Assessment of Structural Intolerance and Durability
General Structure Information 2r55 STARD5 human star-related lipid transfer protein 5 2.5Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 4hfg RPRD1B cid of human rprd1b 2.0Å AUTH Z.NI,C.XU,W.TEMPEL,M.EL BAKKOURI,P.LOPPNAU,X.GUO,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,J.F.GREENBLATTTITL CID OF HUMAN RPRD1BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fla RPRD1B crystal structure of human rprd1b, carboxy-terminal domain 2.2Å AUTH Z.NI,C.XU,X.GUO,G.O.HUNTER,O.V.KUZNETSOVA,W.TEMPEL,E.MARCON,AUTH 2 G.ZHONG,H.GUO,W.H.KUO,J.LI,P.YOUNG,J.B.OLSEN,C.WAN,AUTH 3 P.LOPPNAU,M.EL BAKKOURI,G.A.SENISTERRA,H.HE,H.HUANG,AUTH 4 S.S.SIDHU,A.EMILI,S.MURPHY,A.L.MOSLEY,C.H.ARROWSMITH,J.MIN,AUTH 5 J.F.GREENBLATTTITL RPRD1A AND RPRD1B ARE HUMAN RNA POLYMERASE II C-TERMINALTITL 2 DOMAIN SCAFFOLDS FOR SER5 DEPHOSPHORYLATION.REF NAT.STRUCT.MOL.BIOL. V. 21 686 2014REFN ISSN 1545-9993PMID 24997600DOI 10.1038/NSMB.2853 Variant Set Distributions Mapped Variants
General Structure Information 1eaz PLEKHA1 crystal structure of the phosphoinositol (3,4)-bisphosphate binding ph domain of tapp1 from human. 1.4Å AUTH C.C.THOMAS,S.DOWLER,M.DEAK,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF THE PHOSPHATIDYLINOSITOLTITL 2 3,4-BISPHOSPHATE-BINDING PLECKSTRIN HOMOLOGY (PH)TITL 3 DOMAIN OF TANDEM PH-DOMAIN-CONTAINING PROTEIN 1TITL 4 (TAPP1): MOLECULAR BASIS OF LIPID SPECIFICITYREF BIOCHEM.J. V. 358 287 2001REFN ISSN 0264-6021PMID […]
General Structure Information 2mgx SRA1 nmr structure of sra1p c-terminal domain -1.0Å AUTH S.M.BILINOVICH,C.M.DAVIS,D.L.MORRIS,L.A.RAY,J.W.PROKOP,AUTH 2 G.J.BUCHAN,T.C.LEEPERTITL THE C-TERMINAL DOMAIN OF SRA1P HAS A FOLD MORE SIMILAR TOTITL 2 PRP18 THAN TO AN RRM AND DOES NOT DIRECTLY BIND TO THE SRA1TITL 3 RNA STR7 REGION.REF J.MOL.BIOL. V. 426 1753 2014REFN ISSN 0022-2836PMID 24486611DOI 10.1016/J.JMB.2014.01.007 Variant […]
General Structure Information 3zi1 GLOD4 crystal structure of human glyoxalase domain-containing protein 4 (glod4) 1.9Å AUTH A.OBERHOLZE,W.KIYANI,L.SHRESTHA,M.VOLLMAR,T.KROJER,AUTH 2 D.S.FROESE,E.WILLIAMS,F.VON DELFT,N.BURGESS-BROWN,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN GLYOXALASE DOMAIN- CONTAININGTITL 2 PROTEIN 4 (GLOD4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4e74 PLXNA4 crystal structure of the rho gtpase binding domain of plexin a4a 1.58Å AUTH X.GUAN,H.WANG,W.TEMPEL,A.DONG,Y.TONG,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 A4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ceg BIRC6 crystal structure of the ubc domain of baculoviral iap repeat- containing protein 6 2.01Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3o65 ATXN3L crystal structure of a josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity 2.7Å AUTH S.D.WEEKS,K.C.GRASTY,L.HERNANDEZ-CUEBAS,P.J.LOLLTITL CRYSTAL STRUCTURE OF A JOSEPHIN-UBIQUITIN COMPLEX:TITL 2 EVOLUTIONARY RESTRAINTS ON ATAXIN-3 DEUBIQUITINATINGTITL 3 ACTIVITY.REF J.BIOL.CHEM. V. 286 4555 2011REFN ISSN 0021-9258PMID 21118805DOI 10.1074/JBC.M110.177360 Variant Set Distributions Mapped Variants
General Structure Information 3rau PTPN23 crystal structure of the hd-ptp bro1 domain 1.95Å AUTH P.SETTE,R.MU,V.DUSSUPT,J.JIANG,G.SNYDER,P.SMITH,T.S.XIAO,AUTH 2 F.BOUAMRTITL THE PHE105 LOOP OF ALIX BRO1 DOMAIN PLAYS A KEY ROLE INTITL 2 HIV-1 RELEASE.REF STRUCTURE V. 19 1485 2011REFN ISSN 0969-2126PMID 21889351DOI 10.1016/J.STR.2011.07.016 Variant Set Distributions Mapped Variants