4CGY.B | RMI1 – ASTRID

4CGY.B | RMI1

General Structure Information

PDB ID	4cgy
HGNC Gene Label(s)	RMI1
Structure Name	crystal structure of the human topoisomerase iii alpha-rmi1 complex
Resolution	2.85Å
Reference	AUTH N.BOCQUET,A.H.BIZARD,W.ABDULRAHMAN,N.B.LARSEN,M.FATY,AUTH 2 S.CAVADINI,R.D.BUNKER,S.C.KOWALCZYKOWSKI,P.CEJKA,AUTH 3 I.D.HICKSON,N.H.THOMATITL STRUCTURAL AND MECHANISTIC INSIGHT INTO HOLLIDAY-JUNCTIONTITL 2 DISSOLUTION BY TOPOISOMERASE IIIALPHA AND RMI1REF NAT.STRUCT.MOL.BIOL. V. 21 261 2014REFN ISSN 1545-9993PMID 24509834DOI 10.1038/NSMB.2775

Variant Set Distributions

ExAC Variants

Number Of Residues	205
Number Of SNVs	49
Number Of Permutations	41433
Optimal Distance Threshold	6.0
K Statistic	0.029
p-value	0.979

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:86615911		T>A	B:4	(-63.75, -33.22, -27.20)
9:86615914		S>G	B:5	(-66.64, -34.60, -24.17)
9:86615920		A>S	B:7	(-63.16, -30.57, -22.69)
9:86615929	rs546875996	A>T	B:10	(-63.89, -28.57, -18.19)
9:86615935		T>S	B:12	(-68.12, -25.33, -18.58)
9:86615948		A>V	B:16	(-67.96, -21.24, -13.70)
9:86615959		V>F	B:20	(-60.23, -20.18, -16.25)
9:86615968		P>S	B:23	(-56.31, -23.29, -24.93)
9:86615971		P>A	B:24	(-58.48, -25.96, -27.33)
9:86615972	rs373651916	P>L	B:24	(-58.48, -25.96, -27.33)
9:86615975		M>T	B:25	(-55.43, -28.02, -28.54)
9:86615976		M>I	B:25	(-55.43, -28.02, -28.54)
9:86616031		S>C	B:44	(-64.59, -38.16, -12.31)
9:86616112	rs149519006	D>N	B:71	(-56.87, -5.52, -27.67)
9:86616115		G>S	B:72	(-54.72, -1.66, -25.82)
9:86616139		E>K	B:80	(-63.29, 2.15, -15.78)
9:86616165		Q>H	B:88	(-49.13, -15.13, -14.37)
9:86616173		S>F	B:91	(-43.18, -9.86, -10.19)
9:86616175		L>V	B:92	(-44.62, -8.96, -5.97)
9:86616177		L>F	B:92	(-44.62, -8.96, -5.97)
9:86616182	rs377508790	D>V	B:94	(-43.29, -2.95, -0.76)
9:86616217	rs189141817	L>M	B:106	(-34.76, -11.11, 3.22)
9:86616223		G>R	B:108	(-30.95, -11.35, 8.65)
9:86616245		L>P	B:115	(-31.06, 2.66, 13.76)
9:86616247	rs145880625	V>L	B:116	(-28.07, 3.67, 17.94)
9:86616251		T>R	B:117	(-29.27, 7.69, 18.47)
9:86616299		R>Q	B:133	(-48.88, -3.90, 1.92)
9:86616303		M>I	B:134	(-48.22, 0.04, -2.35)
9:86616329	rs370446452	I>T	B:143	(-49.89, -11.89, -24.75)
9:86616331	rs181806949	V>I	B:144	(-50.29, -8.11, -22.08)
9:86616344		G>E	B:148	(-50.61, -3.85, -9.94)
9:86616352		Y>N	B:151	(-56.45, 2.87, -4.35)
9:86616356		Q>R	B:152	(-58.16, 0.04, -1.22)
9:86616358		P>S	B:153	(-55.75, -2.44, 1.93)
9:86616365	rs186831638	P>L	B:155	(-54.98, -8.68, 2.96)
9:86616367	rs201209251	I>V	B:156	(-55.19, -12.00, -0.16)
9:86616376		S>G	B:159	(-44.09, -10.48, -0.66)
9:86616410		Y>C	B:170	(-63.22, -9.59, -8.97)
9:86616420		I>M	B:173	(-60.52, -2.27, -12.15)
9:86616421	rs368843569	S>P	B:174	(-59.63, 2.07, -12.32)
9:86616422	rs553690871	S>C	B:174	(-59.63, 2.07, -12.32)
9:86616427		R>C	B:176	(-54.89, 6.71, -14.49)
9:86616428		R>H	B:176	(-54.89, 6.71, -14.49)
9:86616434		G>V	B:178	(-50.53, 0.45, -16.76)
9:86616443	rs200956667	L>S	B:181	(-56.22, 1.45, -9.38)
9:86616450		K>N	B:183	(-60.41, -1.53, -4.65)
9:86616451	rs578261023	P>S	B:184	(-59.98, -5.61, -1.80)
9:86616459	rs200445200 COSM753999	N>K	B:186	(-61.29, -5.93, -7.45)
9:86616460		V>M	B:187	(-58.32, -9.48, -5.60)
9:86616481		V>L	B:194	(-43.97, -20.71, -12.79)
9:86616487	rs557538407	A>S	B:196	(-39.18, -20.45, -14.57)
9:86616488	rs575616928	A>V	B:196	(-39.18, -20.45, -14.57)
9:86616524	rs374998082	A>V	B:208	(-31.08, -6.66, -5.84)
9:86616533		I>T	B:211	(-29.95, -2.25, -4.48)
9:86616542		P>R	B:214	(-24.18, -7.58, -9.46)