.SCI.USA V. 111 3727 2014REFN ISSN 0027-8424PMID 24567411DOI 10.1073/PNAS.132277811 Variant Set Distributions Ripley’s […]
General Structure Information 2k2d RCHY1 solution nmr structure of c-terminal domain of human pirh2. northeast structural genomics consortium (nesg) target ht2c -1.0Å AUTH Y.SHENG,R.C.LAISTER,A.LEMAK,B.WU,E.TAI,S.DUAN,AUTH 2 J.LUKIN,M.SUNNERHAGEN,S.SRISAILAM,M.KARRA,AUTH 3 S.BENCHIMOL,C.H.ARROWSMITHTITL MOLECULAR BASIS OF PIRH2-MEDIATED P53TITL 2 UBIQUITYLATION.REF NAT.STRUCT.MOL.BIOL. V. 15 1334 2008REFN ISSN 1545-9993PMID 19043414DOI 10.1038/NSMB.1521 Variant Set Distributions Mapped Variants
General Structure Information 2y33 EGLN1 s-nitrosylated phd2 (gsno soaked) in complex with zn(ii) and un9 2.0Å AUTH R.CHOWDHURY,E.FLASHMAN,J.MECINOVIC,H.B.KRAMER,B.M.KESSLER,AUTH 2 Y.M.FRAPART,J.-L.BOUCHER,I.J.CLIFTON,M.A.MCDONOUGH,AUTH 3 C.J.SCHOFIELDTITL STUDIES ON THE REACTION OF NITRIC OXIDE WITH THETITL 2 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE DOMAIN 2TITL 3 (EGLN1)REF J.MOL.BIOL. V. 410 268 2011REFN ISSN 0022-2836PMID 21601578DOI 10.1016/J.JMB.2011.04.075 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3v6a API5 helical repeat structure of apoptosis inhibitor 5 reveals protein- protein interaction modules 2.6Å AUTH B.G.HAN,K.H.KIM,S.J.LEE,K.C.JEONG,J.W.CHO,K.H.NOH,T.W.KIM,AUTH 2 S.J.KIM,H.J.YOON,S.W.SUH,S.H.LEE,B.I.LEETITL HELICAL REPEAT STRUCTURE OF APOPTOSIS INHIBITOR 5 REVEALSTITL 2 PROTEIN-PROTEIN INTERACTION MODULES.REF J.BIOL.CHEM. V. 287 10727 2012REFN ISSN 0021-9258PMID 22334682DOI 10.1074/JBC.M111.317594 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3mvb MTERF crystal structure of a triple rfy mutant of human mterf1 bound to the termination sequence 2.79Å AUTH E.YAKUBOVSKAYA,E.MEJIA,J.BYRNES,E.HAMBARDJIEVA,AUTH 2 M.GARCIA-DIAZTITL HELIX UNWINDING AND BASE FLIPPING ENABLE HUMAN MTERF1 TOTITL 2 TERMINATE MITOCHONDRIAL TRANSCRIPTION.REF CELL(CAMBRIDGE,MASS.) V. 141 982 2010REFN ISSN 0092-8674PMID 20550934DOI 10.1016/J.CELL.2010.05.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]