Assessment of Structural Intolerance and Durability
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3twr TNKS2 crystal structure of arc4 from human tankyrase 2 in complex with peptide from human 3bp2 1.55Å AUTH S.GUETTLER,J.LAROSE,E.PETSALAKI,G.GISH,A.SCOTTER,T.PAWSON,AUTH 2 R.ROTTAPEL,F.SICHERITITL STRUCTURAL BASIS AND SEQUENCE RULES FOR SUBSTRATETITL 2 RECOGNITION BY TANKYRASE EXPLAIN THE BASIS FOR CHERUBISMTITL 3 DISEASE.REF CELL(CAMBRIDGE,MASS.) V. 147 1340 2011REFN ISSN 0092-8674PMID 22153077DOI 10.1016/J.CELL.2011.10.046 Variant Set Distributions […]
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2crf RANBP3 solution structure of the ran_bp1 domain of ran-binding protein-3 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RAN_BP1 DOMAIN OFTITL 2 RAN-BINDING PROTEIN-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gao SAR1A crystal structure of human sar1a in complex with gdp 2.0Å AUTH J.WANG,S.DIMOV,W.TEMPEL,D.YANIW,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN SAR1A IN COMPLEX WITHTITL 2 GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yz4 DUSP15 crystal structure of dusp15 2.4Å AUTH T.S.YOON,D.G.JEONG,J.H.KIM,Y.H.CHO,J.H.SON,J.W.LEE,AUTH 2 S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 VHY, A DUAL-SPECIFICITY PROTEIN PHOSPHATASEREF PROTEINS V. 61 694 2005REFN ISSN 0887-3585PMID 16170801DOI 10.1002/PROT.20642 Variant Set Distributions Mapped Variants
General Structure Information 4m0a POLM human dna polymerase mu post-catalytic complex 1.85Å AUTH A.F.MOON,J.M.PRYOR,D.A.RAMSDEN,T.A.KUNKEL,K.BEBENEK,AUTH 2 L.C.PEDERSENTITL SUSTAINED ACTIVE SITE RIGIDITY DURING SYNTHESIS BY HUMAN DNATITL 2 POLYMERASE MU.REF NAT.STRUCT.MOL.BIOL. V. 21 253 2014REFN ISSN 1545-9993PMID 24487959DOI 10.1038/NSMB.2766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q3f RRAGD x-ray crystal structure of putative human ras-related gtp binding d in complex with gmppnp 2.1Å AUTH A.M.MULICHAK,W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,AUTH 2 R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 3 J.WEIGELT,L.J.KEEFE,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-RELATED GTP-BINDINGTITL 2 D.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cgy RMI1 crystal structure of the human topoisomerase iii alpha-rmi1 complex 2.85Å AUTH N.BOCQUET,A.H.BIZARD,W.ABDULRAHMAN,N.B.LARSEN,M.FATY,AUTH 2 S.CAVADINI,R.D.BUNKER,S.C.KOWALCZYKOWSKI,P.CEJKA,AUTH 3 I.D.HICKSON,N.H.THOMATITL STRUCTURAL AND MECHANISTIC INSIGHT INTO HOLLIDAY-JUNCTIONTITL 2 DISSOLUTION BY TOPOISOMERASE IIIALPHA AND RMI1REF NAT.STRUCT.MOL.BIOL. V. 21 261 2014REFN ISSN 1545-9993PMID 24509834DOI 10.1038/NSMB.2775 Variant Set Distributions Mapped Variants
General Structure Information 1k9i CD209 complex of dc-sign and glcnac2man3 2.5Å AUTH H.FEINBERG,D.A.MITCHELL,K.DRICKAMER,W.I.WEISTITL STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OFTITL 2 OLIGOSACCHARIDES BY DC-SIGN AND DC-SIGNR.REF SCIENCE V. 294 2163 2001REFN ISSN 0036-8075PMID 11739956DOI 10.1126/SCIENCE.1066371 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants